Retroperitoneal xanthogranuloma and xanthosarcoma (malignant fibrous xanthoma)

Kahn, Leonard B.

doi:10.1002/1097-0142(197302)31:2<411::aid-cncr2820310219>3.0.co;2-0

Cited by 56 publications

(11 citation statements)

References 14 publications

(1 reference statement)

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“…The AFX lacks a storiform pattern but may have many of the other features of an MFH, including numerous typical and atypical mitotic figures. When such a pleomorphic tumor is small and confined to the dermis, it seems best to gse the designation AFX, but when such tumors are large, show 2262 CANCER June 1978 Vol. 41 extensive necrosis, or involve the deep subcutis we prefer to classify them as MFH.…”

Section: Differential Diagnosismentioning

confidence: 99%

Malignant fibrous histiocytoma.An Analysis of 200 Cases

Weiss

Enzinger

1978

Cancer

1,363

609

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The clinicopathologic findings in 200 cases of malignant fibrous histiocytoma (MFH) with follow-up information are presented. This tumor occurred principally as a mass on an extremity (lower extremity 49%, upper extremity 19%) or in the abdominal cavity or retroperitoneum (16%) of adults (peak incidence 61-70 years of age). It typically involved deep fascia (19%) o r skeletal muscle (59%) and only rarely was confined to the subcutis without fascia1 involvement (7%). The MFH had variable morphologic features and frequently showed transitions from areas having a highly ordered storiform pattern to less differentiated areas having a pleomorphic appearance. The rate of local recurrence of the tumor was 44%, and of metastasis, 42%. Metastasis was most frequently to the lung (82%) and lymph nodes (32%). Factors that influenced the rate of metastasis included depth, size, and inflammatory component of the tumor. Tumors that were small, superficially located, or had a prominent inflammatory component metastasized less frequently than larger, more deeply located tumors. In our experience the MFH is the most common soft tissue sarcoma of late adult life, and many tumors previously diagnosed as pleomorphic variants of liposarcoma, fibrosarcoma, or rhabdomyosarcoma are probably examples of MFH. Although the histogenesis of this neoplasm remains controversial, we feel it is best regarded as a primitive and pleomorphic sarcoma showing partial fibroblastic and histiocytic differentiation, as reflected by collagen production and occasional phagocytosis.

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Section: Differential Diagnosismentioning

confidence: 99%

Malignant fibrous histiocytoma.An Analysis of 200 Cases

Weiss

Enzinger

1978

Cancer

1,363

609

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“…Tumor was found to have invaded the uterus as well as the right hemidiaphragm. 5 At the Penrose Cancer Seminar, Stout discussed a case of a 73-year-old male with a retroperitoneal xanthogranuloma which histologically was heavily infiltrated with polys and histiocytes. This patient died soon after surgery and at autopsy no residual tumor was…”

Section: Vol 37mentioning

confidence: 99%

Inflammatory fibrous histiocytoma—An aggressive and lethal lesion

Kyriakos

Kempson

1976

Cancer

213

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During a n investigation of soft tissue fibrohistiocytic tumors, seven cases were found which we believe represent a new and specific diagnostic subgroup of the fibrous histiocytomas. All patients were adults (mean 52.6 years), only one of whom was younger than age 40. There were four females a n d three males; all were Caucasian. T h e tumors, which occurred in the retroperitoneum, anterior chest wall, anterior abdominal wall, femoral area, and oral cavity, were large, averaging 8.5 cm., a n d although appearing encapsulated, were microscopically infiltrative. T h e common histologic feature of all cases was a diffuse and a t times intense neutrophilic infiltrate unassociated with tissue necrosis, in combination with bland a n d anaplastic appearing histiocytes. T h e presence of this acute exudative reaction is a unique feature of these lesions, a n d was present not only in the original tumors, but in recurrences and metastatic foci as well. Other cell types including foam cells, lymphocytes, plasma cells, eosinophils, ReedSternberglike and ganglion-like cells were commonly present. A storiform fibrous pattern, a hallmark of the fibrous histiocytomas was seen at some time in all

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“…An MR T2-weighted image (TR = 4.3 ms/rE = 60.0 ms). A hypointense rim surrounding both "kidneys is seen ma with xanthomatous and inflammatory cells [4,5,6]. Retroperitoneal xanthogranuloma occurs sporadically or can be associated with Erdheim-Chester disease.…”

Section: Discussionmentioning

confidence: 99%