Inflammatory fibrous histiocytoma—An aggressive and lethal lesion

Kyriakos, Michael; Kempson, Richard L.

doi:10.1002/1097-0142(197603)37:3<1584::aid-cncr2820370349>3.0.co;2-5

Cited by 213 publications

(37 citation statements)

References 14 publications

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“…G-CSF-producing tumors originating in non-epithelial tis- sues are rare. Wefound several cases of G-CSF-producing MFH in the Japanese literature (8)(9)(10)(11)(12)(13)(14) and in the literature of other countries (15)(16)(17)(18)(19) from the retroperitoneum with a white blood cell count of 44,500/|il. They diagnosed it as a G-CSF-producing tumor because the serum G-CSF was 400 pg/ml (normal: <100 pg/ml) and the white blood cell count was normalized after removal of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Malignant Fibrous Histiocytoma of Soft Tissue Producing Granulocyte Colony-Stimulating Factor.

et al. 2001

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Wetreated a rare case of malignant fibrous histiocytoma (MFH) of soft tissue that produced granulocyte colonystimulating factor (G-CSF). The patient, an 80-year-old woman,was admitted because of a feeling of abdominal fullness and leg edema. An elastic, hard, tender tumor was palpated in the right thigh. Histopathological examinations of the tumor revealed atypical and prominent pleomorphic spindle-shaped cells with funicular arrangement, which were compatible with the diagnosis of MFH.Prominent leukocytosis (up to 84,300/|il), a high serum G-CSF concentration (82 pg/ml) and positive immunohistochemical staining of the tumor tissue for G-CSFindicated that G-CSF was produced by the MFH. (Internal Medicine 40: 536-540, 2001)

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Section: Discussionmentioning

confidence: 99%

Malignant Fibrous Histiocytoma of Soft Tissue Producing Granulocyte Colony-Stimulating Factor.

et al. 2001

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“…The myxoid subtype is the second most common variant, with definite metastatic potential, but a relatively indolent natural history compared with the storiform-pleomorphic variant [12] . The inflammatory MFH was first described by Kyriakos et al [13] in 1976. Unlike other types of MFHs, inflammatory MFH is more likely to develop in the retroperitoneum than in extremities [14] .…”

Section: Mfh Pathological and Clinical Featuresmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation

Karki

Xu²,

Wu³

et al. 2012

WJR

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AIM:To study computed tomography (CT) �eatures of abdominal malignant fibrous histiocytoma (MFH) in various rare locations. METHODS:We retroprospectively identi�ied cases o� �FH involving the abdominal cavity. �articular attention was paid to details regarding imaging �eatures and histological types. RESULTS:The study population consisted o� seven men and one woman, with a mean age o� 52.5 years. Seven patients had some physical symptoms, while one was incidentally detected. The sites o� origin were liver (n = 3), greater omentum (n = 1), superior mesentery (n = 1), ileum (n = 1), right psoas muscle (n = 1) and right kidney (n = 1). With the exception o� the ileum lesion, all were o� huge size. The contour o� the lesions was more or less clear. Foci o� necrosis were present in six lesions (n = 6). On plain CT scan, all lesions were hypo to iso dense. The lesion in the greater omentum was cystic. One lesion (n = 1) showed signi�icant enhancement and the cystic lesion showed mild peripheral enhancement. An abundance o� blood vessels surrounding the mass was seen in two lesions (n = 2) and both were o� the in�lammatory variety. �athological examination revealed stori�orm-pleomorphic variety (n = 4), inflammatory variety (n = 3) and myxoid variety (n = 1). Two of the patients with inflammatory MFH had a clinical presentation o� �ever and one was a�ebrile, however, blood investigations in all three showed leukocytosis.CONCLUSION: �rimary �FHs o� the abdominal viscera and gastrointestinal tract are generally huge so�t tissue masses containing areas o� low attenuation and mild to moderate contrast enhancement.

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“…Equivalent amounts of total RNA per amount of gel were assessed by monitoring 28S and 18S rRNA. (Serke et al, 1986), neutrophilia, and myeloid hyperplasia (Kyriakos & Kempson, 1976;Roques et al, 1979). Previous studies have demonstrated that bioactive factors which could explain these clinical features were produced by the MFH cells in vitro.…”

Section: Cell Linesmentioning

confidence: 99%

Neutrophil chemotactic factors produced by malignant fibrous histiocytoma cell lines

Yoshida

Matsuzaki²,

Hata³

et al. 1993

Br J Cancer

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(Tani et al., 1990).The infiltration of monocytes-macrophage into the tumour is a typical feature of MFH (Weiss & Enzinger, 1978). Among the several active cytokines secreted by infiltrating macrophages, IL-1 and tumour necrosis factor (TNF) are likely to be an important in inflammation and tissue damage (Oppenheim et al., 1986;Le & Vilcek, 1987). Stimulation by exogenious IL-1 and TNF can induce promotion and modification of production of GM-CSF and IL-8/NAP-1 in various cells (Munker et al., 1986;Zucali et al., 1986;Matsushima et al., 1988;Strieter et al., 1989;Brennan et al., 1990;Seitz et al., 1991;Zoja et al., 1991; Meir et al., 1992).In this paper, we examined neutrophil chemotactic factor production by MFH cell lines and their expression of GM-CSF and IL-8/NAP-1 mRNA with or without IL-1p stimulation. Materials and methods Cell linesThe three human MFH cell lines (MF-1, MF-3, MF-4) were established by H. Okabe (Okabe et al., 1987;Takeya et al., 1991) and MF-SH was the generous gift of Dr K. Shirasuna (Shirasuna et al., 1985). The Human thyroid carcinoma cell line, KHM-5M (Yoshida et al., 1992) was used as a positive control for GM-CSF and IL-8/NAP-1 expression, and a human multiple myeloma cell line, KHM-7 established in our laboratory was used as the negative control.Culture conditions Cells were grown to confluence in 25 mm2 flasks at 37'C in humidified 95% air/5% C02, using RPMI 1640 medium containing 10% fetal bovine serum (FBS) as the culture medium. On the day of use cells were washed with RPMI1640 medium and incubated with IL-1p in RPMI1640 medium containing 0.1% bovine serum albumin (BSA) for the specified times and doses. Cell-free supernatants were harvested, dialysed with Dulbecco's calcium-and magnesium-free phosphate-buffered saline (CMF-PBS) (pH. 7.4), and then tested for neutrophil chemotactic activity. Total cellular RNA was extracted from 1-2 x 107 cells and analysed as described below. Reagent preparationHuman IL-1p, with a specific activity of 2 x 107 UMmg', was a generous gift of Otsuka Parmaceutical Co. Ltd. (Tokyo, Japan). Dilutions of this cytokine were prepared in CMF-PBS with 0.1% BSA. Chemotaxis assayHeparinised human venous blood from healthy volunteers was layered on to Ficoll-Conray (specific gravity 1.078) and centrifuged at 400 g for 30 min. Polymorphonuclear cell (PMN)-rich pellets were collected and the contaminating erythrocytes were lysed by treatment with 0.85% (w/v) NH4Cl (pH 7.0) for 5 min at room temperature. The PMN were then washed three times and suspended in RPMI1640 medium at 1 x 106 cellsml-'. PMN contained more than 92% neutrophils and 5% eosinophils, and the viability was confirmed to be more than 98% by trypan blue dye exclusion.Neutrophil chemotaxis activity experiments were set up in multiwell chemotasis chambers (Neuro Probe. Inc., Bethesda, MD) (Harvath et al., 1980). Briefly, 25 gl aliquots of specimens in CMF-PBS with 0.1% BSA were placed into triplet wells. A polycarbonate filter with 3 ytm pores (polyvinylpyrrolidone-free, Nucleopore Corp., Ple...

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Inflammatory fibrous histiocytoma—An aggressive and lethal lesion

Cited by 213 publications

References 14 publications

Malignant Fibrous Histiocytoma of Soft Tissue Producing Granulocyte Colony-Stimulating Factor.

Malignant Fibrous Histiocytoma of Soft Tissue Producing Granulocyte Colony-Stimulating Factor.

Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation

Neutrophil chemotactic factors produced by malignant fibrous histiocytoma cell lines

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