Retroperitoneal Soft Tissue Sarcoma: Prognostic Factors and Therapeutic Approaches

Pacelli, Fabio; Tortorelli, Antonio Pio; Rosa, Fausto; Papa, Valerio; Bossola, Maurizio; Sánchez, Alejandro Martín; Ferro, Alessandra; Menghi, Roberta; Covino, Marcello; Doglietto, Giovanni Battista

doi:10.1177/030089160809400410

Cited by 18 publications

(21 citation statements)

References 28 publications

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“…Less than 5% of STS arise in the genitourinary tract and only 15% of STS arise within the retroperitoneum [2,7] . All retroperitoneal STS are considered deep lesions with a generally poor prognosis [8,9] .…”

Section: Discussionmentioning

confidence: 99%

Role of Surgical Resection in Adult Urological Soft Tissue Sarcoma: 25-Year Experience

Izumi¹,

Mizokami²,

Sugimoto³

et al. 2010

Urol Int

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Introduction: As adult urological soft tissue sarcomas (STS) are rare, there have been few recent large-scale studies of these tumors. This report describes a single institutional experience of adult urological STS over 25 years. Patients and Methods: The study population consisted of 25 adult patients with histologically diagnosed STS arising in the urinary tract, male genital system, or retroperitoneum between January 1983 and July 2008. The study endpoint was overall survival. The crude probability of survival was estimated using the Kaplan-Meier method. Uni- and multivariate analysis of differences between patient groups was performed with the log rank test and the Cox proportional hazards model. Results: Overall survival rate at 5 years was 54.2%. On univariate analysis, unfavorable prognostic variables for overall survival were presence of metastasis at diagnosis (p = 0.0005), absence of surgical resection (p = 0.0003), histological subtype of rhabdomyosarcoma (p = 0.0068), and primary organs other than retroperitoneum (p = 0.0410). On multivariate analysis, absence of surgical resection remained a significant predictor of unfavorable prognosis (HR 2.67, 95% CI 1.03–7.76, p = 0.044). Conclusions: Surgical resection, regardless of status of surgical resection margin, contributed to a favorable prognosis in adult patients with locally advanced or metastatic urological STS.

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Section: Discussionmentioning

confidence: 99%

Role of Surgical Resection in Adult Urological Soft Tissue Sarcoma: 25-Year Experience

Izumi¹,

Mizokami²,

Sugimoto³

et al. 2010

Urol Int

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“…Leiomyosarcoma is an aggressive soft tissue sarcoma, which mainly originates from the smooth muscle cells of the various body organs and structures including uterus, gastrointestinal tract, soft tissue and large blood vessels [1,2,4]. Leiomyosarcoma has specific clinical, pathohistological and radiographic features.…”

Section: Discussionmentioning

confidence: 99%

“…They represent 1-1.5% of all malignancies in adults. Approximately 10-15% of soft tissue sarcomas arise from the retroperitoneum [1]. Histologically, the most common types are liposarcoma, fibrosarcoma, rhabdomyosarcoma, leiomyosarcoma and angiosarcoma [2].…”

Section: Introductionmentioning

confidence: 99%

“…Occasionally, retroperitoneal tumors may grow very large before the first clinical symptoms occur. The symptoms are often non-specific, or may be the result of infiltration or pressure on surrounding structures [1]. As ultrasound scanning is often inconclusive, in most cases magnetic resonance imaging (MRI) enables both determination of the exact location of the tumor mass, and its relation to surrounding structures, including nerves and large blood vessels.…”

Section: Introductionmentioning

confidence: 99%

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Pelvic Leiomyosarcoma obstructing vaginal opening — case report

Terzić¹,

Aksam²,

Bila³

et al. 2012

Open Medicine

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AbstractWe present a 42-year-old female admitted for a 4 month history of increasing pelvic discomfort and pain. Clinical examination revealed a large tumor obstructing the vagina. Tumor markers (CA 125, CEA, AFP and CA 19-9), white blood cells and biochemical tests were all within the normal limits. Pelvic ultrasound and magnetic resonance imaging scan confirmed the presence of a large retroperitoneal/pelvic mass. The tumor was surgically excised and pathohistologically diagnosed as a well differentiated leiomyosarcoma, staged IB. Six years after surgery the patient is well and disease free.

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“…The clinical characteristics of retroperitoneal and abdominal/visceral STS have been reported mostly from high-volume centers in the United States and Europe [3,4,[6][7][8]. Tumor size is considered to be one of the most important prognostic factors in STS [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Abdominal soft tissue sarcoma: a multicenter retrospective study

et al. 2010

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Retroperitoneal Soft Tissue Sarcoma: Prognostic Factors and Therapeutic Approaches

Abstract: The present study confirmed the importance of an aggressive surgical management for retroperitoneal sarcomas to offer these patients the best chance for long-term survival.

Cited by 18 publications

References 28 publications

Role of Surgical Resection in Adult Urological Soft Tissue Sarcoma: 25-Year Experience

Role of Surgical Resection in Adult Urological Soft Tissue Sarcoma: 25-Year Experience

Pelvic Leiomyosarcoma obstructing vaginal opening — case report

Abdominal soft tissue sarcoma: a multicenter retrospective study

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