Retroperitoneal soft tissue sarcoma

Mendenhall, William M.; Zlotecki, Robert A.; Hochwald, Steven N.; Hemming, Alan W.; Grobmyer, Stephen R.; Cance, William G.

doi:10.1002/cncr.21264

Cited by 149 publications

(111 citation statements)

References 17 publications

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“…Approximately 50% of the STS patients will succumb to their disease because of metastasis or local relapse (2). The prognostic factors determining tumor progression and ultimately the patients' fate include tumor grade, size, location, depth, histological entity, positive resection margins and presence of local recurrence (3)(4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas

Valkov

Sørbye²,

Kilvaer³

et al. 2011

Int J Oncol

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Section: Introductionmentioning

confidence: 99%

Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas

Valkov

Sørbye²,

Kilvaer³

et al. 2011

Int J Oncol

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“…8,[10][11][12][13] After undergoing macroscopically complete surgery alone, local recurrences develop in 20% to 75% of patients, and these can occur even after 5 years of follow-up. 1,8,10,[14][15][16][17][18][19] The estimated survival rate at 5 years varies between 12% and 75%, 6,13,20,21 and the cause of death for these patients usually is local recurrence, which is in sharp contrast to outcomes for patients with sarcoma of the extremities. 8,22 There is much controversy concerning the role of radiotherapy (RT) in the treatment of RSTS.…”

mentioning

confidence: 99%

“…1,8,10,[14][15][16][17][18][19] The estimated survival rate at 5 years varies between 12% and 75%, 6,13,20,21 and the cause of death for these patients usually is local recurrence, which is in sharp contrast to outcomes for patients with sarcoma of the extremities. 8,22 There is much controversy concerning the role of radiotherapy (RT) in the treatment of RSTS. Opponents argue that the lack of an overall survival (OS) benefit renders RT a treatment of little value.…”

mentioning

confidence: 99%

Radiotherapy and surgery—An indispensable duo in the treatment of retroperitoneal sarcoma

Voorde

Delrue

Eijkeren

et al. 2011

Cancer

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The authors undertook a systematic review to designate the role that radiotherapy (RT) might play in the treatment of retroperitoneal sarcomas. Correlating with recent literature, the objective of this review was to evaluate whether there was enough evidence for the authors to develop an institutional treatment protocol concerning the use of RT in the treatment of retroperitoneal sarcoma. Furthermore, this was a call for surgeons to talk to radiation oncologists before performing surgery. The 2 objectives of this review were: 1) to determine the benefit of RT in terms of local control and/or survival in the treatment of retroperitoneal sarcomas and 2) to discover the optimal timing of RT in the treatment sequence. A computerized literature search was performed in the PubMed database, the Cochrane Library database, and reference lists; and journals also were searched by hand to identify all retrospective and prospective reports published since 1998 relating to RT treatment of adult retroperitoneal sarcoma. Mainly, analyses were sought that were based on a 5-year local control rate (LCR), 5-year disease-free survival, and 5-year overall survival (OS). If only 2 years follow-up were available, then the authors also noted this outcome. Toxicity data were collected and analyzed separately. The synthesis of the literature was based on 9 prospectively nonrandomized studies and 10 retrospective studies that, together, reviewed a total of 1426 patients. The 5-year LCR varied from 27% to 62%, and the results from other reports fell in between those values. The 5-year OS rate ranged from 12% to 90%, and complete resection and tumor grade were the most important prognostic factors in most studies. This review resulted in 7 recommendations concerning the use of RT in the treatment of retroperitoneal sarcoma. The authors concluded that there is good evidence from multiple single-institutions studies that RT improves the LCR in patients with retroperitoneal sarcoma. Until now, there has not been a translation of this approach into survival benefit. The current results indicated that preoperative external-beam RT followed by radical surgery seems to be the preferred sequence, and adding intraoperative RT is a safe procedure for dose escalation in the upper abdomen. Cancer 2011;117:4355-

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“…However, a study reported that even when combined resection of surrounding organs was performed, approximately 50% of soft tissue sarcoma cases showed local recurrence and 20% to 30% cases were found to have distant metastasis [9]. The mainstay of treatment is early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Leiomyosarcoma in an Aged Japanese Woman: A Rare Case Report

Aoki¹,

Tanaka²,

Suzuki³

et al. 2017

J Clin Case Rep

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Primary adrenal leiomyosarcoma is an extremely rare tumor. Here, we report the case of a primary adrenal leiomyosarcoma in an 81-year-old woman. Computed tomography showed a right adrenal tumor (7 cm). There were no abnormal findings on physical examination and her serum adrenal hormone levels were normal. However, 67Gallium scintigraphy showed gallium accumulation at the site of a right adrenal tumor, and malignancy was suspected. The right adrenal tumor was surgically removed and histological examination revealed that it was a leiomyosarcoma. After surgical treatment, the patient was administered different types of chemotherapy but she died of local recurrence 1 year later.

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Retroperitoneal soft tissue sarcoma

Cited by 149 publications

References 17 publications

Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas

Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas

Radiotherapy and surgery—An indispensable duo in the treatment of retroperitoneal sarcoma

Primary Adrenal Leiomyosarcoma in an Aged Japanese Woman: A Rare Case Report

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