Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas

Valkov, Andrej; Sørbye, Sveinung Wergeland; Kilvaer, Thomas K.; Dønnem, Tom; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove

doi:10.3892/ijo.2011.920

Cited by 19 publications

(23 citation statements)

References 20 publications

(25 reference statements)

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“…In our previous work we have shown that ER and PGR expression possess variable prognostic significance depending on gender, both per se and in co-expression with TGF-β, fascin and Akt isoforms [7-9]. In the present study, the prognostic diversity of Skp2, ER and PGR in men and women was seen in the different co-expression profiles: female patients with Skp2 positive / ER negative profile had decreased survival rates.…”

Section: Discussionsupporting

confidence: 53%

“…We have modified the Allred score for STS and used 1% positivity as cut-off value [7,16]. The strong and moderate (score 3 and 2, respectively) hormone receptor expression occurred mostly in sarcomas of uterus, pelvis and breast, while the weak (score 1) expression of both ER and PGR was surprisingly evenly distributed among location, gender and age.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, this correlation was statistically significant in females only, not in males. This may be related to differences in expression of sexual hormone receptors (ER and PGR) in male and female STS patients [7,8]. In previous studies, we have shown the prognostic value of female steroid hormone receptors in STSs, both alone and in coexpression with TGF-β, fascin and Akt isoforms [7-9].…”

Section: Introductionmentioning

confidence: 99%

“…This may be related to differences in expression of sexual hormone receptors (ER and PGR) in male and female STS patients [7,8]. In previous studies, we have shown the prognostic value of female steroid hormone receptors in STSs, both alone and in coexpression with TGF-β, fascin and Akt isoforms [7-9]. Such prognostic impact is not surprising, since both ER and PGR regulate growth and cell differentiation upon ligand-dependent and ligand-independent activation and are in essence growth factors.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas

et al. 2013

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BackgroundS-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Skp2 has been demonstrated to display an oncogenic function since its overexpression has been observed in many human cancers. Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant therapy. The prognostic significance of Skp2 related to ER and PGR in STS has not been sufficiently investigated.MethodsTissue microarrays from 193 STS patients were constructed from duplicate cores of viable and representative neoplastic tumor areas. Immunohistochemistry was used to evaluate the expression of Skp2, ER and PGR.ResultsIn univariate analyses, high tumor expression of Skp2 correlated (p = 0.050) with reduced disease-specific survival (DSS). In subgroup analyses expression of PGR in males (p = 0.010) and in patients older than 60 years (p = 0.043) were negative prognostic factors for DSS. Expression of ER in females was a positive prognostic factor for DSS (p = 0.041). In co-expression analyses in the whole cohort, low expression of Skp2 in combination with low expression of ER was positive for DSS (p = 0.049). In females high expression of Skp2 in combination with low expression of ER was a negative prognosticator (p = 0.021). In the multivariate analyses, age (p = 0.012), malignancy grade (p < 0.001), wide resection margins (P = 0.010), ER negative / PGR positive co-expression profile (p = 0.002) and ER positive / PGR negative co-expression profile (p = 0.015) were independent negative prognostic factors for DSS. In females expression of Skp2 (p = 0.006) was associated with shorter DSS.ConclusionsWe found diverse prognostic impacts of expression of Skp2, ER, PGR and DSS in male and female patients with STS. In men, but not women, ER positive / PGR negative co-expression profile was an independent negative prognostic factor for DSS. In women, but not men, high expression of Skp2 was associated with reduced DSS.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas

et al. 2013

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“…showed that estrogen receptor positivity was a significant favorable indicator for disease-specific survival in women ( P = 0.017), while progesterone receptor positivity had inverse impact in men ( P = 0.001). [ 19 ] The impact of gender on survival in STS is unclear and needs to be confirmed by other studies.…”

Section: Discussionmentioning

confidence: 99%

Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors

Iqbal

Shukla

Deo

et al. 2016

Indian J Med Paediatr Oncol

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Background:Data concerning treatment outcome and prognostic factors in sarcomas of abdomen and pelvis are sparse in literature. Methods and Results:Of 696 patients with nonrhabdomyosarcomatous soft tissue sarcoma registered at our center between June 2003 and December 2012, 112 (16%) patients of sarcomas arising from abdomen and pelvis were identified, of which 88 patients were analyzed for treatment outcome and prognostic factors. The median age was 40 years (range: 1–78 years) with a male: female ratio of 0.7:1. Twenty-one (24%) patients were metastatic at baseline. The most common tumor sites were retroperitoneum in 70% patients and abdominal wall in 18% patients. Leiomyosarcoma was the most common histological subtype in 36% patients followed by liposarcoma in 17% patients. Thirty-five (40%) patients had Grade III tumors. Forty-six (52%) patients underwent surgical resection. At a median follow-up of 43 months (range: 2–94 months), the 5-year event-free survival (EFS) and overall survival (OS) were 35% and 42%, with a median of 22 months and 43 months, respectively. Multivariate analysis identified male gender (P - 0.03, hazard ratio [HR] - 0.46, 95% confidence interval [CI] - 0.23–0.92), baseline metastatic disease (P - 0.01, HR - 2.98, 95% CI - 1.27–6.98) and Grade III tumors (P - 0.02, HR - 1.84, 95% CI - 1.08–3.13) as factors associated with poor EFS, whereas baseline metastatic disease (P < 0.001, HR - 5.45, 95% CI - 2.31–12.87) and unresectability (P - 0.01, HR - 2.72, 95% CI - 1.27–5.83) were associated with poor OS.Conclusion:This is a single-institutional study of patients with abdominopelvic sarcomas where gender was identified as a new factor affecting survival apart from baseline presentation, histologic grade, and surgical resection.

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Co-occurrence of a metastatic mammary liposarcoma and an ovarian sex-cord stromal tumor in a dog

Polinas

Burrai

Marras

et al. 2016

Research in Veterinary Science

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Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas

Abstract: Abstract. Estrogen (ER) and progesterone receptor (PgR) regulate growth and cell differentiation upon ligand-dependent and ligand-independent activation.

Cited by 19 publications

References 20 publications

Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas

Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas

Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors

Co-occurrence of a metastatic mammary liposarcoma and an ovarian sex-cord stromal tumor in a dog

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