Retroperitoneal Lymph Node Dissection (RPLD) in Conjunction with Nephroureterectomy in the Treatment of Infiltrative Transitional Cell Carcinoma (TCC) of the Upper Urinary Tract: Impact on Survival

Radical nephroureterectomy for pathologic T4 upper tract urothelial cancer: can oncologic outcomes be improved with multimodality therapy?

“…LnD might decrease overall tumor burden and allows the immune system and chemotherapeutics to target a smaller number of cancer cells, potentially with greater efficacy (21). Brausi et al demonstrated that LnD performed at the time of RnU significantly improved the survival of patients with invasive UTUC (23). Similarly, a Japanese group found that more complete LnD was associated with survival benefits compared to incomplete or no LnD (24).…”

Nefroureterectomía abierta y laparoscópica en tumores uroteliales del tracto urinario superior: experiencia inicial

“…Éste es un apartado muy controvertido, actualmente en estudio por diferentes grupos. Alguno de ellos indican una posible mejora de la supervivencia en tumores de urotelio infiltrante con una linfadenectomía retroperitoneal amplia, con nivel de evidencia 2b [14][15][16][17] . Nuestra actitud es realizar la linfadenectomía en caso de encontrar adenopatías en las pruebas de imagen o como hallazgo intraoperatorio.…”

Laparoscopic Nephroureterectomy: Oncologic Outcomes

“…On multivariate analysis, complete lymphadenectomy, T stage and grade were significant prognostic factors for cancerspecific survival. Brausi et al (2007) reported retroperitoneal lymph node dissection and T stage as the only independent significant prognostic factors on overall survival [12]. Busby et al (2006) found no difference between ONU and LNU concerning number of lymph nodes retrieved, median number of positive nodes retrieved and median density of positive nodes, showing that lymphadenectomy can be performed in the laparoscopic approach as adequately as in open approach [13].…”