Retroperitoneal Castleman&amp;rsquo;s Disease: A Case Report and Brief Review of Tumors of the Pararenal Area

Ebisuno, Shoichi; Yamauchi, Toshiki; Fukatani, Toshiro; Ohkawa, Tadashi

doi:10.1159/000281496

Cited by 12 publications

(10 citation statements)

References 2 publications

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“…The standard therapy of localized form is surgical excision which is curative when resection is complete and en-bloc . No recurrences have been reported after total excision in the literature as it was the case with our cases [5-7,11,38,40,53,82,90]. Because these lesions are highly vascularised, embolization before surgery could be helpful to minimize blood lost during surgery [5,53].…”

Section: Discussionsupporting

confidence: 51%

Surgical management of abdominal and retroperitoneal Castleman's disease

et al. 2005

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Section: Discussionsupporting

confidence: 51%

Surgical management of abdominal and retroperitoneal Castleman's disease

et al. 2005

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“…An accurate staging of the disease should be performed in order to eliminate the possibility of MCD occurrence, and this can be achieved through clinical examination for the detection of suspicious lymph nodes in the axilla, neck, and groin and CT of the thorax. No recurrences have been reported after total excision [23][24][25][26][27][28][29]. Complete surgical excision is the mainstay of treatment and is virtually curative in all cases reported thus far, with a five-year survival rate approaching 100% [3,30].…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of unicentric and multicentric Castleman’s disease: a report of 52 patients

Gao

et al. 2009

Med Oncol

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Castleman's disease (CD) is a rare disorder characterized by non-cancerous tumor growth that may develop in the lymph node tissue at a single site or throughout the body (Castleman et al. in Cancer 9:822-830, 1956). It involves hyperproliferation of specific B cells that produce the cytokine IL-6. This disorder is often undiagnosed or misdiagnosed. For this reason, only very few patients have been reported, and little information is available in the literature. In hopes of providing a better understanding of this rare disease, this report examines 52 patients with Unicentric Castleman's disease (UCD) and Multicentric Castleman's disease (MCD) treated from 1999-2008 at a single institution. Fifty-two patients with CD, along with their histological diagnoses, were collected. Patients were divided into two groups--the more common UCD and the less common MCD. Relevant clinical, pathological, and laboratory data were examined in order to evaluate treatment responses, with symptom onsets and survival period serving as the endpoints of the assessment. Each of the 48 patients with UCD exhibited benign symptoms and underwent a curative surgical resection with excellent prognosis. All of the four patients with MCD received surgical resection. Three of the four patients relapsed and received radiotherapy and/or chemotherapy. Only one of the three post-treatment patients survived. UCD is manifested in the form of benign, painless, slow lymph node enlargement that is generally asymptomatic. Complete surgical removal is recommended as a course of curative treatment. The multicentric form of CD exhibits a progressive clinical course with potential for malignancy. There is currently no standard therapy for MCD.

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“…Castleman's disease should be taken into consideration when an unusual retroperitoneal mass is found even if it encases the renal pedicle [1]. Extensive surgical procedures could be avoided by correct pre-and intraoperative diagnosis, since this lymphoid tumor has a benign nature.…”

Section: Discussionmentioning

confidence: 99%

“…It usually involves the mediastinum and the etiology is unknown. It is very uncommon in the retroperitoneal area [1]. A case of retroperitoneal Castleman's disease of the hyaline vascular type is reported.…”

Section: Introductionmentioning

confidence: 97%