Retronasal olfactory function in nasal polyposis

Landis, Basile Nicolas; Giger, Roland; Ricchetti, Alma; Leuchter, Igor; Hugentobler, Max Anselme; Hummel, Thomas; Lacroix, Jean‐Silvain

doi:10.1097/00005537-200311000-00026

Cited by 79 publications

(68 citation statements)

References 19 publications

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“…First, in accordance with the literature, our study demonstrated a significant correlation between TS and olfactory function . This relation between TS and olfaction could be a potential confounding source of TS performance in CRS, because patients with CRS generally suffer from hyposmia or anosmia . This is not applicable to our findings, however, as CRS patients performed equally to controls on olfactory identification testing.…”

Section: Discussionmentioning

confidence: 99%

The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis

et al. 2016

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“…From a list of each four items, the participants had to identify each odour using a forced choice paradigm. In the healthy population a mean score of 8.5 is achieved [20]. A score beyond 7 indicates impaired function.…”

Section: Main Outcome Measuresmentioning

confidence: 99%

Psychophysiological and electrophysiological testing of olfactory and gustatory function in patients with multiple sclerosis

Dahlslett

Goektas

Schmidt

et al. 2011

Eur Arch Otorhinolaryngol

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The olfactory (OF) and gustatory function in multiple sclerosis (MS) patients and possible influencing variables of the disease, such as depression or fatigue, were determined. In an open prospective controlled clinical study 30 patients with MS and 30 healthy controls matched for age, sex and smoking-habits were investigated. With Mini Mental State Examination cognitive dysfunction was excluded, with Expanded Disability Status Scale the patient's ability to accomplish the tests was ensured. The severity of depression was measured with the self-reported Beck Depression Inventory. The orthonasal olfactory function was derived with olfactory event related potentials (OERP) and TDI-score (Threshold, Discrimination and Identification, Sniffin' Sticks). Retronasal olfactory function was tested with Taste-Powder-score, gustatory function with Taste-strip-score. There was a significant loss of olfactory function measured with TDI-score [12/30 (40%), p = 0.002] and gustatory function [5/23 (21.7%), p \ 0.001] in MS-patients, 23.8% (5/21) of MS-patients showed hyposmia with OERPs, significantly correlating with the TDI-score (p = 0.03). The Expanded Disability Status scale score inversely correlated with the TDI-score (p = 0.002). This study confirms the incidence of olfactory disorder in MS-patients and reveals a frequent gustatory deficit. The Identification subtest can be proposed as a marker of the OF in MS-patients: it includes complex cognitive tasks and may be influenced by depression and fatigue, which are common symptoms of MS. It inversely correlates with the disability status.

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“…The scores in between are considered to reflect hyposmia. Patients 1 and 2 underwent further retronasal olfactory testing [13,14] and patient 1 underwent assessment of chemosensory event-related potentials [15].…”

Section: Olfactory Testingmentioning

confidence: 99%

Olfactory dysfunction following herpetic meningoencephalitis

2009

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Herpetic meningoencephalitis (HME) is a rare but often lethal herpes simplex infection. Patients who survive generally retain neurological deficits. The literature consists mostly of autopsy reports and consistently shows the peripheral and central olfactory pathways to be severely damaged. Little information is available on degree and recovery of olfactory impairment following HME. In this retrospective case series, three patients (two women, one man) who had survived HME were tested with standardized olfactory tests (Sniffin' Sticks) and were followed up more than 3 years after the infectious episode. Initially, all patients showed bilateral functional anosmia and no patient recovered normal olfactory function. Despite total smell loss, various patterns of olfactory deficits were found, with one patient having difficulty identifying odors despite present odor detection thresholds, and two patients lacking odor threshold detection ability. In conclusion, the present findings show that olfactory function is often permanently damaged in patients who have had HME. Lesions lead to various patterns of olfactory loss. Together with histological and clinical data from the literature this suggests further that the olfactory pathway plays a major role in the spread of herpetic meningoencephalitis. It also raises the question whether the olfactory epithelium serves as an entry into the brain for other pathogens.

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Retronasal olfactory function in nasal polyposis

Abstract: Better retronasal than orthonasal olfactory function seems to be associated with the presence of mechanical obstruction in the anterior portion of the olfactory cleft. In turn, these data indicate that olfactory loss in NP seems to be caused by regional mechanical or inflammatory factors.

Cited by 79 publications

References 19 publications

The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis

The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis

Psychophysiological and electrophysiological testing of olfactory and gustatory function in patients with multiple sclerosis

Olfactory dysfunction following herpetic meningoencephalitis

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