Retrodental Mass in Rheumatoid Arthritis

Yonezawa, Ikuho; Okuda, Takatoshi; Won, Jonghwa; Sakoda, Junta; Nakahara, Daishi; Nojiri, Hidetoshi; Muto, Osamu; Momomura, Rei

doi:10.1097/bsd.0b013e3182621a05

Cited by 20 publications

(10 citation statements)

References 10 publications

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“…22,24 On the other hand, retro-odontoid pseudotumors in patients with RA are typically visualized as being hypo-to iso-intense on T1 and hyperintense on T2-weighted MRI. 7, [10][11][12]27 Yonezawa et al, 25 however, reported 3 types of retro-odontoid masses on MRI in patients with RA: pannus type (T1 low, T2 high), pseudotumor type (T1 low, T2 low), and mixed type (T1 low, T2 low and high). High signal intensity on T2-weighted images indicates that the pseudotumor consists of an increased amount of water, as in inflammatory tissue, and low signal intensity T2-weighted images indicates that the pseudotumor contains fibrous material.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with retro-odontoid soft-tissue thickness in rheumatoid arthritis

Dohzono¹,

Suzuki²,

Koike³

et al. 2016

SPI

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OBJECTIVE Increasing soft-tissue mass posterior to the odontoid process causes spinal cord compression. Retro-odontoid pseudotumors are considered to be associated with atlantoaxial instability in patients with rheumatoid arthritis (RA), but the exact mechanism by which these lesions develop has not been elucidated. The purpose of this study was to identify the relationships between retro-odontoid soft-tissue (ROST) thickness and radiological findings or clinical data in patients with RA. METHODS A total of 201 patients with RA who had been followed up at the outpatient clinic of the authors' institution were enrolled in this study. ROST thickness was evaluated on midsagittal T1-weighted MRI. The correlations between ROST thickness and radiographic findings or clinical data on RA were examined. The independent factors related to ROST thickness were analyzed using stepwise multiple regression analysis. RESULTS The average thickness of ROST was 3.0 ± 1.4 mm. ROST thickness showed an inverse correlation with disease duration (r = −0.329, p < 0.01), Steinbrocker stage (r = −0.284, p < 0.01), the atlantodental interval (ADI) in the neutral position (r = −0.326, p < 0.01), the ADI in the flexion position (r = −0.383, p < 0.01), and the ADI in the extension position (r = −0.240, p < 0.01). On stepwise multiple regression analysis, ADI in the flexion position and Steinbrocker stage were independent factors associated with ROST thickness. CONCLUSIONS Although the correlations were not strong, ROST thickness in patients with RA was inversely correlated with ADI and Steinbrocker stage. In other words, ROST thickness tends to be smaller as atlantoaxial instability and peripheral joint destruction worsen. Clinical trial registration no.: UMIN000000980 (UMIN Clinical Trials Registry)

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Section: Discussionmentioning

confidence: 99%

Factors associated with retro-odontoid soft-tissue thickness in rheumatoid arthritis

Dohzono¹,

Suzuki²,

Koike³

et al. 2016

SPI

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“…Moreover, neurological deterioration has also been reported to occur in the setting of rheumatic disease due to inflammatory involvement of the atlantoaxial articulation and retrodental pannus formation [4,12,17,19,20]. Although the cervical spine is a common site of rheumatoid disease manifestation, there is paucity of literature on isolated C1-C2 involvement, especially in the elderly population without evidence of previous rheumatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…The most common type of incomplete spinal cord injury is central cord syndrome, which is characterized by a more severely impaired motor function in the upper than the lower extremities [1,8,10,13,16]. Progressive neurological deficit has also been reported to occur due to C1-C2 pannus formation in the setting of rheumatic disease [4,12,17,19,20].…”

Section: Introductionmentioning

confidence: 99%

Recovery after Cervical Decompression Surgery for the Treatment of Crowned Dens Syndrome Causing Progressive Neurological Decline: A Case Report

Aichmair

Herzog

Perino

et al. 2014

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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“…The critical mediators in RA are considered to be pro-inflammatory cytokines such as RANKL, TWEAK and granulocyte macrophage colony stimulating factor (GM-CSF) [ 17 – 19 ]. Progressive erosion of bone in the affected sites manifests as a pseudotumoral condition of the synovium called pannus where all these complex cascades of events occur [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synovial fluid proteome in rheumatoid arthritis

et al. 2016

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BackgroundRheumatoid arthritis (RA) is a chronic autoinflammatory disorder that affects small joints. Despite intense efforts, there are currently no definitive markers for early diagnosis of RA and for monitoring the progression of this disease, though some of the markers like anti CCP antibodies and anti vimentin antibodies are promising. We sought to catalogue the proteins present in the synovial fluid of patients with RA. It was done with the aim of identifying newer biomarkers, if any, that might prove promising in future.MethodsTo enrich the low abundance proteins, we undertook two approaches—multiple affinity removal system (MARS14) to deplete some of the most abundant proteins and lectin affinity chromatography for enrichment of glycoproteins. The peptides were analyzed by LC–MS/MS on a high resolution Fourier transform mass spectrometer.ResultsThis effort was the first total profiling of the synovial fluid proteome in RA that led to identification of 956 proteins. From the list, we identified a number of functionally significant proteins including vascular cell adhesion molecule-1, S100 proteins, AXL receptor protein tyrosine kinase, macrophage colony stimulating factor (M-CSF), programmed cell death ligand 2 (PDCD1LG2), TNF receptor 2, (TNFRSF1B) and many novel proteins including hyaluronan-binding protein 2, semaphorin 4A (SEMA4D) and osteoclast stimulating factor 1. Overall, our findings illustrate the complex and dynamic nature of RA in which multiple pathways seems to be participating actively.ConclusionsThe use of high resolution mass spectrometry thus, enabled identification of proteins which might be critical to the progression of RA.Electronic supplementary materialThe online version of this article (doi:10.1186/s12014-016-9113-1) contains supplementary material, which is available to authorized users.

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Retrodental Mass in Rheumatoid Arthritis

Cited by 20 publications

References 10 publications

Factors associated with retro-odontoid soft-tissue thickness in rheumatoid arthritis

Factors associated with retro-odontoid soft-tissue thickness in rheumatoid arthritis

Recovery after Cervical Decompression Surgery for the Treatment of Crowned Dens Syndrome Causing Progressive Neurological Decline: A Case Report

Synovial fluid proteome in rheumatoid arthritis

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