Retraction Note to: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis

Liang, Yiran; Song, Xinwei; Li, Yaming; Chen, Bing; Zhao, Wenjing; Wang, Limin; Zhang, Hanwen; Liu, Ying; Han, Dianwen; Zhang, Ning; Ma, Tingting; Wang, Yajie; Ye, Fangzhou; Luo, Dan; Li, Xiaoyan; Yang, Qifeng

doi:10.1186/s12943-022-01576-y

Cited by 35 publications

(48 citation statements)

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“…Caliper detection was carried out every 10 days, and tumor volume ( V ) was calculated using the formula volume = (length × width 2 )/2. At day 40, mice were killed, and tumors were excised, weighed, and fixed in formalin for IHC staining with Ki67 antibody as described previously [12] or prepared for gene measurements using qRT-PCR and Western blot.…”

Section: Methodsmentioning

confidence: 99%

Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma

Zhao¹,

Zhang²

2022

Nephron

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Background: The dysregulation of circular RNAs (circRNAs) has been shown to be correlated with the aggressiveness of renal cell carcinoma (RCC). Hence, this study investigated the role and mechanism of circ_0039569 in RCC progression. Methods: The levels of circ_0039569, miR-133b, and MARCKS (myristoylated alanine-rich protein kinase C substrate) were detected using quantitative real-time polymerase chain reaction and Western blot. In vitro experiments were conducted by using 5-ethynyl-2′-deoxyuridine assay, colony-formation assay, Transwell assay, flow cytometry, and Western blot. The direct interactions between miR-133b and circ_0039569 or MARCKS were verified by using dual-luciferase reporter and pull-down assays. Xenograft mice models were established to conduct in vivo analysis. Results: Circ_0039569 was highly expressed in RCC tissues and cells. Functionally, silencing of circ_0039569 suppressed cell proliferation, migration, and invasion, but induced cell apoptosis in RCC cells in vitro. Moreover, mice subcutaneous xenograft assay suggested that circ_0039569 knockdown impeded tumor growth in vivo. Mechanistically, circ_0039569 acted as a sponge for miR-133b to regulate the expression of its target MARCKS. Importantly, miR-133b inhibition or MARCKS knockdown attenuated the anticancer effects of circ_0039569 knockdown on RCC growth. Conclusion: Diminished circ_0039569 restrains the growth and propagation of RCC cells via miR-133b/MARCKS axis, indicating an underlying effective therapeutic target for RCC patients.

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Section: Methodsmentioning

confidence: 99%

Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma

Zhao¹,

Zhang²

2022

Nephron

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“…According to the literature (29), the association between lncCCAT1 and PKM2 was determined using the Magna RIP RBP IP kit (cat. no.…”

Section: Rip Assaymentioning

confidence: 99%

“…Co-IP. Co-IP was performed as reported previously (29), and western blotting analysis was performed on input samples and IP samples. Co-IP verified the effect of lncCCAT1 on the interaction between Cdc25A and PKM2 using PhosphoSitePlus (https://www.phosphosite.org/homeAction) and NetPhos-3.1 (https://services.healthtech.dtu.dk/service.…”

Section: Rna Pulldown Assaymentioning

confidence: 99%

LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis

Liu

Jing

et al. 2022

Int J Oncol

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Pyruvate kinase M2 (PKM2) plays an important role in the consumption of glucose and the production of lactic acid, the striking feature of cancer metabolism. The association of PKM2 with osteosarcoma (OS) has been reported but its role in OS has yet to be elucidated. To study this, PKM2-bound RNAs in HeLa cells, a type of cancer cells widely used in the study of molecular function and mechanism, were obtained. Peak calling analysis revealed that PKM2 binds to long noncoding RNAs (lncRNAs), which are associated with cancer pathogenesis and development. Validation of the PKM2-lncRNA interaction in the human OS cell line revealed that lncRNA colon cancer associated transcript-1 (lncCCAT1) interacted with PKM2, which upregulated the phosphorylation of sterol regulatory element-binding protein 2 (SREBP2). These factors promoted the Warburg effect, lipogenesis, and OS cell growth. PKM2 appears to be a key regulator in OS by binding to lncCCAT1. This further extends the biological functions of PKM2 in tumorigenesis and makes it a novel potential therapeutic for OS.

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“…Long noncoding RNAs (lncRNAs) play a significant role in the progression of tumors and are abnormally expressed in a variety of cancers [40].…”

Section: Regulation Of Autophagy By Lncrnas In Breast Cancer (Table 1)mentioning

confidence: 99%

“…Current studies have found that some lncRNAs are associated with the metastasis of breast cancer and the resistance to chemotherapy drugs, and some lncRNAs are overexpressed in breast cancer to promote the progression of breast cancer [40]. LncRNAs regulating autophagy through some specific mechanisms can be divided into three categories: lncRNAs bind to miRNAs as competitive endogenous RNAs (ceRNAs) to regulate miRNAs expression, thus affecting autophagy; lncRNAs may affect the expression of Cis-trans ATG genes as well.…”

Section: Regulation Of Autophagy By Lncrnas In Breast Cancer (Table 1)mentioning

confidence: 99%

Crucial Roles of LncRNAs-Mediated Autophagy in Breast Cancer

Han¹,

Mo²,

Yang³

et al. 2022

Int. J. Med. Sci.

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Breast cancer remains a worldwide public health issue. LncRNA and autophagy respectively or simultaneously, get involved in cellular and molecular processes of many different cancers, including genesis, metastasis, and deterioration of breast cancer and other malignant tumors. In this review, relevant studies have been summarized, and we have found that lncRNA-mediated autophagy in luminal A breast cancer, luminal B breast cancer, HER-2 positive breast cancer, and basal-like breast cancer may play an important role in mediating drug resistance sensitivity. LncRNAs target genes and affect different signaling pathways to a complex network, which attenuates the occurrence and development of primary breast cancer by coordinating autophagy. Abnormal expression of LncRNA may lead to dysregulation of autophagy, resulting in tumor genesis, expansion, and resistance to anti-tumor therapy. Targeting specific lncRNAs for autophagy regulation may conduct as a bio-marker for reliable diagnosis and prognosis treatment of breast cancer or provide a promising therapeutic strategy.

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Retraction Note to: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis

Abstract: This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-020-01206-5

Cited by 35 publications

References 0 publications

Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma

Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma

LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis

Crucial Roles of LncRNAs-Mediated Autophagy in Breast Cancer

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