Retraction note: Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients

Ghasemkhani, Naeemeh; Shadvar, Sahar; Masoudi, Yasamin; Talaei, Amir Jouya; Yahaghi, Emad; Goudarzi, Peyman Karimi; Shakiba, Ebrahim

doi:10.1186/s13000-016-0562-7

Cited by 3 publications

(3 citation statements)

References 1 publication

(1 reference statement)

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“…It has become increasingly evident that different miRNAs can play either oncogenic or tumor-suppressive roles in a wide variety of pathways, depending on the target genes or the cellular context (6,7). miR-200c is a member of the miR-200 family, which consists of five members (miR-200a, miR-200b and miR-429 comprise cluster 1, which is located on chromosome 1p36; and miR-200c and miR-141 comprise cluster 2, which is located on chromosome 12p13) (8).…”

Section: Introductionmentioning

confidence: 99%

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Tian

Yue

et al. 2017

Oncology Letters

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Abstract. MicroRNAs (miRNAs/miRs) are a class of small, highly conserved non-coding RNAs that can serve either oncogenic or tumor-suppressive roles in a wide variety of tumors. miR-200c is a member of the miR-200 family whose specific role in non-small cell lung cancer (NSCLC) has not yet been elucidated. The purpose of the present study was to detect the expression level of miR-200c in NSCLC, and to analyze its association with clinicopathological factors and patient prognosis. The present study determined the expression levels of miR-200c in 110 tumor samples collected from patients diagnosed with NSCLC who underwent complete tumor resection with regional lymph node dissection, as assessed by reverse transcription-quantitative polymerase chain reaction. The association between the expression level of miR-200c and clinicopathological features and patient prognosis was also analyzed. The results showed that miR-200c overexpression was detected in 66 of the 110 cases and was significantly associated with positive lymph node metastasis (P<0.001). Univariate survival analysis demonstrated that high miR-200c expression, positive lymph node metastasis and advanced Tumor-Node-Metastasis (TNM) classification stage significantly predicted decreased 5-year disease-free survival rates (all P<0.05) and poor 5-year overall survival rates (all P<0.01), respectively. The results of multivariate Cox regression analysis showed that TNM stage and miR-200c expression retained its significance as an independent prognostic factor for unfavorable 5-year disease-free survival rates (P<0.05) and poor 5-year overall survival rates (P<0.01). The present findings suggest that miR-200c overexpression is significantly associated with poor survival rates in NSCLC and that miR-200c could play an oncogenic role. miR-200c may have clinical potential as a promising prognostic predictor for patients with NSCLC.

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Section: Introductionmentioning

confidence: 99%

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Tian

Yue

et al. 2017

Oncology Letters

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“…Patients with low miR-133a expression had a shorter survival time compared to patients with high miR-133a expression. Thus, reduced miR-133a expression level may be a potential adverse prognostic factor for NSCLC patients (Ghasemkhani et al 2016). In a study by Shen et al (2020) it was found that miR-133a was downregulated in NSCLC cells and tissues, and when its expression was increased, the proliferation of NSCLC cells was inhibited.…”

Section: Discussionmentioning

confidence: 99%

The potential use of miRNAs in the diagnosis and prediction of metastatic lung carcinoma

Skaličanová

Matáková²,

Dzian³

et al. 2022

gpb

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Lung carcinoma is the "top killer" of all malignancies in the world. Early diagnosis of lung carcinoma significantly improves patient survival. Screening with biomarkers from peripheral blood could detect more patients at an early stage of the disease. MicroRNAs (miRNAs) could be a possible biomarker. These are 21-23 nucleotide long single-stranded RNA molecules playing an important role in the post-transcriptional regulation of gene activity. Individual miRNAs have the potential to regulate genes responsible for cell proliferation, differentiation, apoptosis, regulate cell cycle in cooperation with pro-oncogenes and tumor suppressor genes. In our study, we determined miRNA expression levels in individual samples of lung carcinoma patients and in a healthy control group. We used the reverse transcription method followed by qRT-PCR. The expression levels of the investigated miRNAs were evaluated in the QIAGEN GeneGlobe Data center software. We demonstrated the significance of miR-126 and let-7g as biomarkers of lung carcinoma in all clinical stages studied. We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node). The investigated miRNAs showed no clear potential for detecting potentially resectable (N0-N1), locally advanced (N2) and distant organ metastatic (M1) lung carcinoma.

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“…MiRNAs regulate a wide range of pathophysiological processes [14][15][16][17][18]. miR-21 activates various signal pathways to enhance the expression of HIF-1α and VEGF, resulting in angiogenesis [11].…”

Section: Introductionmentioning

confidence: 99%

MiRNA-21-HIF-1α-VEGF Axis Is Associated with Myopic Choroidal Neovascularization in Guinea Pigs

Liu¹,

Zhu²,

Ding³

et al. 2022

Ophthalmic Res

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Introduction: Myopic choroidal neovascularization (mCNV) often causes serious damage to central vision. The mechanisms behind it remain unclear. Method: In this study, monocular form deprivation was applied to induce high myopia and 532 nm laser was employed to induce CNV in guinea pig. The development of neovascularization was measured comprehensively by fundus fluorescein angiography, Optical coherence tomography and HE-staining. Gene expression was detected by real-time polymerase chain reaction and Immunohistochemistry. Results: The proliferation of new blood vessels increased with time and peaked at 21 d. At each time point after laser photocoagulation, the incidence of CNV was higher in form-deprived myopia (FDM) group than in control group. Myopic CNV started earlier and decreased more slowly. The obvious continuous fluorescein leakage could last as long as one month. The expressions of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) increased and peaked at 14 d in both groups after laser photocoagulation. Moreover, after laser photocoagulation, miR-21 expression was upregulated in both groups, reached a peak at 7 d, with a level much higher in FDM group. In addition, miR-21 expression was positively correlated with VEGF and HIF-1α expression in both groups. Conclusion: miR-21 correlated with HIF-1α-VEGF signaling pathway may promote CNV formation in high-myopia guinea.

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Retraction note: Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients

Cited by 3 publications

References 1 publication

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

The potential use of miRNAs in the diagnosis and prediction of metastatic lung carcinoma

MiRNA-21-HIF-1α-VEGF Axis Is Associated with Myopic Choroidal Neovascularization in Guinea Pigs

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