RETRACTED: Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus

Chae, Chang Ho; Jung, S.-L.; An, Sung Yong; Park, B.Y.; Wang, S.W.; Cho, I.H.; Cho, J.Y.; Kim, H.T.

doi:10.1016/j.neuroscience.2009.09.075

Cited by 46 publications

(32 citation statements)

References 61 publications

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“…Importantly, the conversion of AMCC to neurons is accompanied by elevated nerve growth factor (NGF) level and a lack of glucocorticoids (31). Likewise, upregulation of NGF level during exercise has been demonstrated previously (8). We further hypothesize that insufficient circulating EPI levels are caused by NGF-mediated neuron transition of chromaffin cells during exercise.…”

supporting

confidence: 57%

High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells

Feng

Xun

et al. 2013

American Journal of Physiology-Lung Cellular and Molecular Phys

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He R, Feng J, Xun Q, Qin Q, Hu C. High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells. Am J Physiol Lung Cell Mol Physiol 304: L602-L612, 2013. First published February 15, 2013 doi:10.1152/ajplung.00406.2012.-A high prevalence of exercise-induced bronchoconstriction (EIB) can be found in elite athletes, but the underlying mechanisms remain elusive. Airway responsiveness, NGF and epinephrine (EPI) levels, and chromaffin cell structure in high-(HiTr) and moderate-intensity training (MoTr) rats with or without ovalbumin (OVA) sensitization were measured in a total of 120 male Sprague-Dawley rats. The expression of NGF-associated genes in rat adrenal medulla was tested. Both HiTr and OVA intervention significantly increased airway resistance to aerosolized methacholine measured by whole body plethysmography. HiTr significantly increased inflammatory reaction in the lung with a major increase in peribronchial lymphocyte infiltration, whereas OVA significantly increased the infiltration of various inflammatory cells with an over 10-fold increase in eosinophil level in bronchoalveolar lavage. Both HiTr and OVA intervention upregulated circulating NGF level and peripherin level in adrenal medulla, but downregulated phenylethanolamine N-methyl transferase level in adrenal medulla and circulating EPI level. HiTr ϩ OVA and HiTr ϩ ExhEx (exhaustive exercise) interventions significantly enhanced most of the HiTr effects. The elevated NGF level was significantly associated with neuronal conversion of adrenal medulla chromaffin cells (AMCC). The levels of p-Erk1/2, JMJD3, and Mash1 were significantly increased, but the levels of p-p38 and p-JNK were significantly decreased in adrenal medulla in HiTr and OVA rats. Injection of NGF antiserum and moderate-intensity training reversed these changes observed in HiTr and/or OVA rats. Our study suggests that NGF may play a vital role in the pathogenesis of EIB by inducing neuron transdifferentiation of AMCC via MAPK pathways and subsequently decreasing circulating EPI. exercise; asthma; lung; inflammation; NGF; neuron conversion; adrenal medulla EXERCISE-INDUCED BRONCHOCONSTRICTION (EIB) is the increase in airway obstruction with symptoms of coughing, wheezing, or dyspnea as a result of exercise (23). EIB occurs in ϳ11% of the general population without asthma (13). Inhalation of cold air and sudden changes in humidity or temperature have been associated with EIB (20). High prevalence of EIB is usually observed among endurance athletes (7), implicating that intensity of exercise may be associated with EIB.Although thermal and osmotic consequences of water loss play prominent roles in the emergence of EIB (2), more studies are needed to elucidate the underlying mechanism. Circulating epinephrine (EPI), produced by adrenal medulla chromaffin cells (AMCC), is believed to bind the adrenergic receptors of airway smooth muscles to achieve adrenergic bronchodilation, and a loss of this function could directly influence the sev...

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supporting

confidence: 57%

High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells

Feng

Xun

et al. 2013

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…In agreement with this hypothesis, some groups have reported that voluntary or forced exercise changes the activity of various kinases in the hippocampus (e.g. PI3K/Akt, PKC, ERK, p38), even though their results are not always consistent (Chae et al, 2009;Chen and Russo-Neustadt, 2005;Leem et al, 2009). Similarly, our data indicate that long-term exercise significantly increases hippocampal BDNF, a neurotrophin that promotes synaptic plasticity and memory (Cunha et al, 2010;Heldt et al, 2007) and is known to play an important role in the mnesic effects of exercise Neeper et al, 1996;Vaynman et al, 2004Vaynman et al, , 2006.…”

Section: Discussionmentioning

confidence: 89%

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

Bélarbi

Burnouf

Fernandez-Gomez

et al. 2011

Neurobiology of Disease

146

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“…Exercise positively affects cognitive abilities. Treadmill exercise is an important factor for improving cognitive functioning (10).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

Darkhah

Zarghami

Bushehri

et al. 2016

Jentashapir J Health Res

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RETRACTED: Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus

Cited by 46 publications

References 61 publications

High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells

High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

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