RETRACTED: Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways

Nagib, Marwa M.; Tadros, Mariane G.; Al-khalek, Hadwa Ali Abd; Rahmo, Rania M.; Sabri, Nagwa Ali; Khalifa, Amani E.; Masoud, Somaia I.

doi:10.1016/j.neuro.2018.07.006

Cited by 19 publications

(12 citation statements)

References 75 publications

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“…In studies of isolated C2C12 skeletal muscle cells [128], supplementation of CoQ10 with α-lipoic acid enhanced PGC-1α expression and increased genes that encode proteins involved in glutathione synthesis, recycling, and metabolism [134]. These findings are consistent with observations made in a rat model of pharmacologically-induced seizures, whereby administration of CoQ10 reduced oxidant stress by enhancing PGC-1α nearly 3-fold [135]. These changes were also associated with increased levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and silencing information regulator 1 (Sirt1), both of which improve redox control within the cell, by increasing mitochondrial antioxidants such as superoxide dismutase 2.…”

Section: Potential Mechanisms Of Coq 10 Against Oxidant Stresssupporting

confidence: 78%

Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone

Chen

Hocum-Stone

et al. 2021

Antioxidants

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Over 240 million non-cardiac operations occur each year and are associated with a 15–20% incidence of adverse perioperative cardiovascular events. Unfortunately, preoperative therapies that have been useful for chronic ischemic heart diseases, such as coronary artery revascularization, antiplatelet agents, and beta-blockers have failed to improve outcomes. In a pre-clinical swine model of ischemic heart disease, we showed that daily administration of ubiquinone (coenzyme Q10, CoQ10) enhances the antioxidant status of mitochondria within chronically ischemic heart tissue, potentially via a PGC1α-dependent mechanism. In a randomized controlled trial, among high-risk patients undergoing elective vascular surgery, we showed that NT Pro-BNP levels are an important means of risk-stratification during the perioperative period and can be lowered with administration of CoQ10 (400 mg/day) for 3 days prior to surgery. The review provides background information for the role of oxidant stress and inflammation during high-risk operations and the potential novel application of ubiquinone as a preoperative antioxidant therapy that might reduce perioperative adverse cardiovascular outcomes.

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Section: Potential Mechanisms Of Coq 10 Against Oxidant Stresssupporting

confidence: 78%

Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone

Chen

Hocum-Stone

et al. 2021

Antioxidants

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“…In studies of isolated C2C12 skeletal muscle cells, supplementation of CoQ 10 with α-lipoic acid enhanced PGC1α expression while increasing genes encoding proteins involved in glutathione synthesis, recycling, and metabolism [33]. These findings are consistent with those from a rat model of pharmacologically induced seizures, where administration of CoQ 10 increased expression of PGC1α levels 3-fold and reduced oxidant stress markers [22]. It has been suggested that CoQ 10 increases the expression and activity of PGC1α by its activation of the cAMP response element binding protein and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation [34].…”

Section: Discussionsupporting

confidence: 53%

“…PGC1α is also reduced within aging muscle, leading to increased oxidant stress within the tissue [21]. Interestingly, PGC1α levels can be increased nearly three-fold by administration of coenzyme Q 10 (CoQ 10 ) or ubiquinone, as shown in a rat model of neurodegenerative disease, with an observed reduction in oxidant stress markers [22]. CoQ 10 is a component of Complex III and the Q-cycle of the mitochondrial ETC, and is essential for ATP production, while reducing the accumulation of reactive oxygen species (ROS) [23].…”

Section: Introductionmentioning

confidence: 99%

CoQ10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium

et al. 2019

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BackgroundExpression of mitochondrial proteins is reduced within hibernating myocardium (HM). It is unclear whether dietary supplementation with CoQ10 can increase expression of mitochondrial electron transport chain (ETC) and antioxidant proteins within this tissue. In a swine model of HM, we tested whether dietary administration of CoQ10 for four weeks enhances the expression of ETC and antioxidant proteins within the mitochondria via increased PGC1α signaling.Methods12 swine were instrumented with a fixed constrictor around the LAD artery to induce gradual stenosis. At three months, transthoracic ECHO was performed to confirm the presence of a wall motion abnormality in the anterior wall. Animals were then randomly assigned to receive daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo for four weeks. At this time, animals underwent a final ECHO and terminal procedure. Expression of nuclear-bound PGC1α (Western blots) and mitochondrial proteins (Tandem Mass Tag) were determined.ResultsMitochondrial and nuclear membranes were isolated from the LAD region. Nuclear-bound PGC1α levels were > 200-fold higher with administration of four weeks of CoQ10 treatment (p = 0.016). Expression of ETC proteins was increased in those animals that received CoQ10. Compared with mitochondria in the LAD region from placebo-treated pigs, CoQ10-treated pigs had higher levels of Complex I (p = 0.03), Complex IV (p = 0.04) and Complex V (p = 0.028) peptides.ConclusionsFour weeks of dietary CoQ10 in HM pigs enhances active, nuclear-bound PGC1α and increases the expression of ETC proteins within mitochondria of HM tissue.

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“…In the current study, an apparent decrease in Nissl granule content was detected in hippocampus neurons in epileptic models (PILO and PILO+LPS). Chromatolysis and reduced Nissl granules were found in Wistar rat neurons, mostly triggered by apoptosis [25]. Feng and his colleagues [14] reported that epilepsy in pilocarpine rat epilepsy models results in mitochondrial dysfunction in hippocampal rat neurons, leading to hippocampal neuron apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation

et al. 2021

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The risk of developing epilepsy is strongly linked to peripheral inflammatory disorders in humans. High-mobility group box protein 1 (HMGB1) has the most focus for being a suspect in this scenario. The current study aimed to detect the celecoxib effect, an anti-inflammatory drug, on decreasing seizure susceptibility and organ damage in lipopolysaccharides (LPS)/pilocarpine (PILO) pretreated Wistar rats. Rats were divided into 6 groups (8 each): group 1 (control), group 2 (PILO), group 3 (PILO+LPS), group 4 (PILO+LPS+(VPA) Valproic acid), group 5 (PILO+LPS+Celecoxib), and group 6 (PILO+LPS+VPA+Celecoxib). LPS was used to induce sepsis and PILO to induce seizures. Oxidative stress markers, pro-inflammatory cytokines, and HMGB1 levels in serum and brain homogenate were evaluated. Histopathological studies were conducted on the hippocampus, liver, lung, and kidney. Treatment with celecoxib either alone or in combination with VPA significantly reduced Racine score and delays latency to generalized tonic-clonic seizures onset with a significant decrease in hippocampal levels of pro-inflammatory cytokines, oxidative stress markers, and increase in reduced glutathione. In addition, celecoxib treatment either alone or in combination with VPA suppressed HMGB1translocation into peripheral circulation more than treatment with VPA alone. Furthermore, hippocampus, liver, lung, and kidney histopathological changes were improved in contrast to other epileptic groups. Celecoxib either alone or combined with VPA has antiepileptic and multiorgan protective effects on acute seizures and inflammatory models induced by PILO with LPS. It decreased histopathological findings, oxidative, and inflammatory effects induced by VPA and LPS. This might be due to its anti-oxidative, anti-inflammatory and anti-HMGB1 mediated effects.

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RETRACTED: Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways

Cited by 19 publications

References 75 publications

Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone

Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone

CoQ10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium

Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation

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