RETRACTED: MiR-361-5p inhibits the mobility of gastric cancer cells through suppressing epithelial-mesenchymal transition via the Wnt/β-catenin pathway

Tian, Li; Zhao, Zhifeng; Xie, Lin; Zhu, Jinpeng

doi:10.1016/j.gene.2018.06.095

Cited by 27 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Wnt/β-catenin pathway has been reported to have an important role in EMT (25). For example, Tian et al (26) demonstrated that miR-361-5p inhibits the mobility of gastric cancer cells through suppressing EMT via the Wnt/β-catenin pathway. Yuan et al (27) identified that rhomboid 5 homolog 1 regulates the APC-mediated stimulation of EMT and also proliferation of colorectal cancer cells via the Wnt/β-catenin pathway.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are hypothesized to regulate numerous biological behaviors in human cancers. The present study aimed to explore the roles of lncRNA bladder cancer associated transcript 1 (BLACAT1) in glioma. The expression of BLACAT1 in glioma tissues and cell lines was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). CCK-8 assay, colony formation assay, wound healing assay and Transwell invasion assay were used to explore the roles of BLACAT1 in glioma cells. RT-qPCR and western blot analysis were used to determine the BLACAT1 molecular mechanism. The findings demonstrated that lncRNA BLACAT1 was overexpressed in glioma tissues and cell lines. High BLACAT1 expression was correlated with high tumor grade in glioma patients. Functional assays determined that BLACAT1 promoted glioma cell proliferation, migration, invasion and epithelial-mesenchymal transition in vitro. In addition, it was demonstrated that BLACAT1 activated the Wnt/β-catenin signaling pathway. In conclusion, BLACAT1 may serve as an oncogenic lncRNA in glioma progression via activation of the Wnt/β-catenin signaling pathway. Therefore, BLACAT1 may be a novel therapeutic target for glioma treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Owing to the mutuality amongst EMT and Wnt/β‐catenin pathway in GC pathogenesis, researchers are making efforts to excavate potential molecules as therapeutic targets for more specific treatment. Recent studies have established that miRNAs are involved in the regulation of Wnt/β‐Catenin pathway in GC, for instance, miRNA‐361‐5p inhibited GC cell proliferation both in vitro and in vivo through suppression of EMT through the Wnt/β‐catenin pathway . Moreover, a recent study clearly showed that SUFU, a known negative regulator of Wnt signaling, was a target of miRNA‐194, actually miRNA‐194 enhanced GC cell proliferation and migration through stimulating Wnt/β‐catenin signaling cascades, partially via inhibiting SUFU .…”

Section: Role Of Mirnas In Signaling Pathways Of Gcmentioning

confidence: 99%

“…Moreover, a recent study clearly showed that SUFU, a known negative regulator of Wnt signaling, was a target of miRNA‐194, actually miRNA‐194 enhanced GC cell proliferation and migration through stimulating Wnt/β‐catenin signaling cascades, partially via inhibiting SUFU . MiRNA‐361‐5p inhibited GC cell proliferation both in vitro and in vivo through suppression of EMT via the Wnt/β‐catenin pathway . Many different miRNAs have been implied to be considerable in modulating EMT via Wnt signaling in GC.…”

Section: Role Of Mirnas In Signaling Pathways Of Gcmentioning

confidence: 99%

“…Recent studies have established that miRNAs are involved in the regulation of Wnt/β-Catenin pathway in GC, for instance, miRNA-361-5p inhibited GC cell proliferation both in vitro and in vivo through suppression of EMT through the Wnt/β-catenin pathway. 111 Moreover, a recent study clearly showed that SUFU, a known negative regulator of Wnt signaling, was a target of miRNA-194, 112 actually miRNA-194 enhanced GC cell proliferation and migration through stimulating Wnt/βcatenin signaling cascades, partially via inhibiting SUFU. 112 MiRNA-361-5p inhibited GC cell proliferation both in vitro and in vivo through suppression of EMT via the Wnt/β-catenin pathway.…”

Section: Role Of Mirnas In Signaling Pathways Of Gcmentioning

confidence: 99%

“…112 MiRNA-361-5p inhibited GC cell proliferation both in vitro and in vivo through suppression of EMT via the Wnt/β-catenin pathway. 111 Many different miRNAs have been implied to be considerable in modulating EMT via Wnt signaling in GC. MiRNA-200 family consist of five members such as miR-200a, miR-200b, miR-200c, miR-141, and miR-429 and this family has been appreciably stated to be representative of regulatory factors of EMT via ability of terminating Wnt/β-catenin pathway in GC.…”

Section: Role Of Mirnas In Signaling Pathways Of Gcmentioning

confidence: 99%

See 2 more Smart Citations

Dysregulation of miRNAs as a signature for diagnosis and prognosis of gastric cancer and their involvement in the mechanism underlying gastric carcinogenesis and progression

Ahadi

2020

IUBMB Life

View full text Add to dashboard Cite

Gastric cancer (GC) is the second main cause of cancer‐related mortality worldwide. The poor prognosis and survival of GC are due to diagnosis in an advanced, noncurable stage and with a restricted response to chemotherapy. GC is usually monitored in an advanced stage; therefore, the poor prognosis and lower level of survival rate with a restricted response to chemotherapy can be detected. Valuable and sensible biomarkers are urgently needed to display screen patients with a high risk of GC that can complement endoscopic diagnosis. Such biomarkers will enable the efficient prediction of the therapeutic response and prognosis of GC patients and prefer the establishment of an advantageous treatment method for each and every patient. Noninvasive diagnostic biomarkers may additionally make a contribution to the early identification of GC and enhance medical management. MicroRNAs (miRNAs) are a group of small noncoding RNAs that have displayed a strong association with GC. Accumulating evidence indicates that miRNAs are potential biomarkers with more than one diagnostic function for GC. Actually, miRNAs regulate cell proliferation, apoptosis, migration, invasion, and metastasis via many biological pathways through the repression of target mRNAs. The current review is accordingly to spotlight the multifaceted roles of miRNAs in GC, which would provide indications for future research. Therefore, we review right here the aberrant expression of miRNAs and underlying mechanisms, consequent effects due to miRNAs dysregulation, and accountable target genes in GC. Besides, potential clinical applications are also highlighted.

show abstract

lncRNA HOXC‐AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/β‐catenin signaling

Zhou¹,

Cao

et al. 2020

The Journal of Gene Medicine

View full text Add to dashboard Cite

Background Long non‐coding RNAs (lncRNAs) function as oncogenes or tumor suppressor genes in several cancers. The present study aimed to determine the functions of lncRNA HOXC‐AS1 in gastric cancer (GC) in vitro. Methods A quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR) was used to measure the expression of lncRNA HOXC‐AS1 in GC cell lines and normal cells. After silencing HOXC‐AS1 in GC cells, a cell counting kit‐8 assay monitored the viability of the cells. qRT‐PCR and western blot documented the EMT key genes in response to HOXC‐AS1 change. qRT‐PCR detected mRNA expression for eIF4AIII in GC and normal cell lines and cell viability was measured after an increase and decrease of eIF4AIII. RNA pull‐down and qRT‐PCR confirmed the binding in between. Apoptosis was compared by flow cytometry. The interplay between the two genes was surveyed by introduction of the sh‐HOXC‐AS1 and sh‐eIF4AIII and by assessing cell viability, EMT and Wnt/β‐catenin signaling. Results lncRNA HOXC‐AS1 expression is up‐regulated in GC cells and a decrease of lncRNA HOXC‐AS1 inhibited cell viability. Binding was validated by RNA pull‐down. Additionally, inhibition of eIF4AIII induced an increase of lncRNA HOXC‐AS1, thus promoting cell proliferation and the EMT process but deterring apoptosis of gastric cancer cells. Wnt/β‐catenin signaling was impeded by HOXC‐AS1 inhibition but restored by suppression of eIF4AIII. Conclusions HOXC‐AS1 may promote the proliferation and the EMT process and inhibit apoptosis by binding eIF4AIII via Wnt/β‐catenin signaling, which indicates that HOXC‐AS1/eIF4AIII might be an axis that could be further used as a biomarker to help with the diagnosis of GC.

show abstract

RETRACTED: MiR-361-5p inhibits the mobility of gastric cancer cells through suppressing epithelial-mesenchymal transition via the Wnt/β-catenin pathway

Cited by 27 publications

References 25 publications

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

Dysregulation of miRNAs as a signature for diagnosis and prognosis of gastric cancer and their involvement in the mechanism underlying gastric carcinogenesis and progression

lncRNA HOXC‐AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/β‐catenin signaling

Contact Info

Product

Resources

About