Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

Li, Xiushan; Qi, Shujing; Ma, Dongzhou; Fan, Jinbiao; Wang, Jingtao

doi:10.3892/etm.2019.7468

Cited by 15 publications

(17 citation statements)

References 28 publications

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“…In cervical cancer, the upregulation of NNT‐AS1 enhances cell progression via Wnt signaling transduction . Meanwhile, in glioma cells lncRNA BLACAT1 facilitates GC development via activating Wnt signaling pathway, and CCAT‐1 promotes cell proliferation and suppresses the apoptosis of cells through Wnt/β‐catenin signaling transduction . In our present investigation, Wnt signaling activation has been demonstrated to promote GC metastasis, and LOC285194 suppresses GC progression by blocking Wnt signaling pathway activation.…”

Section: Discussionsupporting

confidence: 51%

“…22 Meanwhile, in glioma cells lncRNA BLACAT1 facilitates GC development via activating Wnt signaling pathway, and CCAT-1 promotes cell proliferation and suppresses the apoptosis of cells through Wnt/β-catenin signaling transduction. 23 In our present investigation, Wnt signaling activation has been demonstrated to promote GC metastasis, and LOC285194 suppresses GC progression by blocking Wnt signaling pathway activation. Since several signaling pathways might be associated with GC, it is of great importance to pay closer attention to other potential signaling pathways that may be related to GC progress in our future investigations.…”

Section: Discussionmentioning

confidence: 50%

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LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β‐catenin signaling pathway

Zhong

Wang

et al. 2020

Cancer Medicine

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Emerging evidences have revealed long noncoding RNAs (lncRNAs’) critical roles in diverse human carcinoma. Among these cancers, lncRNA LOC285194 has been extensively investigated in several types of carcinomas in the recent years. Nevertheless, the biological function, clinical relevance, and the influence of LOC285194 in gastric cancer (GC) are not fully understood. The present study aims to explore the biological function of LOC285194 in the progression and development of GC. First, LOC285194 expressions were detected in GC tissues and cell lines. The functional role of LOC285194 in GC was evaluated both in vitro and in vivo. Our data found that LOC285194 was lowly expressed both in human GC tissues and GC cell lines compared with corresponding normal controls. Moreover, LOC285194 was mitigated by transfection with LV‐LOC285194 in both HGC‐27 and MKN45 cell lines. Silencing of LOC285194 remarkably induced GC cell livability and cell proliferation. On the contrary, the LOC285194 overexpression suppressed MKN45 and HGC‐27 cell proliferation and promoted cell apoptosis. Additionally, silencing of LOC285194 increased the ability of colony formation, cell migration, and invasive capacities, together with blocking the apoptotic rates of GC cells. Correspondently, LOC285194 overexpression exerted the opposite effects. Mechanistically, silencing of LOC285194 promoted GC progression via inducing Wnt signaling activity. Moreover, in vivo xenografts nude mice model results showed that LOC285194 inhibited GC progression through targeting Wnt signaling. Taken together, LOC285194 is associated with GC progression by regulating the Wnt signaling transduction, potentiating LOC285194's promising role as a novel treatment biomarker in GC.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 50%

LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β‐catenin signaling pathway

Zhong

Wang

et al. 2020

Cancer Medicine

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“…They described that BLACAT1 could activate WNT/β-catenin pathway to promote proliferation and invasion of glioma cells. 20 These results showed the potential function of BLACAT1 as a novel oncogenic lncRNA and a prospective therapeutic target in glioma ( Figure 1A).…”

Section: Introductionmentioning

confidence: 80%

“…It was reported to regulate EMT-associated proteins and promote the progression of glioma, cervical cancer, and lung cancer by activating WNT/β-catenin pathway. 20,26,31 Besides, present evidence pointed out that BLACAT1 could interact with STAT3 and enhance the phosphorylation of STAT3, accelerating the proliferation and migration of lung cancer and osteosarcoma. 28,34 However, our understanding of the role of BLACAT1 in tumor biology remains in a preliminary stage, and detailed molecular mechanisms of BLACAT1 are still needed to be systematically explored.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 87%

<p>Long Non-Coding RNA BLACAT1 in Human Cancers</p>

Tao¹,

Yang²,

Liu³

et al. 2020

OTT

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Long non-coding RNAs (lncRNAs) are a cluster of RNAs with more than 200 nucleotides in length, which lack protein-coding capacity. They are important regulators of numerous cellular processes, including gene transcription, translation, and posttranslational modification, especially in tumor initiation and progression. Aberrant expression of lncRNA bladder cancer-associated transcript 1 (BLACAT1) has been reported in various human cancers and was usually associated with unfavorable prognosis. Previous studies have revealed that dysregulation of BLACAT1 could promote the proliferation and metastasis of cancer cells. In this review, we summarize the present understanding of the functions and underlying mechanisms of BLACAT1 in the occurrence and development of various human cancers and discuss the roles of this lncRNA in cancers, including its promising application as a prognostic biomarker or a novel therapeutic target for malignancies.

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“…LncRNA-BLACAT1, also known as linc-UBC1, was a novel long non-coding RNA identified in bladder cancer (10). There are several articles referring the role of lncRNA-BLACAT1 such as poor prognostic biomarker for different cancers (11)(12)(13)(14)(15)(16)(17), chemoresistance in gastric cancer and NSCLC (18,19). However, few studies concerning the role of lncRNA-BLACAT1 in the development of PC.…”

Section: Introductionmentioning

confidence: 99%

LncRNA-BLACAT1 Facilitates Proliferation, Migration and Aerobic Glycolysis of Pancreatic Cancer Cells by Repressing CDKN1C via EZH2-Induced H3K27me3

et al. 2020

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Objective: To investigate the role of lncRNA-BLACAT1 in promoting H3K27 trimethylation of CDKN1C gene by recruiting EZH2 to regulate CCNE on glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer (PC) cells. Methods: Following bioinformatic prediction, EZH2 and BLACAT1 in PC cells were interfered, and cells proliferation, migration and invasion in each group were detected. Western blotting detected the expression of key proteins of mitochondrial complex. The sub-cellular localization of BLACAT1 was tested, followed by testing the binding of CDKN1C and BLACAT1 with EZH2, followed by in vivo verification. Results: Based on bioinformatic prediction, EZH2 and BLACAT1 were highly expressed in PC, while CDKN1C was lowly expressed (all P < 0.05). Interference with EZH2 and BLACAT1 inhibited cell proliferation, migration and aerobic glycolysis, and promoted mitochondrial oxidative phosphorylation (all P < 0.05). BLACAT1 promoted H3K27 trimethylation of CDKN1C through recruiting EZH2 (all P < 0.05). In vivo results showed that BLACAT1 interference inhibited tumor formation (all P < 0.05). Conclusion: Interference with BLACAT1 inhibits H3K27 trimethylation of CDKN1C gene by blocking EZH2 recruitment to promote CDKN1C expression and inhibit CCNE expression, thus suppressing PC cell proliferation, migration and aerobic glycolysis, and promoting mitochondrial oxidative phosphorylation.

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Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

Cited by 15 publications

References 28 publications

LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β‐catenin signaling pathway

LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β‐catenin signaling pathway

<p>Long Non-Coding RNA BLACAT1 in Human Cancers</p>

LncRNA-BLACAT1 Facilitates Proliferation, Migration and Aerobic Glycolysis of Pancreatic Cancer Cells by Repressing CDKN1C via EZH2-Induced H3K27me3

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