RETRACTED: Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats

Mauriz, José L.; Molpeceres, Virginia; García‐Mediavilla, María Victoria; González, Pablo; Barrio, J.P.; González‐Gallego, Javier

doi:10.1111/j.1600-079x.2006.00409.x

Cited by 74 publications

(65 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mel and its metabolites have been found to protect tissues against oxidative damage generated by a variety of toxic agents and metabolic processes [41,43,44]. For example, it was found that Mel protects against adriamycin-induced nephrotoxicity [45], Al toxicity in the brain [46,47] and oxidative stress in the liver of ageing rats [48].…”

mentioning

confidence: 99%

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Contini

Millen

González

et al. 2011

Biol Trace Elem Res

View full text Add to dashboard Cite

This study is designed to determine the simultaneous effect of aluminium (Al) and melatonin (Mel) treatment in intact and ovariectomized (Ovx) female rats on oxidative stress and their inter-organ relationship in the kidney and liver. Al-treated rats received an intra-peritoneal injection of solution of aluminium lactate (0.575 mg Al/100 g of body weight, three times a week), during 12 weeks. Mel groups received intra-peritoneal injections of melatonin at a dose of 10 mg/kg/day, 5 days/week, during 12 weeks. The results of this study showed that Al treatment in female rats modifies homeostasis of glutathione and the antioxidant capacity of the rat liver and kidney. The alteration of glutathione homeostasis and oxidative status was not associated with an increased lipid peroxidation in both organs with the exception of the increase observed in the liver of Ovx rats. Al also induced modifications in the activity of some enzymes related to the glutathione cycle: GSH-Px in the liver and kidney and glutathione reductase only in the kidney. Al exposure decreased CAT activity in both the kidney and liver of intact and Ovx groups. The administration of Mel in the intact and castrated females treated with Al seems to reduce oxidative changes in the liver and kidney of intact and Ovx rats.

show abstract

mentioning

confidence: 99%

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Contini

Millen

González

et al. 2011

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Controversial results have been found in animals exposed to high Cu doses and other oxidative toxics. Decreased SOD activity was appreciated in the liver and/or serum of Cu loaded rats (Roy et al, 2009) that could be due to an increase in protein degradation (Kwon et al, 1998) or nuclear damage caused by Cu toxicity that could affect gene expression, and thus, a decrease of SOD activity (Mauriz et al, 2007;Yu et al, 2008). Thus, according to these authors, the non-increased SOD activity in the Cu-supplemented animals in this study could be explained by the increased protein damage that could lead to a higher SOD degradation.…”

Section: Discussionmentioning

confidence: 99%

Histochemistry evaluation of the oxidative stress and the antioxidant status in Cu-supplemented cattle

García‐Vaquero

Benedito

López‐Alonso

et al. 2012

Animal

View full text Add to dashboard Cite

The aim of this paper is to evaluate at a histopathological level the effect of the most commonly used copper (Cu) supplementation (15 mg/kg dry matter (DM)) in the liver of intensively reared beef cattle. This was done by a histochemistry evaluation of (i) the antioxidant capacity in the liver -by the determination of metallothioneins (MT) and superoxide dismutase (SOD) expression -as well as (ii) the possible induction of oxidative damage -by the determination of inducible nitric oxide synthase (iNOS), nitrotyrosine (NITT), malondialdehyde (MDA) and 8-oxoguanine (8-oxo) -that (iii) could increase apoptotic cell death -determined by cytochrome-c (cyto-c), caspase 1 (casp1) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Liver samples from Cu-supplemented (15 mg Cu sulphate/kg DM, n 5 5) and non-supplemented calves (n 5 5) that form part of other experiments to evaluate Cu status were collected at slaughter and processed for immunohistochemistry and TUNEL. MT expression was diffuse and SOD showed slight changes although without statistical significance. iNOS and NITT positive (1) cells significantly increased, mainly around the central veins in the animals from the Cu-supplemented group, whereas no differences were appreciated for the rest of the oxidative stress and apoptosis markers. Under the conditions of this study, which are the conditions of the cattle raised in intensive systems in NW Spain and also many European countries, routinely Cu supplementation increased the risk of the animals to undergo subclinical Cu toxicity, with no significant changes in the Cu storage capacity and the antioxidant defensive system evaluated by MT and SOD expression, but with a significant and important increase of oxidative damage measured by iNOS and NITT. The results of this study indicated that iNOS and NITT could be used as early markers of initial pathological changes in the liver caused by Cu supplementation in cattle, although more studies in cattle under different levels of Cu supplementation are needed.Keywords: cattle, copper, subclinical toxicity, oxidative stress, antioxidant defense ImplicationsThis study demonstrates an increased oxidative damage (measured by a significant increase of the markers inducible nitric oxide synthase (iNOS) and nitrotyrosine (NITT)) in the liver of intensively reared beef cattle receiving moderate copper (Cu) supplementation. This oxidative damage could be considered as the initial pathological change in the animal before further damage will occur, and thus, the markers iNOS and NITT could be used as early indicators of subclinical Cu toxicity in cattle under these nutritional conditions. IntroductionCopper (Cu) is an essential metal associated with several enzymes (either as a co-factor or as an allosteric component) that acts as an electron transfer intermediate in redox reactions (Uauy et al., 1998) therefore being vital for the normal function of the organisms. Cu in the liver is accumulated bound to metallothioneins (MT), proteins involved in the detox...

show abstract

“…Bharti et al (28) specified that cerebral epiphyseal proteins and melatonin activated and regulated hepatic and renal antioxidant mechanisms and increased GPx and SOD activity in the liver. In their study, Mauriz et al (29) indicated that melatonin added to potable water (20 mg/L) eliminated oxidative stress in the livers of elderly rats and contributed to the regulation of catalase and CuZn-SOD and GPx gene expressions.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical distribution of glutathione peroxidase and its gene expression via RT-PCR in the liver tissue of melatonin-administered mice

Taşçı¹,

Gülmez²

2014

Turk J Vet Anim Sci

View full text Add to dashboard Cite

The Early Miocene sandstone of the Burqan Formation from Midyan Basin is considered an oil-bearing unit. The outcrops of this sandstone, which are exposed in the northwestern part of the basin, have been studied through field and laboratory-based investigations. During the field work, 81 surface samples were collected for reservoir characterization. Laboratory analyses were undertaken to determine the effect of the diagenesis on the reservoir quality using integrated sedimentological, petrological, and petrophysical analyses. According to these analyses, the sandstone of Burqan Formation is predominately subarkosic and sublitharenite in nature, medium to course grained in size, rounded to subangular in shape, and poor to moderately sorted. Porosity of the studied sandstone, which is both syndepositional and diagenetic in origin, has been determined as poor to very high, with an average value of 22.73%. The observed permeability is moderate to very high, with an average estimate of 2444.2 millidarcy. Cementation coupled with compaction had an important effect on the porosity destruction after sedimentation and burial. The reservoir quality of the studied sandstone is reduced by clay minerals (kaolinite and smectite), calcite, and silica cementations, but, on other hand, it is increased by alteration and dissolution of the unstable grains, in addition to partial dissolution of calcite cements. The potential of the studied sandstone to serve as a reservoir is strongly related to sandstone diagenesis.

show abstract

RETRACTED: Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats

Cited by 74 publications

References 70 publications

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Histochemistry evaluation of the oxidative stress and the antioxidant status in Cu-supplemented cattle

Immunohistochemical distribution of glutathione peroxidase and its gene expression via RT-PCR in the liver tissue of melatonin-administered mice

Contact Info

Product

Resources

About