RETRACTED: Long noncoding RNA LINC00858 promotes osteosarcoma through regulating miR-139-CDK14 axis

Gu, Zenghui; Hou, Zhenhai; Zheng, Liqiang; Wang, Xinqiang; Wu, Liangbang; Zhang, Cheng

doi:10.1016/j.bbrc.2018.06.131

Cited by 33 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More and more LncRNAs have been confirmed to be involved in progression and development of OS . For example, Gu et al reported that LINC00858 significantly promoted OS cells' proliferation and invasion in vitro, and increased tumour growth in vivo through regulating miR‐139‐CDK14 axis . Xie et al reported that lncRNA TUG1 promoted cell proliferation and suppressed apoptosis in OS cells by regulating miR‐212‐3p/FOXA1 axis .…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206

Fei

Sui

Yang

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

The long intergenic non‐protein coding RNA regulator of reprogramming (lncRNA‐ROR) has been reported to play crucial regulatory roles in the pathogenesis and progression of multiple cancers. However, whether ROR is associated with the initiation and development of osteosarcoma (OS) remains unclear. Here, we found that ROR expression level was significantly up‐regulated in OS tissue samples compared to adjacent normal tissues, and the elevated ROR was closely correlated with advanced tumour‐node‐metastasis (TNM) stage and lymph node metastasis and poor overall survival rate. Functional assays showed that ROR knockdown suppressed the OS cell proliferation, colony formation, migration and invasion in vitro, and retarded tumour growth in vivo. In addition, miR‐206 was verified to be a target miRNA of ROR using bioinformatics online program and luciferase report assay. miR‐206 inhibition partially rescued the inhibitory effects on OS cells induced by ROR knockdown. In conclusion, these results suggested that ROR function as an oncogene in OS by sponging miR‐206 and might be a potential therapeutic target for patients with OS.

show abstract

Section: Discussionmentioning

confidence: 99%

RETRACTED: The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206

Fei

Sui

Yang

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Another study indicated that the expression level of LINC00858 in lung adenocarcinoma was 5.23 times that in normal lung tissues (22). Upregulated LINC00858 expression was also reported in osteosarcoma and knockdown of LINC00858 effectively inhibited osteosarcoma cell proliferation in vitro as well as tumor growth in vivo (9). The results of the present study also demonstrated abnormally upregulated LINC00858 expression in RB tissues and cells, which was similar to the results of these above previous studies.…”

Section: Discussionsupporting

confidence: 90%

“…LINC00858, a member of the lncRNA family with 2,685 nucleotides in length, was only recently begun to be investigated. Previous studies have indicated that LINC00858 has roles in several tumor types, including lung cancer (7), colorectal cancer (8) and osteosarcoma (9). To the best of our knowledge, LINC00858 has not been previously investigated in RB.…”

Section: Introductionmentioning

confidence: 93%

LINC00858 promotes retinoblastoma cell proliferation, migration and invasion by inhibiting miR‑3182

et al. 2019

View full text Add to dashboard Cite

The aim of the present study was to determine the role of long intergenic non-protein coding RNA 858 (LINC00858) in retinoblastoma (RB) and investigate the underlying molecular mechanisms. RB tissues and paracancerous tissues of 27 RB cases were obtained. RB cell lines (SO-RB50, Y79, HXO-RB44 and WERI-Rb1) and a normal retinal epithelial cell line (ARPE-19) were cultured for in vitro experiments. Batches of SO-RB50 and Y79 cells were assigned to groups transfected with small interfering RNA targeting LINC00858 (si-LINC00858 group), microRNA (miR)-3182 mimics or inhibitor, or the respective controls. A Cell Counting Kit-8 and Transwell assays were performed to assess the effect of the transfections on the proliferation, migration and invasion of SO-RB50 and Y79 cells. A luciferase reporter assay was performed using SO-RB50 cells to demonstrate the direct binding of LINC00858 and miR-3182. Reverse transcription-quantitative PCR was employed to detect LINC00858 and miR-3182 expression. Pearson correlation analysis was used to assess the correlation between the expression of LINC00858 and miR-3182. The results indicated that RB tissues and cells exhibited aberrantly elevated LINC00858 expression (P<0.05). Compared with those in the control-transfected group, SO-RB50 and Y79 cells of the si-LINC00858 group had a lower cell proliferation, as well as a lower number of migrated and invaded cells (all P<0.05). miR-3182 was proven to be a target gene of LINC00858, to be abnormally downregulated in RB tissues and cells (P<0.05) and to be negatively correlated with LINC00858 expression. Compared with those in the si-LINC00858 + inhibitor-negative control group, SO-RB50 and Y79 cells of the si-LINC00858 + miR-3182 inhibitor group exhibited a significantly higher relative proliferation, migration and invasion (all P<0.05). In conclusion, LINC00858 promoted RB cell proliferation, migration and invasion, at least partially by inhibiting miR-3182.

show abstract

“…For instance, Zhu et al reported that LINC00858 was highly expressed in non-small cell lung cancer and its forced expression promoted cell proliferation and induced cell migration and invasion by acting a molecular sponge for miR-422a [20]. Gu et al found that LINC00858 expression was up-regulated in osteosarcoma and its knockdown inhibits the proliferation and invasion of osteosarcoma cells through inhibiting CDK14 by up-regulating miR-139, suggesting the effect of LINC00858/miR-139/CDK14 axis on osteosarcoma tumorigenesis [19]. In addition, recent study by Yamada et al firstly reported that LINC00858 was a upregulated lncRNA in CRC [25].…”

Section: Discussionmentioning

confidence: 99%

“…LncRNA LINC00858 (LINC00858), a newly identified lncRNA, is locates in 10q23.1. Recently, the dysregulation of LINC00858 has been reported in two tumours, including osteosarcoma and lung cancer [19,20]. In addition, in these two tumours, LINC00858 played a positive regulator.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA LINC00858 promotes cells proliferation, migration and invasion by acting as a ceRNA of miR-22-3p in colorectal cancer

Sha¹,

Chen²,

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Though long non-coding RNA LINC00858 (LINC00858) has been shown to be involved in tumours of other tissues, its involvement in colorectal cancer (CRC) is still unknown. We aimed to investigated expression and mechanism LINC00858 in human CRC. In this study, we firstly found that LINC00858 expression was significantly up-regulated in both CRC tissues and cell lines by both online data and RT-PCR assay. Then, clinical assay revealed that high LINC00858 expression was significantly associated with advanced clinical progression and poor prognosis. Multivariate analysis demonstrated that high LINC00858 expression was an independent poor prognostic factor for CRC patients. Moreover, lost-offunction assay indicated that knockdown of LINC00858 suppressed CRC cells proliferation, migration and invasion, and promoted apoptosis. Mechanistically, bioinformatics analysis, dual-luciferase reporter assays, and western blot assays showed that LINC00858 functioned as competing endogenous RNA to repress miR-22-3p, which controlled its downstream target YWHAZ. Then, we suggested that LINC00858 exerted its function through the miR-22-3p/YWHAZ axis. To our knowledge, this is the first report which showed the role of LINC00858 in the progression of CRC. Our findings indicated that LINC00858 played an important role in CRC, and may serve as a novel prognostic factor and therapeutic target.

show abstract

RETRACTED: Long noncoding RNA LINC00858 promotes osteosarcoma through regulating miR-139-CDK14 axis

Cited by 33 publications

References 22 publications

RETRACTED: The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206

RETRACTED: The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206

LINC00858 promotes retinoblastoma cell proliferation, migration and invasion by inhibiting miR‑3182

Long non-coding RNA LINC00858 promotes cells proliferation, migration and invasion by acting as a ceRNA of miR-22-3p in colorectal cancer

Contact Info

Product

Resources

About