RETRACTED: The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206

Abstract

The long intergenic non‐protein coding RNA regulator of reprogramming (lncRNA‐ROR) has been reported to play crucial regulatory roles in the pathogenesis and progression of multiple cancers. However, whether ROR is associated with the initiation and development of osteosarcoma (OS) remains unclear. Here, we found that ROR expression level was significantly up‐regulated in OS tissue samples compared to adjacent normal tissues, and the elevated ROR was closely correlated with advanced tumour‐node‐metastasis (TNM) stage and lymph node metastasis and poor overall survival rate. Functional assays showed that ROR knockdown suppressed the OS cell proliferation, colony formation, migration and invasion in vitro, and retarded tumour growth in vivo. In addition, miR‐206 was verified to be a target miRNA of ROR using bioinformatics online program and luciferase report assay. miR‐206 inhibition partially rescued the inhibitory effects on OS cells induced by ROR knockdown. In conclusion, these results suggested that ROR function as an oncogene in OS by sponging miR‐206 and might be a potential therapeutic target for patients with OS.

lncRNA ROR promotes the progression of renal cell carcinoma through the miR‑206/VEGF axis

“…Consistent with the finding of the present study, previous studies reported impaired levels of miRNAs in various cancer types, including RCC (32–34). Furthermore, it was reported that ROR was able to induce the development of osteosarcoma by regulating miR-206 (43).…”

Long non‑coding RNA small nucleolar RNA host gene 1 knockdown suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating microRNA‑424‑5p/FGF2 in vitro

“…Several lncRNAs have been reported to be involved in the regulation of OS. For example, Fei et al (16) discovered that expression of the lncRNA regulator of reprogramming (ROR) is significantly increased in OS tissues and in OS cell lines, and that upregulation of ROR appears strongly related to tumour stage. Yang et al (23) found that the expression of lncRNA XIST is dramatically elevated in OS tissues and also strongly associated with tumour stage.…”

“…MicroRNAs (miRNAs) are a kind of small endogenous RNA that can influence the post-transcriptional regulation of specific genes (15). Increasing attention has been paid to the anti-tumoral roles of miRNAs in OS, such as miRNA (miR)-206 (16), miR-137 (9), and miR-193-3p (10). miR-424-5p is widely considered to be a suppressor in several types of human cancers, such as glioma (17), cholangiocarcinoma (18) and ovarian cancer (19).…”

Magic and mystery of microRNA‐32

“…Retinoblastoma is a highly malignant tumour that appears in retinal development and is the most common primary intraocular tumour in childhood and infancy 53 . Recent studies have shown that lncRNA‐ROR may contribute to the tumorigenesis and metastasis 54–56 . LncRNA‐ROR is significantly upregulated in retinoblastoma tissues, and its overexpression is significantly correlated with optic nerve invasion, nodal or distant metastasis, and recurrence.…”

“… 53 Recent studies have shown that lncRNA‐ROR may contribute to the tumorigenesis and metastasis. 54 , 55 , 56 LncRNA‐ROR is significantly upregulated in retinoblastoma tissues, and its overexpression is significantly correlated with optic nerve invasion, nodal or distant metastasis, and recurrence. LncRNA‐ROR modulates the EMT programme by competitively binding to endogenous miR‐32‐5p and regulating Notch signalling pathway activity in retinoblastoma cells; these behaviours may provide new insights into novel molecular therapeutic targets for retinoblastoma.…”