RETRACTED: Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2

Pan, Qiong; Niu, HuiYuan; Cheng, Longfei; Li, XiaoQiong; Zhang, QiGang; Ning, Ying

doi:10.1016/j.placenta.2017.03.008

Cited by 17 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both miR-346 and miR-582-3p targeted endocrine-gland-derived vascular endothelial growth factor (EG-VEGF) as well as matrix metalloproteinase 2 (MMP2) and MMP9, and strongly inhibited the migratory and invasive abilities of trophoblasts (Su et al 2017). Similarly, miR-93 (Pan et al 2017) and miR-204 (Yu et al 2015), which targeted MMP2 and MMP9, respectively, inhibit cell invasion. Members of the C19MC, miR-519d-3p (Ding et al 2015) and miR-520g (Jiang et al 2017a) also targeted MMP2 and inhibited migration and invasion, while miR-520c-3p inhibited invasion by suppressing CD44, which is needed for the interaction between EVTs and decidual extracellular matrix (Takahashi et al 2017).…”

Section: Mirnas In Trophoblast Differentiation Migration and Invasionmentioning

confidence: 99%

MicroRNAs: crucial regulators of placental development

Hayder¹,

O’Brien²,

Nadeem³

et al. 2018

Reproduction

119

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that are integral to a wide range of cellular processes mainly through the regulation of translation and mRNA stability of their target genes. The placenta is a transient organ that exists throughout gestation in mammals, facilitating nutrient and gas exchange and waste removal between the mother and the fetus. miRNAs are expressed in the placenta, and many studies have shown that miRNAs play an important role in regulating trophoblast differentiation, migration, invasion, proliferation, apoptosis, vasculogenesis/angiogenesis and cellular metabolism. In this review, we provide a brief overview of canonical and non-canonical pathways of miRNA biogenesis and mechanisms of miRNA actions. We highlight the current knowledge of the role of miRNAs in placental development. Finally, we point out several limitations of the current research and suggest future directions.

show abstract

Section: Mirnas In Trophoblast Differentiation Migration and Invasionmentioning

confidence: 99%

MicroRNAs: crucial regulators of placental development

Hayder¹,

O’Brien²,

Nadeem³

et al. 2018

Reproduction

119

View full text Add to dashboard Cite

show abstract

“…Through bioinformatics analysis, we selected miR‐204‐5p as a potential target of TUG1. Because the miR‐204 was upregulated in the placentas of PE patients, it was associated with trophoblast invasion . By luciferase reporter assay, we confirmed that miR‐204‐5p was a direct target of TUG1.…”

Section: Discussionmentioning

confidence: 57%

“…have identified 13 overexpressed miRNAs in PE patients compared to those in normal controls. Deregulation of miRNAs also reported to affect the migration and invasion of trophoblast cells . These results suggested that targeting regulation of miRNAs may provide new insights for the treatment of PE.…”

Section: Introductionmentioning

confidence: 73%

“…Previously, miR‐204‐5p was reported to participate in regulating cell proliferation, apoptosis and invasion by targeting different genes. In PE, our previous study also showed that miR‐204 suppressed trophoblast cell invasion by targeting MMP9 . MMP9, as one type of zinc‐dependent proteases, plays key roles in mediating cell invasion.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Long non‐coding RNA TUG1 regulates the migration and invasion of trophoblast‐like cells through sponging miR‐204‐5p

Wang

Gao

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Preeclampsia (PE) is a leading cause of maternal and perinatal death. Accumulated evidence suggests that many long non-coding RNAs (lncRNAs) are abnormally expressed in placentas from PE patients, and they may play functional roles in the development of PE. The present study aimed to investigate the functional role TUG1 in PE and explore the potential molecular mechanisms. Clinically, the expression of TUG1 in placental tissues from PE and normal controls was determined. In vitro, human trophoblast HTR-8/SVneo and JAR cells were employed for loss or gain-offunction assays. Our results demonstrate that TUG1 was downregulated in PE placental tissues compared with normal controls. Moreover, downregulation of TUG1 inhibited the migration and invasion of trophoblast-like cells. Bioinformatics analysisand functional assays showed that TUG1 interacted with miR-204-5p and negatively regulated the expression and function of miR-204-5p in trophoblast cells.Furthermore, TUG1-mediated migration and invasion of trophoblast cells was regulated by miR-204-5p. Together, our results suggested that TUG1 regulates trophoblast migration and invasion partly through sponging miR-204-5p, and the TUG1/ miR-204-5p axis could be a potential therapeutic target for the treatment of PE. K E Y W O R D Sinvasion, lncRNA TUG1, miR-204-5p, MMP9, preeclampsia, trophoblast

show abstract

“…Una de las teorías más aceptadas para la presentación de complicaciones hipertensivas en el embarazo, es la implantación insuficiente de las células del citotrofoblasto, que se infiltran en la porción decidual de las arterias espirales, pero no penetran en su segmento miometrial (14,15). Las arterias espirales, por lo tanto, no se transforman en canales vasculares de gran capacitancia, sino que se mantienen estrechas, lo que resulta en una disminución en el flujo placentario (16)(17)(18). y da como resultado una alta velocidad de perfusión en el espacio intervelloso, lo que genera estrés de cizallamiento en el trofoblasto (19,20).…”

Section: Fisiopatologíaunclassified

Características clínicas y fisiológicas del síndrome de Hellp

et al. 2018

View full text Add to dashboard Cite

RESUMENEl síndrome de HELLP es una complicación multisistémica del embarazo que se distingue por el trastorno hipertensivo más la triada: hemólisis microangiopática, elevación de enzimas hepáticas y disminución del conteo de plaquetas. Está asociado con la aparición de graves complicaciones perinatales e incremento de la mortalidad materna. Ocurre en 0,5 a 0,9% de todos los embarazos y en 10 a 20% de las pacientes con preeclampsia-eclampsia. Complicaciones obstétricas como ésta deben sospecharse de manera temprana para poderlas atender de manera oportuna y así prevenir situaciones potencialmente fatales tanto para la madre como para el feto. Es por ello, que deben integrarse adecuadamente los signos y síntomas, comprendiendo el reto diagnóstico que este síndrome puede significar.ABSTRACT HELLP syndrome is a severe systemic complication in pregnancy characterized by hypertensive disorder added to the clinical profile that includes: microangiopathic hemolysis, elevation of liver enzymes, and decreased platelet count. It is associated with the appearance of serious perinatal complications and increased maternal mortality. It occurs in 0.5 to 0.9% of all pregnancies and in 10 to 20% of patients with pre-eclampsia/eclampsia. Obstetric complications such as this syndrome need to be suspected in clinical practice, to prevent fatal outcomes for both, the mother and the fetus. Therefore, clinical manifestations should be identified early to approach challenges that the diagnosis may pose.

show abstract

RETRACTED: Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2

Cited by 17 publications

References 30 publications

MicroRNAs: crucial regulators of placental development

MicroRNAs: crucial regulators of placental development

Long non‐coding RNA TUG1 regulates the migration and invasion of trophoblast‐like cells through sponging miR‐204‐5p

Características clínicas y fisiológicas del síndrome de Hellp

Contact Info

Product

Resources

About