RETRACTED: Increased Risk of Stomach and Esophageal Malignancies in People With AIDS

Abstract

BACKGROUND & AIMS People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hodgkin lymphomas (NHLs) of the stomach and esophagus in people with acquired immunodeficiency syndrome (AIDS). METHODS We analyzed data from the HIV/AIDS Cancer Match Study, which links data collected from 1980 to 2007 for 16 US population-based HIV and AIDS and cancer registries. We compared risks of stomach and esophageal malignancies in people with AIDS (N = 596,955) with those of the general population using standardized incidence ratios (SIRs). We assessed calendar trends using Poisson regression. RESULTS People with AIDS had increased risks of carcinomas of the esophagus (SIR, 1.69; 95% confidence interval [CI], 1.37–2.07; n = 95) and stomach (SIR, 1.44; 95% CI, 1.17–1.76; n = 96). Risk was increased for esophageal adenocarcinoma (SIR, 1.91; 95% CI, 1.31–2.70) and squamous cell carcinoma (SIR, 1.47; 95% CI, 1.10 –1.92). People with AIDS had greater risks of carcinomas of the gastric cardia (SIR, 1.36; 95% CI, 0.83–2.11) and noncardia (SIR, 1.53; 95% CI, 1.12–2.05) than the general population. Although most stomach and esophageal NHLs that developed in people with AIDS were diffuse large B-cell lymphomas, these individuals also had an increased risk of stomach mucosa–associated lymphoid tissue lymphoma (SIR, 5.99; 95% CI, 3.19 –10.2; n = 13). The incidence of carcinomas remained fairly constant over time, but rates of NHL decreased from 1980 to 2007 (Ptrend < .0001). CONCLUSIONS People with AIDS are at increased risk for developing esophageal and stomach carcinomas and NHLs. Although the incidence of NHL decreased from 1980 to 2007 as treatments for HIV infection improved, HIV-infected individuals face continued risks of esophageal and stomach carcinomas.

Infecção VIH e Neoplasias Não Definidoras de SIDA: Experiência de um Centro

“…2,32,33 De particular interesse são os dois casos de neoplasia, com desfecho fatal, em ambas as doentes infectadas por VIH-2. O primeiro refere-se a um caso de uma neoplasia da conjuntiva, também estreitamente relacionada com a Fevereiro MC.…”

HIV-Associated Gastrointestinal Cancer

“…Identified risk factors were moderate immunosuppression, smoking and alcohol use. A study from 2012 initially classified the risk of developing esophageal and gastric carcinoma as elevated in HIV-positive patients [13]. However, this was retracted in 2016 due to incorrect application of statistics [14].…”

“…However, H.p. infection is less prevalent in HIV-positive patients, especially in the case of manifest immunosuppression [13]. Consequently, only smoking remains as a risk factor, but this item has not been investigated in the HIV population with gastric malignancy.…”

Somatic and gynecologic anamnesis in HIV-infected patients in ART programms

“…Эти данные согласуются с мнением других авторов [16,17], по результатам которых частота развития пато-логии щитовидной железы достоверно выше у жен-щин, длительно находящихся на ВААРТ.…”