Retracted: Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial

Asemi, Zatollah; Hashemi, Teibeh; Karamali, Maryam; Samimi, Mansooreh; Esmaillzadeh, Ahmad

doi:10.3945/ajcn.113.072785

Cited by 188 publications

(194 citation statements)

References 45 publications

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“…Vitamin D and calcium may increase the oxidation of whole body fat and increase lipolysis [27,28] . The present investigation found an increase in free fatty acids in blood at d 84 and 112, thus suggesting increased breakdown of lipids after administration of vitamin D. In the current study, a decrease in total cholesterol at d 84 and 112 was observed, consistently with previous findings that after two doses of 50 000 IU vitamin D3, there is a reduction in the concentration of serum total cholesterol in women with gestational diabetes mellitus [29] . Therefore, randomized controlled trials with larger sample sizes are necessary to elucidate the effects of vitamin D on blood lipids and the potential benefits for obesity and the prevention of cardiovascular diseases.…”

Section: Discussionsupporting

confidence: 80%

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Chen

Duan

et al. 2016

Acta Pharmacol Sin

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Aim: To examine the biological consequences and demographic factors that might affect the pharmacokinetics of vitamin D3 after a single high dose intervention in a young Chinese population with vitamin D insufficiency status. Methods: A total of 28 young subjects (25 to 35 years old) with vitamin D insufficiency status [serum 25(OH)D <30 ng/mL] was recruited in Shanghai, China. The subjects were orally administered a single high dose of vitamin D3 (300 000 IU). Baseline characteristics and blood samples were collected at d 0, 1, 2, 3, 7, 28, 56, 84 and 112 after the intervention. The blood biomarker levels were determined with standardized methods. Results: The intervention markedly increased the blood 25(OH)D3 levels within the first five days (mean T max =5.1±2.1 d) and sustained an optimal circulating level of 25(OH)D3 (≥30 ng/mL) for 56 d. After the intervention, body weight and baseline 25(OH)D3 levels were significantly correlated with circulating 25(OH)D3 levels. No adverse events and no consistently significant changes in serum calcium, creatinine, glucose, parathyroid hormone, vitamin D binding protein, or the urinary calcium/creatinine ratio were observed. However, there was a significant increase in phosphorus after the vitamin D3 intervention. Total cholesterol and triglyceride levels were decreased at the end of the trial. Conclusion: The pharmacokinetics of vitamin D after intervention were influenced by baseline 25(OH)D3 levels and the body weight of the subjects. The results suggest that a single high oral vitamin D3 intervention is safe and efficient for improving the vitamin D status of young Chinese people with vitamin D insufficiency.

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Section: Discussionsupporting

confidence: 80%

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Chen

Duan

et al. 2016

Acta Pharmacol Sin

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“…Epidemiological data have indicated that pregnant women with GDM were more likely to be vitamin D deficient [12]. In our previous study, we found improved metabolic profiles among pregnant women with GDM following the consumption of 100 000 IU vitamin D supplements for 6 weeks [13]. Others have also reported the beneficial effects of vitamin D supplementation on metabolic status of GDM patients [14].…”

Section: Endocrine Carementioning

confidence: 65%

Favorable Effects of Vitamin D Supplementation on Pregnancy Outcomes in Gestational Diabetes: A Double Blind Randomized Controlled Clinical Trial

2014

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during pregnancy ranges from 1-14 % of all pregnancies depending on the population studied and the diagnostic tests used [2]. The prevalence of this condition is 4.7 % among Iranian pregnant women [3]. GDM is associated with short-term and long-term adverse health outcomes for both mothers and offspring [4]. Infants of diabetic mothers are at risk for physiologic, metabolic, and congenital complications such as preterm birth, macrosomia, asphyxia, respiratory distress, hypoglycemia, hypocalcemia, hyperbilirubinemia, polycythemia and hyperviscosity, hypertrophic cardiomyopathy as well as congenital anomalies, particularly of the central nervous system [5]. Women with GDM have higher rates of Cesarean section (CS) [6], are at increased risk of pregnancy-associated hypertension [7] and increased risk of perinatal morbidity and type 2 diabetes in later life [5,8].

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“…Medical nutrition therapy, including use of a lowglycaemic-index diet and the Dietary Approaches to Stop Hypertension (DASH) eating plan (6) , have been suggested for prevention and management of GDM (7) . Beyond lifestyle interventions, Ca or vitamin D supplementation has also been proposed as an approach that could improve pregnancy outcomes in GDM patients (8,9) . Previous studies have shown that circulating Ca and vitamin D levels are strongly associated with fasting insulin and post-challenge glucose concentrations, GDM and pregnancy outcomes (10,11) .…”

mentioning

confidence: 99%

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Karamali

Asemi

Ahmadi-Dastjerdi

et al. 2015

Public Health Nutr.

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Objective: The present study was designed to assess the effects of Ca + vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM). Design: A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca + vitamin D supplements or placebo. Individuals in the Ca + vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D 3 ) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined. Setting: A urban community setting in Arak, Iran. Subjects: Sixty women with GDM and their newborns, living in Arak, Iran were enrolled. Results: Women treated with Ca + vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P = 0·002) and maternal hospitalization (0 v. 13·3 %, P = 0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca + vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P = 0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P = 0·03) and hospitalization (20·0 % v. 56·7 %, P = 0·03) were also seen in the supplemented group of newborns than in the placebo group. Conclusions: Ca + vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

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Retracted: Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial

Abstract: Vitamin D supplementation in pregnant women with GDM had beneficial effects on glycemia and total and LDL-cholesterol concentrations but did not affect inflammation and oxidative stress. This trial was registered at www.irct.ir as IRCT201305115623N7.

Cited by 188 publications

References 45 publications

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Favorable Effects of Vitamin D Supplementation on Pregnancy Outcomes in Gestational Diabetes: A Double Blind Randomized Controlled Clinical Trial

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

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