RETRACTED: Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells

Liu, Yan; Bi, Tingting; Dai, Wei; Wang, Gang; Qian, Liqiang; Gao, Quangen; Shen, Genhai

doi:10.1177/1533034615587616

Cited by 24 publications

(20 citation statements)

References 30 publications

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“…Liu et al discovered that OM inhibited the proliferation and induced apoptosis of Hep‐G2 and SMMC‐7721 human hepatocellular carcinoma cells. Meanwhile, the expression levels of Bax and caspase‐3 were significantly up‐regulated, whereas the expression of Bcl‐2 was down‐regulated by OM in a dose‐dependent manner (Liu et al , ). Wu et al found that OM could inhibit prostate cancer cells by decreasing the expression of p53 and Bcl‐2 and increasing the expression of Bax in a dose‐dependent manner (Wu et al , ).…”

Section: Introductionmentioning

confidence: 99%

Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine

2016

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Oxymatrine, an alkaloid component extracted from the roots of Sophora species, has been shown to have antiinflammatory, antifibrosis, and antitumor effects and the ability to protect against myocardial damage, etc. The potential signaling pathways involved in the clinical application of oxymatrine might include the TGF-β/Smad, toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells, toll-like receptor9/TRAF6, Janus kinase/signal transduction and activator of transcription, phosphatidylinositol-3 kinase/Akt, delta-opioid receptor-arrestinl-Bcl-2, CD40, epidermal growth factor receptor, nuclear factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathways, and dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine metabolism pathway. In this review, we summarize the recent investigations of the signaling pathways related to oxymatrine to provide clues and references for further studies on its clinical application. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine

2016

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“…[11][12][13] Furthermore, it has been demonstrated that oxymatrine exerts anti-tumor properties in several cancers via different signaling pathways, such as suppression of proliferation and promotion of apoptosis. [14][15][16][17] Although previous studies showed that oxymatrine mediates Bax and Bcl-2 expression in the human breast cancer MCF-7 cell-line, the pharmacological property and underlying mechanism of action of oxymatrine against breast cancer cells remains largely unknown. 18) In the present study, we demonstrated the anti-tumor effects of oxymatrine against the breast cancer cell-lines, MCF-7 and MDA-MB-231, and investigated potential molecular mechanisms which might mediate the anti-neoplastic activity of oxymatrine.…”

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confidence: 99%

Oxymatrine Promotes S-Phase Arrest and Inhibits Cell Proliferation of Human Breast Cancer Cells <i>in Vitro</i> through Mitochondria-Mediated Apoptosis

Cai

et al. 2017

Biological & Pharmaceutical Bulletin

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Breast cancer is one of the most lethal malignancies in the world. Oxymatrine is the major effective and toxic alkaloid component which is derived from the root of Sophora flavescens AIT, a traditional Chinese medicine which is widely distributed in Asia and the Pacific Islands. In the current research study, we investigated the effects and mechanisms of action of oxymatrine on breast cancer cells. We demonstrated that the viability and single cell proliferation capability of MCF-7 and MDA-MB-231, two breast cancer cell lines which are widely used in in vitro study, were significantly suppressed in a time-and concentration-dependent manner. Furthermore, the cell cycle of breast cancer cells treated with oxymatrine was arrested at the Sphase of the cell cycle. Oxymatrine also triggered apoptosis in breast cancer cells by modulating apoptosisrelated proteins, such as cleaved Caspase-3, cleaved Caspase-9 and poly(ADP-ribose) polymerase (PARP). The remarkable reduction in the ratio of Bcl-2/Bax was also observed in oxymatrine treated breast cancer cells.In conclusion, our research demonstrated that oxymatrine plays a critical role in suppressing carcinogenesis of breast cancer cells through cell cycle arrest and induction of mitochondria-mediated apoptosis, which suggests a promising application of this drug in breast cancer therapy.Key words oxymatrine; apoptosis; breast cancer; cell cycle Breast cancer is the most highly prevalent and diagnosed carcinoma in women worldwide and is the leading cause of cancer deaths in women, with approximately 500000 newly diagnosed cases reported in 2012.1) Currently, the main treatment options for breast cancer cases include surgery, radiotherapy, chemotherapy, hormone and immunological therapy. Although effectiveness could be observed in breast cancer patients receiving a variety of therapies, the high toxicity of these treatments to normal tissues is practically inevitable. Furthermore, breast cancer cells often propagate distant metastases and multi-drug resistance, which represents a main cause for treatment failure in cancer patients.2-4) Thus, the search for novel effective therapies and targeted drugs are an urgent priority with the aim of improving the efficacy of breast cancer treatment.Traditional Chinese medicine has been shown to be a fertile source of novel drug discovery. Many active components which are extracted from traditional Chinese herbs exhibit effects in many human diseases.5-7) For example, oxymatrine is the main effective and toxic alkaloid component derived from the root of Sophora flavescens AIT, which is widely distributed in Asia and the Pacific Islands.8-10) It was previously reported that oxymatrine displays specific pharmacological effects in targeting hepatitis B infections and liver fibrosis. [11][12][13] Furthermore, it has been demonstrated that oxymatrine exerts anti-tumor properties in several cancers via different signaling pathways, such as suppression of proliferation and promotion of apoptosis. [14][15][16][17] Although previous studies s...

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“…Although the antitumor activities of OMT have been observed in various tumors181920212223243839, there are no reports regarding the effects of OMT on human synovial sarcoma. In this study, we found that OMT inhibited the viability of SW982 cells in a time- and dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that OMT exhibits a variety of pharmacological effects, including antiinflammatory11, anti-allergic12, anti-viral13, antifibrotic14, cardioprotective15, anti-arrhythmic16, analgesic17 and angiogenic effects18. More importantly, recent evidence indicates that OMT plays an important role in the treatment of various tumors, such as hepatocellular carcinoma19, gastric cancer20, colon cancer21, pancreatic cancer18, osteosarcoma22, prostate cancer23 and breast cancer24. However, to the best of our knowledge, there are no reports regarding the antitumor activities of OMT in human synovial sarcoma.…”

mentioning

confidence: 99%

HMGB1-mediated autophagy decreases sensitivity to oxymatrine in SW982 human synovial sarcoma cells

Cai

Liu

et al. 2016

Sci Rep

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Oxymatrine (OMT) is a type of alkaloid extracted from a traditional Chinese medicinal herb, Sophora flavescens. Although the antitumor activities of OMT have been observed in various cancers, there are no reports regarding the effects of OMT on human synovial sarcoma. In the present study, we analyzed the antitumor activities of OMT in SW982 human synovial sarcoma cells and determine whether high mobility group box protein 1 (HMGB1)-mediated autophagy was associated with its therapeutic effects. We found that OMT exhibited antitumor activity in SW982 cells and facilitated increases in autophagy. Inhibition of autophagy by 3-MA or ATG7 siRNA increased the level of apoptosis, which indicated that OMT-induced autophagy protected cells from the cytotoxicity of OMT. Administration of OMT to SW982 cells increased the expression of HMGB1. When HMGB1 was inhibited via HMGB1-siRNA, OMT-induced autophagy was decreased, and apoptosis was increased. Furthermore, we found that HMGB1-siRNA significantly increased the expression of p-Akt and p-mTOR. OMT-induced autophagy may be mediated by the Akt/mTOR pathway, and HMGB1 plays a vital role in the regulation of autophagy. Therefore, we believe that combining OMT with an inhibitor of autophagy or HMGB1 may make OMT more effective in the treatment of human synovial sarcoma.

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RETRACTED: Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells

Cited by 24 publications

References 30 publications

Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine

Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine

Oxymatrine Promotes S-Phase Arrest and Inhibits Cell Proliferation of Human Breast Cancer Cells <i>in Vitro</i> through Mitochondria-Mediated Apoptosis

HMGB1-mediated autophagy decreases sensitivity to oxymatrine in SW982 human synovial sarcoma cells

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