Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine

Abstract

Oxymatrine, an alkaloid component extracted from the roots of Sophora species, has been shown to have antiinflammatory, antifibrosis, and antitumor effects and the ability to protect against myocardial damage, etc. The potential signaling pathways involved in the clinical application of oxymatrine might include the TGF-β/Smad, toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells, toll-like receptor9/TRAF6, Janus kinase/signal transduction and activator of transcription, phosphatidylinositol-3 kinase/Akt, delta-opioid receptor-arrestinl-Bcl-2, CD40, epidermal growth factor receptor, nuclear factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathways, and dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine metabolism pathway. In this review, we summarize the recent investigations of the signaling pathways related to oxymatrine to provide clues and references for further studies on its clinical application. Copyright © 2016 John Wiley & Sons, Ltd.

Gastroprotective and anti‐ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival mechanisms

“…Oxymatrine (OXY, Figure 1) is a quinolizidine alkaloid derived from Radix Sophora flavescens, and it possesses significant antioxidative and antiinflammatory activities via regulating several related signaling pathways (Liao et al, 2016;Lu, Xiang, & Xia, 2016;Ozturk, Cetinkaya, Yilmaz, & Ozturk, 2017;Zheng, Niu, Liu, Shi, & Lu, 2005). In the present study, we suspected that OXY has beneficial effects on gastric ulcers.…”

“…The use of medicinal plants or their derived active constituents that exhibit anti‐ulcer effects may be an alternative choice for the treatment of peptic ulcer disease in patients. Oxymatrine (OXY, Figure ) is a quinolizidine alkaloid derived from Radix Sophora flavescens , and it possesses significant antioxidative and antiinflammatory activities via regulating several related signaling pathways (Liao et al, ; Lu, Xiang, & Xia, ; Ozturk, Cetinkaya, Yilmaz, & Ozturk, ; Zheng, Niu, Liu, Shi, & Lu, ). In the present study, we suspected that OXY has beneficial effects on gastric ulcers.…”

<p>Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway</p>

“…Its molecular formula is C 5 H 24 N 2 O 2 , and it is a hydrophilic monomer. 3 Some research has shown that oxymatrine has anti-tumor effects in breast cancer, non-small-cell lung cancer, cervical cancer, and bladder cancer cells. [4][5][6][7] Oxymatrine can inhibit the proliferation and migration of tumor cells by inhibiting the p38, EGFR/ PI3K/AKT/mTOR, and MEK-1/ERK1/2/MMP2 signaling pathways.…”

Oxymatrine suppresses MOVAS proliferation induced by platelet-derived growth factor via G0/G1 arrest

“…Oxymatrine (OMT), one of the main bioactive ingredients of Sophorae flavescentis radix, which is known as a traditional Chinese herbal medicine extracted from the dried root of Sophorae flavescens Aiton [14,15]. Previous studies have demonstrated that OMT shows a wide-range of pharmacological effects, including anti-inflammatory, anticancer, antiviral and immunomodulatory effects [14,[16][17][18][19].…”

“…Previous studies have demonstrated that OMT shows a wide-range of pharmacological effects, including anti-inflammatory, anticancer, antiviral and immunomodulatory effects [14,[16][17][18][19]. In recent years, the cardio-protective effects of OMT are becoming more and more arresting, and it has been used to treat cardiovascular diseases via anti-arrhythmic effect, vasodilative activity, hypolipidemic, positive inotropic effect and resistance of ventricular remodeling [20][21][22][23][24][25].…”