RETRACTED: Comparison of two aprotinin dosage regimens in pediatric patients having cardiac operations

Boldt, Joachim; Knothe, Christoph; Zickmann, B.; Wege, Niels; Dapper, F.; Hempelmann, G.

doi:10.1016/s0022-5223(19)34197-2

Cited by 74 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, a diminished expression of 2 -adrenoceptors on platelet membranes is included among the platelet abnormalities observed during extracorporeal circulation [118] and it is considered responsible for unpaired haemostasis [119,120].…”

Section: Platelet Catecholamine Receptorsmentioning

confidence: 99%

Role of catecholamines in platelet function: pathophysiological and clinical significance

Anfossi

Trovati

1996

Eur J Clin Investigation

165

107

View full text Add to dashboard Cite

Platelets are involved in the pathogenesis of vascular damage in both atherosclerosis and arterial hypertension. Their reactivity in vivo is influenced by different factors, including sympathoadrenal activation, plasma levels of atherogenic lipoproteins and haemorrheological changes. In the present review, we examine the modulation of platelet function by the sympathoadrenal system and concentrate on the role of circulating catecholamines in the control of platelet responses. Human platelets exhibit both adrenergic and dopaminergic receptors that are influenced by different catecholamines. alpha(2)-Adrenoceptors of alpha(2A) subtype prevail on platelet membrane; through their stimulation, catecholamines potentiate the effects of other agonists and, at higher concentrations, initiate platelet responses, including aggregation, secretion and arachidonate pathway activation. Physiological and pathological conditions causing sympathoadrenal activation in vivo, i.e. physical activity, mental stress, insulin-induced hypoglycaemia, acute coronary ischaemia and heart failure, modify the circulating platelet populations and modulate platelet reactivity through an increase in circulating catecholamines. A sympathoadrenal hyperactivation modifies the function of circulating platelets through direct catecholamine effects, catecholamine-induced changes of haemodynamic factors and lipid pattern and inhibition of the vascular eicosanoid synthesis. The catecholamine effects on platelet function can be involved in the interplay among stress, adrenomedullary system activation and cardiovascular diseases.

show abstract

Section: Platelet Catecholamine Receptorsmentioning

confidence: 99%

Role of catecholamines in platelet function: pathophysiological and clinical significance

Anfossi

Trovati

1996

Eur J Clin Investigation

165

107

View full text Add to dashboard Cite

show abstract

“…However, many pediatric dosing regimens do not achieve these levels and despite aprotinin being used in many different centers world wide there is no consensus on the correct dose (40,41). Some studies have shown no benefit from the use of aprotinin in children, while others have shown a benefit (40,(42)(43)(44)(45). Mossinger et al (44) in a prospective, double blind, randomized, placebo controlled study, investigated the effect of aprotinin in 60 patients weighing less than 10 kg undergoing cardiac surgery.…”

Section: Antifibrinolytics Aprotininmentioning

confidence: 99%

Aspects of bleeding after cardiac surgery in children

McEwan

2007

Pediatric Anesthesia

View full text Add to dashboard Cite

“…Aprotinin also has been used for patients undergoing liver transplantations and for patients experiencing acute hemorrhage 5 . There are ongoing studies to determine the efficacy and safety of administering aprotinin to pediatric patients 6 …”

Section: Therapeutic Use Of Aprotininmentioning

confidence: 99%

The use of aprotinin for patients undergoing coronary artery bypass graft procedures

Whitener

Doyal²

1996

AORN Journal

View full text Add to dashboard Cite

RETRACTED: Comparison of two aprotinin dosage regimens in pediatric patients having cardiac operations

Cited by 74 publications

References 25 publications

Role of catecholamines in platelet function: pathophysiological and clinical significance

Role of catecholamines in platelet function: pathophysiological and clinical significance

Aspects of bleeding after cardiac surgery in children

The use of aprotinin for patients undergoing coronary artery bypass graft procedures

Contact Info

Product

Resources

About