Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

Zhang, Nanyang; Zhang, Xianxiang; Xu, Wenjian; Zhang, Xiaoxiao; Mu, Zepeng

doi:10.1111/nyas.14679

Cited by 20 publications

(11 citation statements)

References 32 publications

(61 reference statements)

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“…Therefore, circRNAs released from brain and nerve tissue lesions can be detected in peripheral blood, potentially serving as a novel biomarker to assist in the diagnosis of PD. More interestingly, increasing evidence has shown that circRNAs can act as molecular sponges of microRNAs (miRNAs) through the competing endogenous RNA (ceRNA) mechanism and competitively bind to miRNAs to alleviate miRNA inhibition [ [11] , [12] , [13] ]. Therefore, further exploration of the molecular mechanism of circRNA involvement in PD is conducive to better understanding the pathogenesis of PD and developing therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

Cheng

Wang

et al. 2022

Redox Biology

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Section: Introductionmentioning

confidence: 99%

CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

Cheng

Wang

et al. 2022

Redox Biology

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“…Related research found that circ0000069 promotes the proliferation, invasion, and migration of CRC cells and was associated with age, lymph node metastasis, and TNM staging in patients with CRC [ 20 ]. He et al found that circRNA_103948 regulates the autophagy of colorectal cancer cells through the miR-1236-3p/TPT1 axis and affects the progression of CRC [ 21 ]. In addition, studies have found that Circ-GALNT16 inhibits the progression of CRC by regulating the sequence-specific DNA binding capacity of the hnRNPK-p53 transcription complex mediated by SENP2 to inhibit Serpine1 expression [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway

et al. 2022

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Background Circular RNAs (circRNAs) have emerged as vital regulators of the initiation and progression of diverse kinds of human cancers. In this study, we explored the role of hsa_circ_0000231 and its downstream pathway in CRC. Methods The expression profile of circRNAs in 5 pairs of CRC tissues and adjacent normal tissues were analyzed by Microarray. Quantitative real-time PCR and in situ hybridization and Base Scope Assay were used to determine the level and prognostic values of hsa_circ_0000231. Then, functional experiments in vitro and in vivo were performed to investigate the effects of hsa_circ_0000231 on cell proliferation. Mechanistically, fluorescent in situ hybridization, dual luciferase reporter assay, RNA pull-down and RNA immunoprecipitation experiments were performed to confirm the interaction between hsa_circ_0000231 and IGF2BP3 or has_miR-375. Results We acquired data through circRNA microarray profiles, showing that the expression of hsa_circ_0000231 was upregulated in CRC primary tissues compared to adjacent normal tissues, which was indicated poor prognosis of patients with CRC. Functional analysis indicated that inhibition of hsa_circ_0000231 in CRC cell lines could suppress CRC cell proliferation as well as tumorigenesis in vitro and in vivo. The mechanistic analysis showed that hsa_circ_0000231 might, on the one hand, act as a competing endogenous RNA of miR-375 to promote cyclin D2 (CCND2) and, on the other hand, bind to the IGF2BP3 protein to prevent CCND2 degradation. Conclusions The findings suggested that hsa_circ_0000231 facilitated CRC progression by sponging miR-375 or binding to IGF2BP3 to modulate CCND2, implying that hsa_circ_0000231 might be a potential new diagnostic and therapeutic biomarker of CRC.

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“…After discarding crystal violet staining solution, cells were washed with distilled water. The colony number in each well was determined using an inverted microscope at × 40 magnification (Zeiss, Oberkochen, Germany) [ 21 ].…”

Section: Colony Formation Assaysmentioning

confidence: 99%

CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis

Lin

Liu

et al. 2022

Bioengineered

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Recent studies have shown that circRNAs can act as oncogenic factors or tumor suppressors by sponging microRNAs (miRNAs). The upregulation of circ_0023984 was reported in esophageal squamous cell carcinoma (ESCC). However, its functional role in ESCC remain unclear. In the present study, circ_0023984 expression in ESCC cells and tissues were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting (WB). Subcellular fraction experiment was performed to determine relative nuclear-cytoplasmic localization. The loss-of-function effects of circ_0023984 in ESCC cell lines were investigated by shRNA-mediated knockdown. Functional assays including cell Counting Kit-8 (CCK-8), 5-Ethynyl-2’-deoxyuridine (EDU) incorporation, colony formation and Transwell migration assays were conducted to assess the malignant phenotype. The interaction between the two molecules was analyzed by RNA pull-down, luciferase reporter assay and RNA immunoprecipitation (RIP). The subcutaneous tumor model in nude mice was used to assess the role of circ-0023984 in tumorigenesis. We found that ESCC patients with high circ_0023984 expression was associated with a poor prognosis. The knockdown of circ_0023984 suppressed cell growth, invasion, and migration in ESCC cells. Circ_0023984 interacted with miR-134-5p and inhibited its activity, which promoted the expression of CST4 (Cystatin-S). Circ_0023984 also regulated tumorigenesis in a CST4-dependent manner. Together, our study indicates that the oncogenic role of Circ_0023984 is mediated by miR-134-5p/CST4 Axis in ESCC, which could serve as potential targets for future therapeutic strategies.

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Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

Cited by 20 publications

References 32 publications

CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway

CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis

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