Retracted: Characterization of enhanced antibacterial effects of novel silver nanoparticles

Abstract

In the present study, we report the preparation of silver nanoparticles in the range of 10–15 nm with increased stability and enhanced anti-bacterial potency. The morphology of the nanoparticles was characterized by transmission electron microscopy. The antibacterial effect of silver nanoparticles used in this study was found to be far more potent than that described in the earlier reports. This effect was dose dependent and was more pronounced against gram-negative bacteria than gram-positive organisms. Although bacterial cell lysis could be one of the reasons for the observed antibacterial property, nanoparticles also modulated the phosphotyrosine profile of putative bacterial peptides, which could thus affect bacterial signal transduction and inhibit the growth of the organisms.

Catharanthus roseus: a natural source for the synthesis of silver nanoparticles

“…Lee et al [29] investigated the antibacterial effect of nanosized silver colloidal solution against Staphylococcus aureus (S. aureus) and Klebsiella pneumoniae after padding the solution on textile fabrics. Shrivastava et al [30] studied antibacterial activity against Escherichia coli (E. coli) (ampicillin resistant), E. coli, S. aureus, and Salmonella typhi (multi-drug resistant). They reported that the effect was dose dependent and was more pronounced against gram-negative organisms than gram-positive ones.…”

“…They reported that the effect was dose dependent and was more pronounced against gram-negative organisms than gram-positive ones. They found that the major mechanism through which silver nanoparticles manifest antibacterial properties was either by anchoring or penetrating the bacterial cell wall, and modulating cellular signaling by dephosphorylating putative key peptide substrates on tyrosine residues [30] . The antibacterial efficacy of the biogenic silver nanoparticles reported in the present study may be ascribed to the mechanism described above but it still remains to clarify the exact effect of the nanoparticles on important cellular metabolism like DNA, RNA and protein synthesis.…”

Pharmacological Assessment, Green synthesis and Characterization of Silver Nanoparticles of Sonneratia apetala Buch.-Ham. Leaves

“…Nanoparticles may alter the phosphotyrosine profile of bacterial peptides and dephosphorylation is realized in the tyrosine residues of Gram -ve bacteria. It was reported that the nanoparticles dephosphorylate the peptide substrates of tyrosine residues, leading to signal transduction inhibition and thus the termination of growth (Shrivastava et al, 2007). The variation in the level of antibacterial activity between Gram +ve and Gram -ve bacteria in this study may be the outcome of the arrangement pattern of cell wall components.…”

Silver Nano Particles Prevent Platelet Adhesion on Immobilized Fibrinogen

“…The size of these particles can be suitably manipulated to enable them to pass through biological membranes and affect cell physiology [16], which has been a challenge for the traditional medicines. Stable silver nanoparticles have been synthesized in the lab [17] and characterized under the scanning electron microscope for their uniformity of shape and size. The anti bacterial nature of silver nanoparticles by their ability to affect the cell signaling mechanisms have been proved by various studies [17].…”

“…Stable silver nanoparticles have been synthesized in the lab [17] and characterized under the scanning electron microscope for their uniformity of shape and size. The anti bacterial nature of silver nanoparticles by their ability to affect the cell signaling mechanisms have been proved by various studies [17]. In this study, we have tried to elucidate the anti thrombotic role of nano silver.…”