RETRACTED: BMSCs-derived exosomal microRNA-150-5p attenuates myocardial infarction in mice

Wu, Zheng; Cheng, Shujuan; Wang, Shaoping; Li, Wenzheng; Liu, Jinghua

doi:10.1016/j.intimp.2021.107389

Cited by 37 publications

(35 citation statements)

References 25 publications

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“…In vitro studies suggested the cellular mechanisms of this effect was in part due to prevention of cardiomyocyte apoptosis and fibroblast activation and that this was likely due to miRNAs transported in the stem cell exosomes. Similar studies illustrated that treatment of mice with exosomes derived from bone marrow mesenchymal stem cells preserved myocardial function and inhibited cardiomyocyte apoptosis following infarction [ 109 ]. These effects were mediated by the targeting of Bax by exosome-derived miR-150-5p.…”

Section: Role Of Exosomes In Fibrosis and Fibroblast Activationmentioning

confidence: 88%

Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis

Hohn

Tan

Carver

et al. 2021

Cells

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Alterations in the accumulation and composition of the extracellular matrix are part of the normal tissue repair process. During fibrosis, this process becomes dysregulated and excessive extracellular matrix alters the biomechanical properties and function of tissues involved. Historically fibrosis was thought to be progressive and irreversible; however, studies suggest that fibrosis is a dynamic process whose progression can be stopped and even reversed. This realization has led to an enhanced pursuit of therapeutic agents targeting fibrosis and extracellular matrix-producing cells. In many organs, fibroblasts are the primary cells that produce the extracellular matrix. In response to diverse mechanical and biochemical stimuli, these cells are activated or transdifferentiate into specialized cells termed myofibroblasts that have an enhanced capacity to produce extracellular matrix. It is clear that interactions between diverse cells of the heart are able to modulate fibroblast activation and fibrosis. Exosomes are a form of extracellular vesicle that play an important role in intercellular communication via the cargo that they deliver to target cells. While relatively recently discovered, exosomes have been demonstrated to play important positive and negative roles in the regulation of fibroblast activation and tissue fibrosis. These roles as well as efforts to engineer exosomes as therapeutic tools will be discussed.

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Section: Role Of Exosomes In Fibrosis and Fibroblast Activationmentioning

confidence: 88%

Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis

Hohn

Tan

Carver

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…Identically, another literature has also implied that exosomes extracted from BMSCs activate cell viability in oxygen-glucose deprivation/reoxygenation and constrain the pyroptosis, thereby mitigating the cerebral I/R injury [7]. Similarly, Wu et al have unearthed that miR-150-5p from exosomes of BMSCs can protect cardiac function, mitigate pathological changes of myocardium and reduce apoptosis rate of cardiomyocytes in myocardial infarction mice [35]. However, the literatures about effects of the exosomal miR-150-5p from BMSCs on cerebral I/R injury are inadequate, yet these preceding ndings still offered valuable references and basement for our study.…”

Section: Discussionmentioning

confidence: 99%

Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting B-cell translocation gene 2

Yang

2021

Preprint

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Objective MicroRNA(miR)-150-5p has been investigated in many studies, while the role of exosomal miR-150-5p from bone marrow mesenchymal stromal cells (BMSCs) on cerebral ischemia/reperfusion (I/R) injury remains extensive exploration. This research aims to probe the protective effects of exosomal miR-150-5p from BMSCs on cerebral I/R injury via regulating B-cell translocation gene 2 (BTG2). Methods BMSCs were cultured and transfected with miR-150-5p mimic, then exosomes from BMSCs were extracted. Middle cerebral artery occlusion (MCAO) rat model was established, and miR-150-5p and BTG2 levels in rat brain tissues were detected. Then gain and loss-function assays were conducted to probe the impact of exosomes, miR-150-5p and BTG2 on neurological function, pathological changes, apoptosis and inflammatory factors of MCAO rats. The binding relationship between miR-150-5p and BTG2 was validated. Results MiR-150-5p was decreased and BTG2 was augmented in MCAO rats. The exosomes from BMSCs could improve neurological function, pathological changes, apoptosis and reduce inflammatory factors in MCAO rats. Enriched miR-150-5p or decreased BTG2 could enhance the protective effects of exosomes from BMSCs on cerebral I/R injury. The elevated BTG2 reversed the impacts of enriched exosomal miR-150-5p. BTG2 was targeted by miR-150-5p. Conclusion Exosomal miR-150-5p from BMSCs exerts protective effects on cerebral I/R injury via repressing BTG2. This study provided novel therapeutic strategies for treatment of cerebral I/R injury.

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“…After intramyocardial administration, the apoptosis of CMs and endothelial cells was prevented and the cardiac dysfunction was attenuated [ 133 , 134 ]. Other miRNAs in curative exosomes, such as miR-148a, miR-1271-5p, miR-19a, and miR-150-5p, were found to be critical for the treatment of MI, demonstrating the potential of these molecules to be targets of non-viral delivery systems for cardiac recovery [ 135 , 136 , 137 , 138 ].…”

Section: Modulating Different Cells For MI Treatmentmentioning

confidence: 99%

Non-Viral Gene Delivery Systems for Treatment of Myocardial Infarction: Targeting Strategies and Cardiac Cell Modulation

Wang

Zhou

et al. 2021

Pharmaceutics

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Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. Conventional therapies involving surgery or pharmacological strategies have shown limited therapeutic effects due to a lack of cardiac tissue repair. Gene therapy has opened an avenue for the treatment of cardiac diseases through manipulating the underlying gene mechanics. Several gene therapies for cardiac diseases have been assessed in clinical trials, while the clinical translation greatly depends on the delivery technologies. Non-viral vectors are attracting much attention due to their safety and facile production compared to viral vectors. In this review, we discuss the recent progress of non-viral gene therapies for the treatment of cardiovascular diseases, with a particular focus on myocardial infarction (MI). Through a summary of delivery strategies with which to target cardiac tissue and different cardiac cells for MI treatment, this review aims to inspire new insights into the design/exploitation of non-viral delivery systems for gene cargos to promote cardiac repair/regeneration.

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RETRACTED: BMSCs-derived exosomal microRNA-150-5p attenuates myocardial infarction in mice

Cited by 37 publications

References 25 publications

Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis

Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis

Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting B-cell translocation gene 2

Non-Viral Gene Delivery Systems for Treatment of Myocardial Infarction: Targeting Strategies and Cardiac Cell Modulation

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