RETRACTED: Autophagy regulates the Wnt/GSK3β/β-catenin/cyclin D1 pathway in mesenchymal stem cells (MSCs) exposed to titanium dioxide nanoparticles (TiO2NPs)

Yu, Shunbang; Wang, Rui; Bi, Yujie; Wang, Pu; Zhang, Rui; Bohatko-Naismith, Joanna; Zhang, Xudong; Wang, He

doi:10.1016/j.toxrep.2020.08.020

Cited by 4 publications

(3 citation statements)

References 51 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies discovered that TiO 2 NPs caused cell toxicology, while others reported that the proliferation and survival were enhanced in human fibroblast cells, epithelium, and osteoblasts cultured on TiO 2 NP-treated titanium surfaces [139]. Wang, H., has shown that autophagy regulates the Wnt/GSK3/βcatenin/cyclin D1 pathway in TiO 2 -stimulated BMSCs to stimulate cell proliferation, autophagy-related protein (LC3II/I) expression in a TiO 2 NP concentration-dependent manner, which indicates that autophagy may be an essential mechanism for maintaining cell homeostasis under TiO 2 -stimulated cell stress conditions [140]. Our studies used the exosomes from BMP2-stimulated macrophages to intrigue titanium oxide nanotubes to promote bone regeneration [115].…”

Section: Titanium Dioxide Nanotubes (Tio2 Nts) and Alumina Nanoparticles (Al2o3)mentioning

confidence: 99%

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Zhang

Xiao

2021

Pharmaceutics

View full text Add to dashboard Cite

Porous nanomaterials (PNMs) are nanosized materials with specially designed porous structures that have been widely used in the bone tissue engineering field due to the fact of their excellent physical and chemical properties such as high porosity, high specific surface area, and ideal biodegradability. Currently, PNMs are mainly used in the following four aspects: (1) as an excellent cargo to deliver bone regenerative growth factors/drugs; (2) as a fluorescent material to trace cell differentiation and bone formation; (3) as a raw material to synthesize or modify tissue engineering scaffolds; (4) as a bio-active substance to regulate cell behavior. Recent advances in the interaction between nanomaterials and cells have revealed that autophagy, a cellular survival mechanism that regulates intracellular activity by degrading/recycling intracellular metabolites, providing energy/nutrients, clearing protein aggregates, destroying organelles, and destroying intracellular pathogens, is associated with the phagocytosis and clearance of nanomaterials as well as material-induced cell differentiation and stress. Autophagy regulates bone remodeling balance via directly participating in the differentiation of osteoclasts and osteoblasts. Moreover, autophagy can regulate bone regeneration by modulating immune cell response, thereby modulating the osteogenic microenvironment. Therefore, autophagy may serve as an effective target for nanomaterials to facilitate the bone regeneration process. Increasingly, studies have shown that PNMs can modulate autophagy to regulate bone regeneration in recent years. This paper summarizes the current advances on the main application of PNMs in bone regeneration, the critical role of autophagy in bone regeneration, and the mechanism of PNMs regulating bone regeneration by targeting autophagy.

show abstract

Section: Titanium Dioxide Nanotubes (Tio2 Nts) and Alumina Nanoparticles (Al2o3)mentioning

confidence: 99%

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Zhang

Xiao

2021

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…[90] Another study revealed that TiO 2 NPs elicited autophagy in MSC cells, and the activation of autophagy stimulated the secretion of Wnt, which further promoted the expression of cyclin D1 through the Wnt/GSK3β/β-catenin pathway, ultimately boosting cell proliferation. [91] Zhang et al [44] reported that TiO 2 NPs were mainly distributed in lysosomes after entering HTR-8 cells, causing lysosomal dysfunction and leading to protein leakage. The ensuing disruption of protein homeostasis and leaked TiO 2 NPs disrupted mitochondria, in which autophagy was activated to clear the damaged mitochondria.…”

Section: Ionps Have Been Described To Activate Autophagy In Gbm Cells...mentioning

confidence: 99%

Section: Autophagy Regulation By Inorganic Npsmentioning

confidence: 99%

Autophagy regulation by inorganic, organic, and organic/inorganic hybrid nanoparticles: Organelle damage, regulation factors, and potential pathways

Dong

Zhang

Tang

2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

The rapid development of nanotechnology requires a more thorough understanding of the potential health effects caused by nanoparticles (NPs). As a programmed cell death, autophagy is one of the biological effects induced by NPs, which maintain intracellular homeostasis by degrading damaged organelles and removing aggregates of defective proteins through lysosomes. Currently, autophagy has been shown to be associated with the development of several diseases. A significant number of research have demonstrated that most NPs can regulate autophagy, and their regulation of autophagy is divided into induction and blockade. Studying the autophagy regulation by NPs will facilitate a more comprehensive understanding of the toxicity of NPs. In this review, we will illustrate the effects of different types of NPs on autophagy, including inorganic NPs, organic NPs, and organic/inorganic hybrid NPs. The potential mechanisms by which NPs regulate autophagy are highlighted, including organelle damage, oxidative stress, inducible factors, and multiple signaling pathways. In addition, we list the factors influencing NPs‐regulated autophagy. This review may provide basic information for the safety assessment of NPs.

show abstract