RETRACTED: Astragalus polysaccharide promotes proliferation and osteogenic differentiation of bone mesenchymal stem cells by down-regulation of microRNA-152

Li, Qiang; Xing, Wen; Gong, Xilong; Wang, Yueshu; Sun, Hongbin

doi:10.1016/j.biopha.2019.108927

Cited by 22 publications

(15 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, glycyrrhizic acid has antiviral effects, and MSCs promote tissue repair and maintain homeostasis in BM microenvironments [62,63]. Second, damage to hematopoietic stem/progenitor cells can be treated using Astragalus polysaccharide to promote the recovery of hematopoietic function [64]. Combining Astragalus polysaccharides with rhTPO or TPORA may serve as a promising regimen to treat hematopoietic cell damage and reduce TPO production.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Zhang

Zeng

Jiao

et al. 2020

Thrombosis Research

136

146

View full text Add to dashboard Cite

Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia and thrombocytopenia are not rare in COVID-19 patients, and a smaller population of these patients had leukopenia. Thrombocytopenia was detected in 5-41.7% of the patients with COVID-19. Analyzing the dynamic decrease in platelet counts may be useful in the prognosis of patients with COVID-19. However, the mechanisms underlying the development of thrombocytopenia remain to be elucidated. This review summarizes the hematological changes in patients infected with SARS-CoV-2 and possible underlying mechanisms of thrombocytopenia development. Coronavirus types and their receptorsSix types of human CoVs have been identified till date: HCoV-NL63 and HCoV-229E are Alphacoronaviruses and HCoV-OC43, HCoVHKU1, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV) are Betacoronaviruses (Table I) [6-10]. SARS-CoV-2 is the seventh member of the RNA-containing enveloped CoV family. SARS-CoV-2 and SARS-CoV reside on different branches of the phylogenetic tree, but the genome of SARS-CoV-2 shares more than 85% homology with that of SARS-CoV [7]. HCoV-229E, OC43, NL63, and HKU1 cause mild respiratory diseases. The last two decades have seen fatal infections caused by SARS-CoV and MERS-CoV [8].CoVs use cell surface receptors to enter host cells [9]. SARS-CoV primarily binds to the angiotensin-converting enzyme 2 (ACE2) [10], whereas MERS-CoV interacts with dipeptidyl peptidase 4 (DPP4; also known as CD26; Table I). Similar to SARS-CoV, COVID-19 develops upon binding of SARS-CoV-2 viral particles to ACE2, but not to other CoV receptors, such as aminopeptidase N and DPP4 [7]. SARS-CoV has similar antigenic characteristics as human 12]. HCoV-229E enters monocytes and macrophages via CD13 and induces cell apoptosis [13]. In addition, Betacoronaviruses can utilize CEACAMla (CD66a) as receptors [4,14]. Clinical manifestations and treatment of COVID-19Patients with COVID-19 can be divided into four categories based on their clinical manifestations: light, common, severe, and critical. Guan et al. performed a retrospective study (n = 1099) demonstrated that COVID-19 is associated with a wide range of symptoms [1]. Fever

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Zhang

Zeng

Jiao

et al. 2020

Thrombosis Research

136

146

View full text Add to dashboard Cite

show abstract

“…In vivo (Deng et al, 2012;Qiu and Cheng, 2019) In vitro (Yuan et al, 2008;Yin et al, 2012) may also be attributed to the downregulation of miR-127, as well as the adjustment of the JNK, NF-kB, and PI3K/AKT signaling pathways (Ren et al, 2018). APS can promote the proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) by upregulating BMP9, during which overexpression of BMP9 activates the PI3K/AKT and Wnt/b-catenin signaling pathways (Li Q. et al, 2019). APS can also partially suppress pulmonary artery remodeling through endothelial nitric oxide synthase/nitric oxide and the NF-kB signaling pathway to improve monocrotaline-induced pulmonary hypertension (Yuan L.B.…”

Section: Downregulationmentioning

confidence: 99%

A Review of the Pharmacological Action of Astragalus Polysaccharide

et al. 2020

View full text Add to dashboard Cite

Astragalus membranaceus (A. membranaceus) is a type of traditional Chinese medicine with a long history of clinical application. It is used in the improvement and treatment of various diseases as medicine and food to invigorate the spleen and replenish qi. The main components of A. membranaceus are Astragalus polysaccharide (APS), flavonoids compounds, saponins compounds, alkaloids, etc. APS is the most important natural active component in A. membranaceus, and possesses multiple pharmacological properties. At present, APS possess the huge potential to develop a drug improving or treating different diseases. In this review, we reveal the potential approaches of pretreating and preparation on APS as much as possible and the study on content of APS and its chemical composition including different monosaccharides. More importantly, this paper summarize pharmacological actions on immune regulation, such as enhancing the immune organ index, promoting the proliferation of immune cells, stimulating the release of cytokines, and affecting the secretion of immunoglobulin and conduction of immune signals; anti-aging; anti-tumor by enhancing immunity, inducing apoptosis of tumor cells and inhibiting the proliferation and transfer of tumor cells; antiviral effects; regulation of blood glucose such as type I diabetes mellitus, type II diabetes mellitus and diabetic complications; lipid-lowering; anti-fibrosis; antimicrobial activities and anti-radiation. It provided theoretical basis for the further research such as its structure and mechanism of action, and clinical application of APS.

show abstract

“…69 Constituents of Radix Astragali and Radix Angelicae Sinensis 70 were reported to restore the hematopoietic function of hematopoietic stem cells (HSCs) by alleviating the destruction of HSCs mediated by the immune system. Astragaloside, Calycosin, 71 and Astragalus polysaccharide 72 may have an effect on BMSCs. Atractylode III 73 was found to regulate the adipogenic differentiation of BMSCs.…”

Section: Discussionmentioning

confidence: 98%

Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis

Yan

Feng

et al. 2021

Integr Cancer Ther

View full text Add to dashboard Cite

Objective: To evaluate the effectiveness of Chinese Herbal Medicine (CHM) on leukopenia/neutropenia induced by chemotherapy in adults with colorectal cancer (CRC). Methods: Eight electronic databases were searched from their inception to June 2020. Randomized controlled trials with clarified sequence generation were qualified. Two reviewers independently conducted the screening and data extraction. Methodological quality was assessed using the Risk of Bias tool. RevMan 5.4 was applied to the meta-analysis. Results: Twenty-seven studies involving 1867 participants were qualified, of which 26 were included in the quantitative synthesis. Meta-analysis showed that CHM significantly reduced the incidence of leukopenia induced by chemotherapy (RR = 0.69; 95% CI 0.59-0.82), as well as the grade 3/4 leukopenia (RR = 0.71; 95% CI 0.55-0.90). Meanwhile,CHM decreased the occurrence of neutropenia (RR = 0.52, 95% CI 0.35-0.77), especially for the grades 3/4 neutropenia (RR = 0.42, 95% CI 0.27-0.64). Twenty-six of the included studies focused on the adverse events related to CHM. Conclusion: CHM may relieve neutropenia/leukopenia induced by chemotherapy in adults with colorectal cancer.

show abstract

RETRACTED: Astragalus polysaccharide promotes proliferation and osteogenic differentiation of bone mesenchymal stem cells by down-regulation of microRNA-152

Cited by 22 publications

References 45 publications

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

A Review of the Pharmacological Action of Astragalus Polysaccharide

Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis

Contact Info

Product

Resources

About