RETRACTED ARTICLE: Vaginal misoprostol before copper IUD insertion after previous insertion failure:      a double-blind, placebo-controlled, parallel-group, randomised clinical trial

Rasheedy, Radwa; Tamara, Tarek; Allam, Ihab Serag; Abbas, Ahmed M.; Salam, Nermine Essam El-Din Abd El; Ahmed, Ahmed Ferhad

doi:10.1080/13625187.2019.1610871

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Misoprostol does not alter the angle of the cervical canal, but works by softening the cervix, and the dose of misoprostol used has few side effects and does not overdilate the cervix. 11,12 Before IUD removal, a detailed medical history should be taken to understand basic information regarding the patient's IUD (eg, IUD types). Zhao's doctoral thesis showed that among round, V-shaped, uterine, T-shaped, and other types of IUDs, the difficulty rate of round IUDs was the highest, followed by V-shaped ones; uterine IUDs were the easiest to remove.…”

Section: Discussionmentioning

confidence: 99%

Uterine Artery Rupture Caused by IUD Extraction: A Case Report

Wang¹,

Sun²

2022

IJWH

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Section: Discussionmentioning

confidence: 99%

Uterine Artery Rupture Caused by IUD Extraction: A Case Report

Wang¹,

Sun²

2022

IJWH

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“…Clinicians reported more easiness with premedication of either drugs, and women in both groups were satisfied with IUCD insertion. Furthermore, Rasheedy et al [15] reported that, vaginal misoprostol prior to IUCD insertion in parous females with previous failure increased the success rate, particularly in females with previous caesarean section.…”

Section: Disucssionmentioning

confidence: 99%

Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery.

Elgharbawy

Oun

Ayad

2020

International Journal of Medical Arts

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Background:The intrauterine device [IUD] is a safe and effective method of contraception, fear of pain during insertion discourages some providers to recommend IUDs to women with no previous vaginal delivery. Aim of the work:The aim of the study is to evaluate sublingual misoprostol 200µg on the cervix one hour before IUD insertion; to facilitate IUD insertion in women with tight cervix or in whom did not deliver vaginally. Patients and Methods: The study was a double blinded randomized controlled trial, compared sublingual 200µg misoprostol with placebo. The study included 260 cases attended the Gynecology Clinic [Al-Azhar University Hospital] from December 2018 to November 2019. All females signed an informed written consent, and then have been randomly divided into 2 groups using a closed envelope technique. Every female had been asked to take the drug sublingually then return after one hour to insert her IUD. Group A included 130 females who used sublingual misoprostol 200µg [Misotac] and group B included 130 females who took a placebo one hour before IUD insertion [Control group]. Results: IUD and uterine sound insertion was unsuccessful in 8.5% of group A versus 13.8% in group B while it was successful in 91.5% of group A versus 86.2% in Group B. Among the successful cases, 88[73.9] were easy in group A versus 77[68.8] in group B. On the other hand, 31[26.1%] and 35[31.2%] were difficult in group A and B respectively. With no significant difference between both groups either in IUD or uterine sound insertion successful or easiness rate [p=0.17 & 0.38 respectively]Conclusion: Using of misoprostol to facilitate IUD insertion in women with tight cervix, has no role in pain reduction or increase the ease of IUD insertion, although results with misoprostol are superior to placebo, but the different did not reach statistical significance.

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“…To avoid the surgical complications researchers have tried medications to induce abortions. The most widely researched ones are prostaglandins alone, mifepristone alone, methotrexate alone, mifepristone with prostaglandins, methotrexate with prostaglandins and Misoprostol [4][5][6] . Multiple investigators have evaluated alternative medical abortion regimens to simplify the treatment process and extend the gestational age range.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of misoprostol after 6 hours of mifepristone in medical abortions up to 7 weeks v/s 24 hours: A comparative study

Nagaich¹,

Maheswari²

2020

Int. J. Clin. Obstet. Gynaecol.

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Background/purpose: The aim of the study was to compare the Efficacy and Safety of Misoprostol after 6 Hours of Mifepristone in Medical Abortions up to 7 weeks v/s 24 Hours. Material and method: The present randomized clinical trial was undertaken in the department of Obstetrics and Gynaecology at Muzaffarnagar medical college and hospital among 60 women seeking abortion up to 7 weeks (49 days). The subjects were divided into two groups i.e. group A (tablet Mifepristone 200mg orally on empty stomach and after 24hrs, 400 microgram Tablet Misoprostol given orally), group B (tablet Mifepristone 200 microgram followed by misoprostol 400 microgram after 6hours). Success was defined as complete expulsion of products of conception within 24 hours of misoprostol Failure was defined as incomplete expulsion of products of conception within 24 hrs of misoprostol. Results: Mean age of the study subjects was 24.17±5.11 years and 23.93±4.08 years in group A and group B respectively. In group A and B, mean gestation age (in weeks) was 6.37±0.77 and 6.57±0.57 respectively. Success was reported among 96.67% and 90% of the subjects in group A and B respectively with statistically insignificant difference. Conclusion:Based on the results of the present study, it can be concluded that women can use regimens with vaginal misoprostol without any time delay between medications with efficacy that is similar to those with a delay.

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RETRACTED ARTICLE: Vaginal misoprostol before copper IUD insertion after previous insertion failure: a double-blind, placebo-controlled, parallel-group, randomised clinical trial

Cited by 6 publications

References 14 publications

Uterine Artery Rupture Caused by IUD Extraction: A Case Report

Uterine Artery Rupture Caused by IUD Extraction: A Case Report

Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery.

Efficacy and safety of misoprostol after 6 hours of mifepristone in medical abortions up to 7 weeks v/s 24 hours: A comparative study

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