Background/purpose: To evaluate the effect of three different doses of letrozole in ovulation induction and its effect on gonadotropins dose in unexplained infertility. Material and method: It was a prospective study conducted in the department of Obstetrics and Gynecology, Muzaffarnagar Medical College, Muzaffarnagar among 180 patients of infertility. Selected infertility cases were divided in three groups i.e. 1) Group 1(60 cases) infertile women treat with letrozole 2.5 mg, 2) Group 2 (60 cases) infertile women treat with letrozole 5 mg and 3) Group 3 (60 cases) infertile women treat with letrozole 7.5 mg. The demographic details of the subjects were recorded. All women were evaluated on the 2nd day of cycle with transvaginal ultrasound for measuring endometrial thickness and an antral follicle count as well as follicular vascularity. Base line that is on 3 rd day of cycle serum FSH, LH levels were also measured in initial assessment. Group I, II and III received letrozole (Letrofem®; Iran hormone, Tehran, Iran) from day 3 of the cycle, 2.5 mg, 5mg, 7.5 mg orally per day for five days. Results: Maximum follicle and ET size was increased in subjects having letrozole 7.5 mg dose. Follicular number was 8 was reported among 70%, 68.33% and 61.67% of the subjects with 2.5mg, 5mg and 7.5mg letrozole dose respectively. Gonadotropin dose 1 and 2 was required by 45% and 35% of the subject's 7.5mg letrozole dose respectively. Conclusion:We have shown that letrozole, used in doses greater than those commonly employed, can produce enhanced follicular growth without detrimental effects upon the endometrium.
Background/purpose: The aim of the study was to compare the Efficacy and Safety of Misoprostol after 6 Hours of Mifepristone in Medical Abortions up to 7 weeks v/s 24 Hours. Material and method: The present randomized clinical trial was undertaken in the department of Obstetrics and Gynaecology at Muzaffarnagar medical college and hospital among 60 women seeking abortion up to 7 weeks (49 days). The subjects were divided into two groups i.e. group A (tablet Mifepristone 200mg orally on empty stomach and after 24hrs, 400 microgram Tablet Misoprostol given orally), group B (tablet Mifepristone 200 microgram followed by misoprostol 400 microgram after 6hours). Success was defined as complete expulsion of products of conception within 24 hours of misoprostol Failure was defined as incomplete expulsion of products of conception within 24 hrs of misoprostol. Results: Mean age of the study subjects was 24.17±5.11 years and 23.93±4.08 years in group A and group B respectively. In group A and B, mean gestation age (in weeks) was 6.37±0.77 and 6.57±0.57 respectively. Success was reported among 96.67% and 90% of the subjects in group A and B respectively with statistically insignificant difference. Conclusion:Based on the results of the present study, it can be concluded that women can use regimens with vaginal misoprostol without any time delay between medications with efficacy that is similar to those with a delay.
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