RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

Badehnoosh, Bita; Karamali, Maryam; Zarrati, Mitra; Jamilian, Mehri; Bahmani, Fereshteh; Tajabadi‐Ebrahimi, Maryam; Jafari, Parvaneh; Rahmani, Elham; Asemi, Zatollah

doi:10.1080/14767058.2017.1310193

Cited by 120 publications

(146 citation statements)

References 43 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…Potential mechanisms by which probiotics improve glucose metabolism include reduction in oxidative stress and inflammation, reduction in intestinal permeability, and increased secretion of incretins. In a study of 60 GDM women, 6 weeks of probiotic supplementation led to a significant reduction in serum high‐sensitivity C‐reactive protein and a significant increase in total anti‐oxidant capacity levels, along with reduction in fasting glucose levels. Probiotics have also been shown to increase the expression of adhesion proteins within the intestinal epithelium and to reduce intestinal permeability, leading to less systemic inflammation that might contribute to less insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…This should be explored in future research. Although some studies used longer treatment periods, the intervention period in the present was just 4 weeks, and we used two‐strain probiotics, whereas some investigators used probiotics with four strains. The decision to use the two‐strain probiotic was driven by their availability and approval at our institution for treatment of other conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the impact of probiotics on various outcomes has been shown, including dermatological diseases 11 , gastrointestinal diseases [12][13][14] and metabolic disorders 15,16 . Recently, several studies from different countries (i.e., Iran, Ireland and Turkey) have shown the favorable effects of probiotic supplements with diverse compositions and durations of therapy on glycemic control in pregnant women with GDM [17][18][19][20][21][22][23] . However, the impact of probiotics in South-East Asian populations has not been reported.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double‐blind randomized controlled trial

Kijmanawat

Panburana

Reutrakul

et al. 2018

J of Diabetes Invest

123

128

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double‐blind randomized controlled trial

Kijmanawat

Panburana

Reutrakul

et al. 2018

J of Diabetes Invest

123

128

View full text Add to dashboard Cite

show abstract

“…After reading the titles and abstracts, 54 studies were selected for further review. Finally, thirteen studies met our inclusion criteria [22][23][24][25][26][27][28][29][30][31][32][33][34]. The detailed process of the search strategy is described in Figure 1.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Jin

Sha

Dong

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and nutritional therapy is the basis of GDM treatment. However, the effects of different forms of nutritional supplementation on improving gestational diabetes are uncertain. Objective. We conducted a network meta-analysis to evaluate the effects of supplementation with different nutrients on glucose metabolism in women with GDM. Methods. We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. The Cochrane tool was used to assess the risk of bias. Pairwise meta-analysis and network meta-analysis were used to compare and rank the effects of nutritional strategies for the improvement of fasting plasma glucose (FPG), serum insulin, and homeostasis model assessment-insulin resistance (HOMA-IR). Results. We included thirteen RCTs with a total of 754 participants. Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Network analysis showed that vitamin D supplementation was superior to omega-3 (-3.64 mg/dL, 95% CI: -5.77 to -1.51), zinc (-5.71 mg/dL, 95% CI: -10.19 to -1.23), probiotics (-6.76 mg/dL, 95% CI: -10.02 to -3.50), and placebo (-12.13 mg/dL, 95% CI: -14.55 to -9.70) for improving FPG. Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 μIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 μIU/mL; 95% CI-11.95, -3.65). Vitamin D was more effective than probiotics (-0.99, 95% CI: -1.84 to -0.14) and placebo (-1.80, 95% CI: -2.45 to -1.16) for improving HOMA-IR. Conclusion. Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Nutrient supplementation seemed to have an effect on glucose homeostasis maintenance in patients with GDM and may be considered an adjunctive therapy.

show abstract

“…The ferric reducing ability of plasma, thiobarbituric acid and high performance liquid chromatography (KNAUER) methods were used to assay serum values of total antioxidant capacity (TAC), malodialdehyde (MDA) and ALA, respectively. As an index of oxidative stress, the MDA/TAC ratio was calculated …”

Section: Methodsmentioning

confidence: 78%

Reduction in maternal serum values of glucose and gamma‐glutamyltransferase after supplementation with alpha‐lipoic acid in women with gestational diabetes mellitus

Aslfalah

Jamilian

Rafiei

et al. 2018

J of Obstet and Gynaecol

Self Cite

View full text Add to dashboard Cite

Aim: Alpha-lipoic acid (ALA) is a short chain fatty acid which has a key role in energy production. ALA is also known as a universal antioxidant. The aim of the present study was to explore the effects of ALA supplementation in women with gestational diabetes mellitus. Methods: A randomized double-blind placebo-controlled clinical trial study was designed. Women with gestational diabetes mellitus (n = 60) during 24-28 weeks of gestation were selected and divided randomly into drug (n = 30) and placebo (n = 30) groups. Drug group supplemented with ALA (100 mg/day) for 8 weeks. The biochemical markers were measured before and after the intervention and considered significant at a P-value less than 0.05. Results: Maternal circulating values of fasting blood sugar (P < 0.001), gamma-glutamyltransferase (P < 0.001) and alanine transaminase (P = 0.031) were decreased in the drug group after the intervention. However, values of urea, creatinine, uric acid, aspartate transaminase and alkaline phosphatase were not changed significantly after the trial. Conclusion: The present study has shown that supplementation with 100 mg/day of ALA had some beneficial effects on glucose metabolism and liver function in women with gestational diabetes mellitus.

show abstract

RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

Abstract: Overall, probiotic supplementation among women with GDM for six weeks had beneficial effects on FPG, serum hs-CRP, plasma TAC, MDA and oxidative stress index, but did not affect pregnancy outcomes.

Cited by 120 publications

References 43 publications

Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double‐blind randomized controlled trial

Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double‐blind randomized controlled trial

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Reduction in maternal serum values of glucose and gamma‐glutamyltransferase after supplementation with alpha‐lipoic acid in women with gestational diabetes mellitus

Contact Info

Product

Resources

About