Reduction in maternal serum values of glucose and gamma‐glutamyltransferase after supplementation with alpha‐lipoic acid in women with gestational diabetes mellitus

Abstract

Aim: Alpha-lipoic acid (ALA) is a short chain fatty acid which has a key role in energy production. ALA is also known as a universal antioxidant. The aim of the present study was to explore the effects of ALA supplementation in women with gestational diabetes mellitus. Methods: A randomized double-blind placebo-controlled clinical trial study was designed. Women with gestational diabetes mellitus (n = 60) during 24-28 weeks of gestation were selected and divided randomly into drug (n = 30) and placebo (n = 30) groups. Drug group supplemented with ALA (100 mg/day) for 8 weeks. The biochemical markers were measured before and after the intervention and considered significant at a P-value less than 0.05. Results: Maternal circulating values of fasting blood sugar (P < 0.001), gamma-glutamyltransferase (P < 0.001) and alanine transaminase (P = 0.031) were decreased in the drug group after the intervention. However, values of urea, creatinine, uric acid, aspartate transaminase and alkaline phosphatase were not changed significantly after the trial. Conclusion: The present study has shown that supplementation with 100 mg/day of ALA had some beneficial effects on glucose metabolism and liver function in women with gestational diabetes mellitus.

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

“…Overall, these data represent the first evidence that Myo is able to improve endothelial stress/damage in vascular cells by modulating inflammation and oxidative stress related to diabetes. These effects are comparable to the protective vascular action of LA, a molecule with well-known antioxidant effects that has demonstrated safety as well as beneficial effects on glycemia and liver enzymes as well as on lipid profiles and on adiponectin/leptin ratios in women affected by either GDM or polycystic ovary syndrome [ 8 , 27 , 30 , 31 , 32 , 33 ].…”

The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

“…The present network metanalysis provides a global comparison and ranking of these interventions. Network metanalysis allows assessment of dietary supplements not directly compared in the same study [ 90 , 91 ] and ranks the compared interventions to identify the optimal one, based on their probability to be the most effective, as expressed by the SUCRA values [ 12 ] (References [ 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 ] are cited in the supplementary materials ). Furthermore, this is the first study providing, via GRADE, an overview of the quality of the current evidence for the dietary interventions in women with GDM.…”

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

“…Additional 139 papers were excluded due to being pre-print papers ( n = 2), study protocols ( n = 6), reporting data from studies lacking of an appropriate placebo-controlled design for the supplementation ( n = 64), lacking of randomisation ( n = 5), testing the acute effect of ALA supplementation ( n = 7), testing ALA supplementation combined in nutraceutical compounds ( n = 27), testing intravenous treatment with ALA ( n = 11), testing topical treatment with ALA ( n = 4), lacking sufficient information about the nature of the adverse events ( n = 9), or reporting data overlapped with other publications ( n = 4) ( Supplementary file B ). Finally, 71 studies were eligible and included in the systematic review [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ,…”