RETRACTED ARTICLE: Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL–PEG–PCL for controlled delivery of 5FU

Abstract

Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by ε-caprolactone (PCL) and polyethylene glycol (PEG2000). We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated FeO magnetic nanoparticles modified with PCL-PEG-PCL copolymer. Chemical structure and magnetic properties of 5FU-loaded magnetic-polymer nanoparticles were investigated systematically by employing FT-IR, XRD, VSM and SEM techniques. In vitro release profile of 5FU-loaded NPs was also determined. The results showed that the encapsulation efficiency value for nanoparticles were 90%. Moreover, the release of 5FU is significantly higher at pH 5.8 compared to pH 7.4. Therefore, these nanoparticles have sustained release and can apply for cancer therapy.

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

“…Current investigations have also synthesized IONPs employing different shells with anticancer agents conventionally administered, such as β-cyclodextrin [ 135 ], carmustine [ 136 ], cetuximab [ 137 , 138 , 139 ], cytarabine [ 140 ], daunomycin [ 141 ], docetaxel [ 142 , 143 ], epirubicin [ 144 ], 5-fluorouracil [ 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 ], gemcitabine [ 22 , 154 , 155 , 156 , 157 , 158 ], methotrexate [ 159 , 160 , 161 ], mitoxantrone [ 162 , 163 , 164 , 165 ] and paclitaxel [ 27 , 104 , 166 , 167 , 168 , 169 , 170 , 171 , 172 ]. It is noteworthy, however, that these nanosystems demonstrate magnetic properties only in the presence of external magnetic fields to prevent agglomerations of nanoparticles [ 111 ] and to allow a satisfactory performance in the target sites.…”

The effect of chrysin–curcumin-loaded nanofibres on the wound-healing process in male rats

“…Previous studies have reported that Chrysin possesses potent anti-inflammatory and anti-oxidant properties [29,30]. On the other hand, curcumin is a naturally occurring polyphenolic compound with a broad range of favourable biological functions, including anti-cancer, antioxidant and anti-inflammatory activities [31]. The low bioavailability and in vivo stability of curcumin, however, require the development of suitable carrier vehicles to deliver the molecule in a sustained manner at therapeutic levels.…”

Folic Acid Conjugated PEG-PCL-PEG Triblock Copolymer Nanoparticles for Enhanced Delivery of 5-Fluorouracil to HT29 Colon Cancer Cells

“…Furthermore, it has been demonstrated that hydrophobic/hydrophilic ratio has crucial role in stabilizing of formed micelle.it has been also reported the micelles formed by triblock copolymer are more advantageous over diblock formed micelles in terms of stability which is attributed to lower critical micelle concentration (CMC) of triblock copolymers [26]. PCL-PEG-PCL is a type of PCL/PEG based triblock which has been utilized as 5-FU nanocarrier [27]. A comprehensive evaluation on PCL/PEG based triblock, consisting PCL-PEG-PCL and PEG-PCL-PEG with different ratio of coplymerization, has demonstrated that CMC values of PEG-PCL-PEG type is about half of those measured for its identical PCL-PEG-PCL which indicates higher stability of PEG-PCL-PEG type [28].…”