RETRACTED ARTICLE: Rapid reduction of macular edema due to retinal vein occlusion with low-dose normobaric hyperoxia

Arroyo, Jorge G.; Seto, Brendan; Yamada, Keiko; Zeng, Ke; Minturn, Robert; Lemire, Colin A.

doi:10.1007/s00417-021-05128-w

Cited by 3 publications

(5 citation statements)

References 29 publications

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“…Studies have shown favorable effect of hyperoxia on retinal thickness in ischemic retinal vascular conditions. This supports the idea that retinal thickness can show alterations due to an hypoxia-induced mechanism [21][22] . Increased RNFLT has been shown secondary to local hypoxia and hypercapnia-induced dilatation of the retinal vessels in healthy participants [23] .…”

Section: Discussionsupporting

confidence: 88%

Effect of FFP2/N95 facemask wear on retinal and choroidal thickness profile in healthy subjects

Günay¹,

Kalkişim²,

Esenülkü³

et al. 2022

Int J Ophthalmol

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AIM: To investigate the influence of non-oil 95 (N95)/filtering facepiece 2 (FFP2) facemask wear on retinal thickness, choroidal thickness (CT), retinal nerve fiber layer thickness (RNFLT), and ganglion cell layer thickness (GCLT) in healthy subjects. METHODS: In this prospective study, 53 healthy participants who used FFP2/N95 facemask were enrolled. Participants underwent optical coherence tomography imaging before and at 1 and 4h following FFP2/N95 facemask wear. The last imaging session was performed 1h after FFP2/N95 removal. Retinal thickness, CT, RNFLT, and GCLT were assessed at each session. Vital parameters were also assessed. RESULTS: The pulse rate of the subjects significantly decreased at 1 and 4h compared to baseline values (P<0.05). No significant changes in retinal thickness, RNFLT, and GCLT were observed in the study. CT profile showed a significant increase at all measured locations except 1-mm temporal, 1-mm inferior and 2-mm inferior points following FFP2/N95 wear which turned to baseline values after FFP2/N95 removal. Pulse rate and CT changes at 4h were significantly correlated (P<0.05). CONCLUSION: Parasympathetic activation during FFP2/N95 facemask wear might have a role on elevated CT measurements in healthy individuals by virtue of increased choroidal blood flow.

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Section: Discussionsupporting

confidence: 88%

Effect of FFP2/N95 facemask wear on retinal and choroidal thickness profile in healthy subjects

Günay¹,

Kalkişim²,

Esenülkü³

et al. 2022

Int J Ophthalmol

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“…3,4 DME eyes saw a similar, although slightly reduced, response to NBH compared to eyes with oedema from retinal vein occlusion. 5 While NBH would be expected to decrease VEGF levels and improve the function of tight junctions in both conditions, the difference may be accounted for by impaired autoregulation in DM. 1 VA increased by an average of 2.42 letters in treated DME eyes, which was not significantly different than treated normal eyes (p = 0.20, Table 1).…”

Section: Normobaric Hyperoxia Rapidly Reduces Diabetic Macular Oedemamentioning

confidence: 99%

“…While the importance of ischaemia as a component of DME continues to be clarified, results from the current study as well as previous reports strongly support the benefit of hyperoxia as a treatment for retinal ischaemia and complications of diabetic retinopathy. 2,5 As the population of patients affected by DME grows, so does the burden of current treatments on individuals and the healthcare system. 1 Accordingly, the utility of NBH as a complementary or alternative treatment should be further explored.…”

Section: Normobaric Hyperoxia Rapidly Reduces Diabetic Macular Oedemamentioning

confidence: 99%

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Retracted: Normobaric hyperoxia rapidly reduces diabetic macular oedema

Lemire

Seto

Yamada

et al. 2021

Clinical Exper Ophthalmology

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“…5 Lemire et al and Arroyo et al found a rapid reduction of macular edema after 3 h of NBH treatment in patients with DME and RVO, respectively, demonstrating the exquisite sensitivity of the ischemic inner retina to supplemental oxygen. 4,6 Interestingly, Vinten et al found a delayed reduction of DME two hours after administration of pure oxygen, suggesting that reduction of macular edema may persist beyond the period of NBH treatment. 3 Finally, retinal hypoxia in diabetic patients is expected to be increased during hours of darkness.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal normobaric hyperoxia treatment in a case of chronic diabetic macular edema

Song

Lemire

Seto

et al. 2022

European Journal of Ophthalmology

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Purpose To study the long-term anatomic and physiologic effects of nocturnal normobaric hyperoxia (NNBH) in a patient with treatment-resistant diabetic macular edema (DME). Methods A 64-year-old diabetic man with bilateral DME requiring regular anti-VEGF treatments in both eyes was started on 5 LPM (40% FiO2) NNBH treatment 6-h per night. Visual acuity, OCT measurements of retinal thickness and volume, as well as the number of injections given in each eye were retrospectively examined one year prior and prospectively after initiation of NNBH, as well as before and after a planned 1-month discontinuation of NNBH. Results The patient received 12 anti-VEGF injections in the year prior to beginning NNBH treatment (4 OD; 8 OS) and did not require any injections after commencing NNBH treatment. Visual acuity improved and stabilized to 20/20 and macular edema rapidly resolved in both eyes following initiation of NNBH. After a planned 1-month NNBH vacation, DME recurred but quickly resolved once NNBH treatment was restarted. Conclusion This model case demonstrates that a 6-h NNBH regimen can be successful in treating DME and improving vision, without the need for intravitreal injections. NNBH is a more acceptable treatment regimen compared to 24-h continuous oxygen delivery and may provide a less invasive alternate method for treating DME in patients with diabetes. Further study is warranted.

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RETRACTED ARTICLE: Rapid reduction of macular edema due to retinal vein occlusion with low-dose normobaric hyperoxia

Cited by 3 publications

References 29 publications

Effect of FFP2/N95 facemask wear on retinal and choroidal thickness profile in healthy subjects

Effect of FFP2/N95 facemask wear on retinal and choroidal thickness profile in healthy subjects

Retracted: Normobaric hyperoxia rapidly reduces diabetic macular oedema

Nocturnal normobaric hyperoxia treatment in a case of chronic diabetic macular edema

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