<i>Retracted:</i> Normobaric hyperoxia rapidly reduces diabetic macular oedema

Lemire, Colin A.; Seto, Brendan; Yamada, Keiko; Arroyo, Jorge G.

doi:10.1111/ceo.13961

Cited by 1 publication

(2 citation statements)

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“…2 We and others have shown that much shorter duration NBH results in rapid reduction of DME, raising the question of what the ideal protocol should be for treatment. 3,4 In this case report we demonstrate that over a 1 year period, 6-h per day of 40% FIO2 nocturnal normobaric hyperoxia (NNBH) is sufficient to effectively treat DME, improve vision, and eliminate the need for intravitreal injections.…”

Section: Introductionmentioning

confidence: 84%

“…5 Lemire et al and Arroyo et al found a rapid reduction of macular edema after 3 h of NBH treatment in patients with DME and RVO, respectively, demonstrating the exquisite sensitivity of the ischemic inner retina to supplemental oxygen. 4,6 Interestingly, Vinten et al found a delayed reduction of DME two hours after administration of pure oxygen, suggesting that reduction of macular edema may persist beyond the period of NBH treatment. 3 Finally, retinal hypoxia in diabetic patients is expected to be increased during hours of darkness.…”

Section: Discussionmentioning

confidence: 99%

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Nocturnal normobaric hyperoxia treatment in a case of chronic diabetic macular edema

Song

Lemire

Seto

et al. 2022

European Journal of Ophthalmology

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Purpose To study the long-term anatomic and physiologic effects of nocturnal normobaric hyperoxia (NNBH) in a patient with treatment-resistant diabetic macular edema (DME). Methods A 64-year-old diabetic man with bilateral DME requiring regular anti-VEGF treatments in both eyes was started on 5 LPM (40% FiO2) NNBH treatment 6-h per night. Visual acuity, OCT measurements of retinal thickness and volume, as well as the number of injections given in each eye were retrospectively examined one year prior and prospectively after initiation of NNBH, as well as before and after a planned 1-month discontinuation of NNBH. Results The patient received 12 anti-VEGF injections in the year prior to beginning NNBH treatment (4 OD; 8 OS) and did not require any injections after commencing NNBH treatment. Visual acuity improved and stabilized to 20/20 and macular edema rapidly resolved in both eyes following initiation of NNBH. After a planned 1-month NNBH vacation, DME recurred but quickly resolved once NNBH treatment was restarted. Conclusion This model case demonstrates that a 6-h NNBH regimen can be successful in treating DME and improving vision, without the need for intravitreal injections. NNBH is a more acceptable treatment regimen compared to 24-h continuous oxygen delivery and may provide a less invasive alternate method for treating DME in patients with diabetes. Further study is warranted.

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Section: Introductionmentioning

confidence: 84%