RETRACTED ARTICLE: Notoginsenoside R1 alleviates TNF-α-induced pancreatic β-cell Min6 apoptosis and dysfunction through up-regulation of miR-29a

Chen, Xiabo; Wei, Renxiong; Jin, Tinglong; Du, Hanguang

doi:10.1080/21691401.2019.1624368

Cited by 9 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The WNT pathways are also important for β cell fate and insulin secretion 204 . Several WNT pathways, such as WNT3a/β‐catenin 204–206 and WNT4/PCP, 207 could improve β cell proliferation and insulin secretion. In‐depth dissections revealed that the activation of TCF7L2 and FoxO1 is key to this proproliferation effect of WNT3a/β‐catenin pathway 187,208,209 .…”

Section: Signaling Pathways In T2dmmentioning

confidence: 99%

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao

Tian

Zhang

et al. 2023

MedComm

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including vascular, visual, neurological, kidney, and liver diseases. Moreover, recent data suggest a mutual interplay between T2DM and Corona Virus Disease 2019 (COVID‐19). T2DM is characterized by insulin resistance (IR) and pancreatic β cell dysfunction. Pioneering discoveries throughout the past few decades have established notable links between signaling pathways and T2DM pathogenesis and therapy. Importantly, a number of signaling pathways substantially control the advancement of core pathological changes in T2DM, including IR and β cell dysfunction, as well as additional pathogenic disturbances. Accordingly, an improved understanding of these signaling pathways sheds light on tractable targets and strategies for developing and repurposing critical therapies to treat T2DM and its complications. In this review, we provide a brief overview of the history of T2DM and signaling pathways, and offer a systematic update on the role and mechanism of key signaling pathways underlying the onset, development, and progression of T2DM. In this content, we also summarize current therapeutic drugs/agents associated with signaling pathways for the treatment of T2DM and its complications, and discuss some implications and directions to the future of this field.

show abstract

Section: Signaling Pathways In T2dmmentioning

confidence: 99%

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao

Tian

Zhang

et al. 2023

MedComm

View full text Add to dashboard Cite

show abstract

“…The proinflammatory factor TNFα may produce damage in Min6 and rat primary islet β cells. NG-R1 has been demonstrated to ameliorate the effects of TNFα by positively regulating the expression of miR-29a, which is also mediated by Wnt/β-catenin and PI3K/AKT/GSK-3β signaling pathways, alleviating cell dysfunctions 69 (Table 1). Diabetic encephalopathy is aggravated by oxidative stress and inflammation.…”

Section: Roles Of Ng-r1 In Diabetesmentioning

confidence: 99%

<p>Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases</p>

Liu

Yang

et al. 2020

DDDT

View full text Add to dashboard Cite

Notoginsenoside (NG)-R1 is one of the main bioactive compounds from Panax notoginseng (PN) root, which is well known in the prescription for mediating the microcirculatory hemostasis in human. In this article, we mainly discuss NG-R1 in metabolism and the biological activities, including cardiovascular protection, neuro-protection, anti-diabetes, liver protection, gastrointestinal protection, lung protection, bone metabolism regulation, renal protection, and anti-cancer. The metabolites produced by deglycosylation of NG-R1 exhibit higher permeability and bioavailability. It has been extensively verified that NG-R1 may ameliorate ischemia-reperfusion (IR)-induced injury in cardiovascular and neuronal systems mainly by upregulating the activity of estrogen receptor α-dependent phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and nuclear factor erythroid-2-related factor 2 (NRF2) pathways and downregulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. However, no specific targets for NG-R1 have been identified. Expectedly, NG-R1 has been used as a main bioactive compound in many Traditional Chinese Medicines clinically, such as Xuesaitong, Naodesheng, XueShuanTong, ShenMai, and QSYQ. These suggest that NG-R1 exhibits a significant potency in drug development.

show abstract

“…NGR1 protects PC-12 cells from LPS-induced damage and apoptosis by decreasing pro-inflammatory cytokines expression (Sun et al, 2019). Meantime, NGR1 alleviates TNF-α-stimulated Min6 and rat primary islets β cells apoptosis via activation of Wnt/βcatenin and PI3K/AKT/GSK3β signalling pathway (Chen et al, 2019). Therefore, incorporating NGR1 into HA/nHAp hydrogel to form injectable, in situ-forming composite scaffold is an attractive concept for developing biomaterials and might provide a method to enhance bone defect repair by reducing the inflammation reaction.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of NGR1 promotes bone regeneration of injectable HA/nHAp hydrogels by anti-inflammation regulation via a MAPK/ERK signaling pathway

Liu

Zhang

Zheng

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Suitable bone grafts are commonly required to achieve successful bone regeneration, wherein much effort has been spent to optimize their osteogenesis. Increasing evidence has demonstrated that reducing the levels of TNF-α can enhance bone regeneration at the injury site. Notoginsenoside R1 (NGR1) has been extensively studied in the field of anti-inflammation and regenerative medicine. Nanosized hydroxyapatite (nHAp) possesses excellent biocompatibility and osteoconductivity. In this study, we fabricated a thermoresponsive, injectable hyaluronic acid/nHAp (HA/nHAp) composite hydrogel incorporated with NGR1 to promote bone regeneration. Furthermore, NGR1-HA/nHAp hydrogel could enhance bone regeneration than those of HA and HA/nHAp hydrogels, profited by the underlying osteoblastic mechanism that NGR1 could facilitate activation of the MAPK/ERK signaling pathway and down-regulate the expression of TNF-α, ultimately upregulated expression of osteogenic genes. In summary, the NGR1-HA/nHAp composite hydrogel with controlled inflammation, and excellent osteogenic effect, will have great potential for use in bone regeneration applications.

show abstract

RETRACTED ARTICLE: Notoginsenoside R1 alleviates TNF-α-induced pancreatic β-cell Min6 apoptosis and dysfunction through up-regulation of miR-29a

Abstract: View related articles View Crossmark data Citing articles: 1 View citing articles Notoginsenoside R1 alleviates TNF-a-induced pancreatic b-cell Min6 apoptosis and dysfunction through up-regulation of miR-29a

Cited by 9 publications

References 33 publications

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

<p>Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases</p>

Incorporation of NGR1 promotes bone regeneration of injectable HA/nHAp hydrogels by anti-inflammation regulation via a MAPK/ERK signaling pathway

Contact Info

Product

Resources

About