RETRACTED ARTICLE: MicroRNA-129-5p affects immune privilege and apoptosis of nucleus pulposus cells via regulating FADD in intervertebral disc degeneration

Li, Nan; Gao, Qi; Zhou, Wenli; Lv, Xiaoming; Yang, Xiaohong; Liu, Xiaoqi

doi:10.1080/15384101.2020.1732515

Cited by 22 publications

(18 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fas-associated death domain ( FADD ) mediates multiple death receptor-induced apoptotic signaling pathways and also plays a role in T cell proliferation and embryonic development. Its effect on tumor prognosis depends on the tumor type and cell environment, for example, it is a poor prognostic marker in head and neck tumor, lung cancer, and cervical cancer, while it is beneficial for thyroid cancer [ 44 ]. Lysosome-associated membrane protein-1 ( LAMP1 ) is a member of the lysosomal membrane protein involved in the induction of cell death.…”

Section: Discussionmentioning

confidence: 99%

Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma

Cheng

Yuan

2020

Disease Markers

View full text Add to dashboard Cite

Background. Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies in the world, with low survival and poor quality of life. Autophagy-associated genes (ATGs) have been reported to be involved in the initiation and progression of malignancies. Here, we aimed to investigate the association between autophagy-associated genes and the outcomes in HNSCC patients. Methods. We obtained ATGs with prognostic values by analyzing the datasets from The Cancer Genome Atlas (TCGA) and Human Autophagy Database (HADb). The enrichment functions of autophagy differential genes were analyzed by Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). The Kaplan-Meier method was applied to the survival curve analysis. A prognostic autophagy-related gene signature was established, and its independence was verified. Results. We acquired a total of 529 samples and 232 ATGs; further, we identified 45 genes associated with prognosis and built a prognosis autophagy signature based on risk score of 15 genes. Patients were divided into two groups based on risk scores. The Kaplan-Meier curve illustrated that the survival rate of the high-risk group was significantly lower than that of the low-risk group in both the training group and validation group. The ROC curve revealed that the risk score had the highest AUC value in the 3rd and 5th years, reaching 0.703 and 0.724, which are higher than other risk factors such as gender, age, and TNM stage. The nomogram further confirmed its weight in the prognosis of HNSCC patients. Through KEGG and GO enrichment analyses, we observed that ATGs were involved in the tumorigenesis and invasion of tumor by various mediating pathways. We gained 3 hub genes (MAP1LC3B, FADD, and LAMP1) and further analyzed the survival curves, mutations, differential expressions, and their roles in tumors on the online websites. Conclusion. We identified a novel autophagy-related signature that may provide promising biomarker genes for the treatment and prognosis of HNSCC. We need to validate its prognostic value by applying it to the clinic.

show abstract

Section: Discussionmentioning

confidence: 99%

Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma

Cheng

Yuan

2020

Disease Markers

View full text Add to dashboard Cite

show abstract

“…Furthermore, high miR-129-5p expression alleviated disc inflammation by promoting the apoptosis of macrophages and CD8 + cells. Collectively, miR-129-5p exerts effects not only on NPCs, but also on inflammatory cells, although its targets in the latter have not yet been verified (13,134). Contrary to the aforementioned results, one study reported that miR-129-5p increased NPC apoptosis by suppressing autophagy (135).…”

Section: Diabetesmentioning

confidence: 96%

Role of microRNA‑129 in cancer and non‑cancerous diseases (Review)

2021

View full text Add to dashboard Cite

An increasing number of studies indicate that microRNAs (miRNAs/miRs) are involved in diverse biological signaling pathways and play important roles in the progression of various diseases, including both oncological and non-oncological diseases. These small non-coding RNAs can block translation, resulting in a low expression level of target genes. miR-129 is an miRNA that has been the focus of considerable research in recent years. A growing body of evidence shows that the miR-129 family not only functions in cancer, including osteosarcoma, nasopharyngeal carcinoma, and ovarian, prostate, lung, breast and colon cancer, but also in non-cancerous diseases, including heart failure (HF), epilepsy, Alzheimer's disease (AD), obesity, diabetes and intervertebral disc degeneration (IVDD). It is therefore necessary to summarize current research progress on the role of miR-129 in different diseases. The present review includes an updated summary of the mechanisms of the miR-129 family in oncological and non-oncological diseases. To the best of our knowledge, this is the first review focusing on the role of miR-129 in non-cancerous diseases such as obesity, HF, epilepsy, diabetes, IVDD and AD. Contents 1. Introduction 2. Role of miR-129 in oncological phenotypes 3. Role of miR-129 in non-oncological phenotypes 4. Conclusion

show abstract

“…miR-210 may also be a new target for IDD treatment. Similarly, Li et al [79] showed that miR-129-5p had a protective effect against IDD. The upregulation of miR-129-5p can promote the proliferation of NPCs and reduce the expression of FADD in IDD rats.…”

Section: Rna Interferencementioning

confidence: 88%

Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy

Zhang¹,

Hu²,

Peng³

et al. 2021

Int. J. Med. Sci.

View full text Add to dashboard Cite

Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process associated with low back pain (LBP). The pathogenesis is complicated, and the main pathological changes are IVD cell apoptosis and extracellular matrix (ECM) degradation. Apoptotic cell loss leads to ECM degradation, which plays an essential role in IDD pathogenesis. Apoptosis regulation may be a potential attractive therapeutic strategy for IDD. Previous studies have shown that IVD cell apoptosis is mainly induced by the death receptor pathway, mitochondrial pathway, and endoplasmic reticulum stress (ERS) pathway. This article mainly summarizes the factors that induce IDD and apoptosis, the relationship between the three apoptotic pathways and IDD, and potential therapeutic strategies. Preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit IVD cell apoptosis and slow IDD progression. Targeted apoptotic pathway inhibition may be an effective strategy to alleviate IDD at the gene level. This manuscript provides new insights and ideas for IDD therapy.

show abstract

RETRACTED ARTICLE: MicroRNA-129-5p affects immune privilege and apoptosis of nucleus pulposus cells via regulating FADD in intervertebral disc degeneration

Cited by 22 publications

References 25 publications

Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma

Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma

Role of microRNA‑129 in cancer and non‑cancerous diseases (Review)

Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy

Contact Info

Product

Resources

About