Retracted Article: Long noncoding RNA HOTAIR promotes cell apoptosis by sponging miR-221 in Parkinson's disease

Zhou, Fan; Xie, Shuanglun; Li, Juan; Duan, Shujie

doi:10.1039/c9ra06107j

Cited by 4 publications

(2 citation statements)

References 40 publications

(31 reference statements)

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“…lncRNAs and circRNAs are crucial in numerous neurodegenerative pathologies too [ 138 ] and evidence of RNAs balance disruption and ceRNA crosstalk was observed in Alzheimer’s and Parkinson’s disease [ 139 , 140 ] and Spinocerebellar Ataxia Type 7 (SCA7). In particular, several lncRNAs are known to exhibit abnormal expression in several types of cancers and in brain disorders, like lncRNA HOX transcript antisense intergenic RNA (HOTAIR) that exerts its regulatory roles in cell apoptosis by sponging miR-221 in specific Parkinson’s disease cell lines [ 141 ], or in the same context of Parkinson’s disease, like lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), through its involvement in dendritic and synapse development. An investigation into the role of MALAT1 in animal and in vitro models revealed its ceRNA function is linked to neuron apoptosis through the sponge effect on miR-124 [ 142 ].…”

Section: Cerna and Diseasesmentioning

confidence: 99%

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

Ala

2020

Cells

127

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MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and non-coding RNA molecules can be targeted by the same miRNAs and can indirectly regulate each other by competing for them. These RNAs, otherwise known as competing endogenous RNAs (ceRNAs), lead to an additional post-transcriptional regulatory layer, where non-coding RNAs can find new significance. The miRNA-mediated interplay among different types of RNA molecules has been observed in many different contexts. The analyses of ceRNA networks in cancer and other pathologies, as well as in other physiological conditions, provide new opportunities for interpreting omics data for the field of personalized medicine. The development of novel computational tools, providing putative predictions of ceRNA interactions, is a rapidly growing field of interest. In this review, I discuss and present the current knowledge of the ceRNA mechanism and its implications in a broad spectrum of different pathologies, such as cardiovascular or autoimmune diseases, cancers and neurodegenerative disorders.

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Section: Cerna and Diseasesmentioning

confidence: 99%

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

Ala

2020

Cells

127

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“…HOTAIR supports the stability of LRRK2 expression in PD, and its knockdown in MPP-treated SH-SY5Y cells conferred a protective effect against neuroinflammation [190]. HOTAIR promotes cell apoptosis by sponging miR-221 in in vitro and in vivo PD models [191]. These studies provide insights into the interplay between the diseased heart and brain and suggest that non-coding RNAs play a role in common pathways governing PD and heart diseases.…”

Section: Non-coding Rnas In the Brain-heart Axis In Pdmentioning

confidence: 68%

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

Acharya

Salgado-Somoza

Stefanizzi

et al. 2020

IJMS

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Parkinson’s disease (PD) is a complex and heterogeneous disorder involving multiple genetic and environmental influences. Although a wide range of PD risk factors and clinical markers for the symptomatic motor stage of the disease have been identified, there are still no reliable biomarkers available for the early pre-motor phase of PD and for predicting disease progression. High-throughput RNA-based biomarker profiling and modeling may provide a means to exploit the joint information content from a multitude of markers to derive diagnostic and prognostic signatures. In the field of PD biomarker research, currently, no clinically validated RNA-based biomarker models are available, but previous studies reported several significantly disease-associated changes in RNA abundances and activities in multiple human tissues and body fluids. Here, we review the current knowledge of the regulation and function of non-coding RNAs in PD, focusing on microRNAs, long non-coding RNAs, and circular RNAs. Since there is growing evidence for functional interactions between the heart and the brain, we discuss the benefits of studying the role of non-coding RNAs in organ interactions when deciphering the complex regulatory networks involved in PD progression. We finally review important concepts of harmonization and curation of high throughput datasets, and we discuss the potential of systems biomedicine to derive and evaluate RNA biomarker signatures from high-throughput expression data.

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