“…For example, Gm42418 was strongly downregulated in MNPQ compared to vehicle in all seven cell types. Gm42418 is a lncRNA and the role of these enigmatic transcripts in brain function, and in neurological disorders such as PD, is becoming more widely appreciated (Andersen and Lim, 2018;Taghizadeh et al, 2021). Other differentially expressed genes shared between at least two cell types included Actb, Acls3,Agt,Atp1b1,Btbd17,Camk2n1,Cmbl,Dbp,Fabp5,Fam23b,Id4,Igfbp2,Malat1,Mt2,Nnat,Ndufb5,Nap1l3,Prpf4b,Rgs22,Rps26,Rpl28,Slc6a11 and Tagln. Malat1 was downregulated by MNPQ in astrocytes and endothelial cells and is a lncRNA that appears to play a role in PD and other neurodegenerative disorders (Lu et al, 2020).…”