RETRACTED ARTICLE: Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury

Alzahrani, Sharifa; Ajwah, Sadeem M.; Alsharif, Sumayyah Yasser; Said, Eman; El‐Sherbiny, Mohamed; Zaitone, Sawsan A.; Al‐Shabrawey, Mohamed; Elsherbiny, Nehal M.

doi:10.1007/s00210-020-01948-5

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…Based on the above findings and ISO has been reported to improve oxidative stress (Alzahrani et al, 2020;G omez-Sierra, Medina-Campos, Solano, Ibarra-Rubio, & Pedraza-Chaverri, 2020) Consistent with these data, mice treated with ISO also displayed elevated expression of fatty acid oxidation-related proteins but reduced expression of proteins related to lipid synthesis (Figure 3F-H, Data S1). Taken together, these data demonstrate that ISO reduced intracellular lipid content by reducing lipid synthesis and increasing lipid oxidation processes.…”

Section: Iso Impeded Intracellular Lipid Content Via Pparα and Srebp1 Inductionsupporting

confidence: 81%

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Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Zhang

Yang

Qi-Li

et al. 2021

Phytotherapy Research

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Section: Iso Impeded Intracellular Lipid Content Via Pparα and Srebp1 Inductionsupporting

confidence: 81%

“…Based on the above findings and ISO has been reported to improve oxidative stress (Alzahrani et al, 2020; Gómez‐Sierra, Medina‐Campos, Solano, Ibarra‐Rubio, & Pedraza‐Chaverri, 2020), we next explored how ISO lowered lipid content in hepatocytes. First, we measured mitochondrial function using the Seahorse XF Cell Mito Stress Test kit.…”

Section: Resultsmentioning

confidence: 92%

Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Zhang

Yang

Qi-Li

et al. 2021

Phytotherapy Research

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“…DM-induced hepato-renal injury and the related pathologies were evident at 8 weeks post-DM induction, as confirmed through biochemical and histopathological assessments. The associations between oxidative status, inflammation, and apoptosis in DM and its associated complications have been previously demonstrated [ 15 , 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation

El-Sherbiny

El-Shafey

Said

et al. 2022

Life

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In this study, we aim to explore the beneficial therapeutic impacts of dapagliflozin (Dapa), a highly potent, reversible, and selective sodium–glucose cotransporter-2 inhibitor, and liraglutide (Lira), a glucagon-like peptide-1 (GLP-1) receptor agonist, as hypoglycaemic agents for the management of diabetes mellitus (DM), as well as their combination against DM-induced complications, including hepato-renal injury. Indeed, the progression of DM was found to be associated with significant hepatic and renal injury, as confirmed by the elevated biochemical indices of hepatic and renal functions, as well as histopathological examination. Dapa, Lira, and their combination effectively attenuated DM-induced hepatic and renal injury, as confirmed by the recovery of hepatic and renal functional biomarkers. The administration of both drugs significantly reduced the tissue contents of MDA and restored the contents of GSH and catalase activity. Moreover, NF-κB and TNF-α expression at the protein and gene levels was significantly reduced in the liver and the kidney. This was in parallel with the significant reduction in the caspase-3 content in the liver and the kidney, as well as suppressed cleaved caspase-3 expression in the hepatic and renal specimens, as confirmed by immune–histochemical analysis. Notably, the combined Dapa/Lira treatment demonstrated an additive superior hepato-renal protective impact compared with the use of either drug alone. Thus, it appears that Dapa and Lira, through the coordinated modulation of oxidative, inflammatory, and apoptotic signalling, confer a significant hepato-renal protective impact against DM-induced complications and tissue injury.

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“…Isoliquiritigenin blocked mesangial proliferation and matrix deposition during diabetic nephropathy by inactivating TGF- β RI and TGF- β RII and inhibiting the downstream SMAD signaling pathway [ 187 ]. STZ-induced diabetes was also alleviated by isoliquiritigenin via attenuation of oxidative stress, inflammation, and endothelial damage, downregulation of miR-195, restoration of retinal SIRT-1 levels, and tissue structure [ 150 ]. In addition, liquiritigenin significantly decreased high-fructose-diet-stimulated cardiac injury by mitigating tissue inflammation and fibrosis via suppression of the NF- κ B signaling pathway [ 189 ].…”

Section: Antidiabetic Effectmentioning

confidence: 99%

Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Glycyrrhizae Radix et Rhizoma is the most frequently prescribed natural medicine in China and has been used for more than 2,000 years. The flavonoids of licorice have garnered considerable attention in recent decades due to their structural diversity and myriad pharmacological effects, especially as novel therapeutic agents against inflammation and cancer. Although many articles have been published to summarize different pharmacological activities of licorice in recent years, the systematic summary for flavonoid components is not comprehensive. Therefore, in this review, we summarized the pharmacological and mechanistic data from recent researches on licorice flavonoids and their bioactive components.

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RETRACTED ARTICLE: Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury

Cited by 16 publications

References 38 publications

Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation

Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids

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