RETRACTED ARTICLE: Injectable hydrogel encapsulating Cu2MnS2 nanoplates for photothermal therapy against breast cancer

Abstract

BackgroundIn order to explore the possibility of treating breast cancer by local photo-therapy, a photothermal agents loaded in situ hydrogel was established. In detail, The Cu2MnS2 nanoplates were prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as the hydrogel matrix. The Cu2MnS2 nanoplates and the hydrogel were characterized by morphous, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation as well as the rheology features. The therapeutic effects of the Cu2MnS2 nanoplates and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention, photothermal efficacy, therapeutic effects and systemic toxicity of the hydrogel were assessed in tumor bearing mouse model.ResultsThe Cu2MnS2 nanoplates with a diameter of about 35 nm exhibited satisfying serum stability, photo-heat conversion ability and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanoplates loaded in situ hydrogel shows a phase transition at body temperature and, as a result, a long retention in vivo.ConclusionsThe photothermal agent embedded hydrogel played a promising photothermal therapeutic effects in tumor bearing mouse model with low systemic toxicity after peritumoral administration.

Hollow Cu2Se Nanozymes for Tumor Photothermal-Catalytic Therapy

“…It has been reported that Cu + -catalyzed Fenton-like has high efficiency in neutral and weakly acidic conditions, and the reaction rate can reach∼160-fold higher than that of Fe 2+ /Fe 3+ . However, copper-based nanomaterials used for CDT of cancer had been seldom reported except the recent self-assembled copper-amino acid nanoparticles. , In addition, copper-based nanomaterials have become one of the research hot-spots because of their strong absorption in the NIR region, good biocompatibility, and excellent photothermal conversion efficiency . Compared with other copper-based materials, Cu 2 Se nanomaterials are particularly interesting not only because they have similar optical absorption in NIR window and great photothermal performance but also owing to the fact that Cu and Se are important trace elements in the human body. , Herein, Cu 2 Se hollow nanocubes (Cu 2 Se HNCs) with strong NIR II absorbance were explored for PTT–CDT synergistic therapy of cancer.…”

Construction of tissue-customized hydrogels from cross-linkable materials for effective tissue regeneration

“…For example, Cu 2+ -based hydrogels can be used for cancer therapy due to their cellular toxicity to cancerous cells. 123,124 Therefore, choosing appropriate cation-crosslinkers and suitable doses are necessary. For example, in hydrogels, a maximum Cu concentration of 6.8 mg kg −1 shows no toxic effects on fibroblasts and is considered tolerable for tissue regeneration.…”

Retraction Note to: Injectable hydrogel encapsulating Cu2MnS2 nanoplates for photothermal therapy against breast cancer

“…The authors have retracted this article [ 1 ] because of an error in the methodology. Recently, the authors have tested the Cu2MnS2 nanoparticles used in their study by XRD, XPS and TEM mapping and have found that the manganese element was not successfully doped.…”

“…The original article can be found online at https ://doi.org/10.1186/s1295 1-018-0409-3. *Correspondence: liuchengchengf1@163.com 1 Department of Medical Oncology, The Fifth Affiliated Hospital of Guang-Zhou Medical University, Guangzhou Medical University, Guangzhou 510700, China Full list of author information is available at the end of the article…”