RETRACTED ARTICLE: Improved pregnancy outcome following earlier splenectomy in women with immune thrombocytopenia: a 5-year observational study

Rezk, Mohamed; Masood, Alaa; Dawood, Ragab; Emara, Mahmoud; Elsayed, Hanan

doi:10.1080/14767058.2017.1344636

Cited by 12 publications

(13 citation statements)

References 12 publications

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“…The remaining 163 papers were carefully examined, leading us to exclude 148 of them for a variety of reasons, of which following a retrospective design was by far the most common (n=105). The final selection comprised 15 articles (n=1,043 pregnancies) (Figure 1) (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Table S1 depicts the chosen studies and includes information concerning their aims and the topics addressed.…”

Section: Resultsmentioning

confidence: 99%

Bleeding Complications Associated with Pregnancy with Primary Immune Thrombocytopenia: A Meta-Analysis

González‐Porras

Palomino

Vaquero‐Roncero

et al. 2022

TH Open

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Introduction: Immune thrombocytopenia (ITP) during pregnancy has received little attention from researchers. Reliable information about the outcome of mothers and newborns is required to properly counsel women who are pregnant or planning to become pregnant. Our primary outcomes were the frequency and severity of maternal and neonatal bleeding events in the setting of ITP in pregnancy. Mode of delivery, neonatal thrombocytopenia and maternal / infant mortality were secondary outcomes. Material and Methods: We comprehensively reviewed the prospective studies that enrolled ≥20 pregnant women with primary ITP. Two reviewers, blinded to each other, searched Medline and Embase up to February 2021. Meta-analyses of the maternal and newborn outcomes were performed. Overall weighted proportions were estimated by a random effects model. Results: From an initial screening of 163 articles, 15 were included, encompassing 1,043 pregnancies. The weighted event rate for bleeding during pregnancy was 0.181 (95% confidence interval [CI], 0.048 – 0.494). Most of these were non-severe cases. The weighted event rates were 0.053 (95% CI, 0.020 – 0.134) for severe postpartum hemorrhage, 0.014 (95% CI, 0.008 – 0.025) for intracerebral hemorrhage and 0.122 (0.095 – 0.157) for severe thrombocytopenia events in neonates (platelet count <50,000/L). There were no reliable predictors of severe neonatal thrombocytopenia. The incidence of neonatal mortality was 1.06%. There were no maternal deaths. Conclusion: Primary ITP in pregnant women is rarely associated with poor outcomes.

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Section: Resultsmentioning

confidence: 99%

Bleeding Complications Associated with Pregnancy with Primary Immune Thrombocytopenia: A Meta-Analysis

González‐Porras

Palomino

Vaquero‐Roncero

et al. 2022

TH Open

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“…After applying inclusion criteria, 21 studies remained-all of which were retrospective cohort studies. 18,[21][22][23][24][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The extracted data from these studies are summarized in detail in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The 21 studies contained data from a total of 1951 mothers and 1844 infants, including 375 infants suffering from thrombocytopenia. The average maternal age, as calculated from the 11 studies that reported this information, 21,22,24,34,36,[38][39][40]42,43,47 was 27.7 AE 2.8 years.…”

Section: Participant Informationmentioning

confidence: 99%

“…Neonatal thrombocytopenia overall incidence was assessed in all of the 21 included studies. 18,[21][22][23][24]31,[33][34][35][36][37][38][39][40][41][42][43][44][45]47 The overall event rate of all thrombocytopenia was found to be (Figure 4) 24% (95% CI = 16.7%-33.1%, p < 0.01) presenting negligible heterogeneity (I 2 : 15.3%).…”

Section: Incidence Of Thrombocytopeniamentioning

confidence: 99%

“…Hemorrhage prevalence was assessed in 14 included studies. 18,21,22,[31][32][33][34][36][37][38]40,43,44,46 The overall prevalence of hemorrhage was found to be (Figure 8) 4.1% (95% CI = 1.6%-9.9%, p < 0.01) presenting no heterogeneity (I 2 : 0%).…”

Section: Prevalence Of Hemorrhagementioning

confidence: 99%

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A meta‐analysis of neonatal outcomes in pregnant women with immune thrombocytopenic purpura

Luo

Gao

et al. 2021

J of Obstet and Gynaecol

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Aim: Thrombocytopenia is an autoimmune disorder characterized by reduced platelet counts. Neonatal thrombocytopenia incidence has been linked with immune thrombocytopenic purpura in mothers during pregnancy, possibly because antiplatelet antibodies can cross the placental barrier. To date, no study has attempted to evaluate the actual prevalence of neonatal thrombocytopenia in infants born to mothers with immune thrombocytopenic purpura. In this meta-analysis of the available literature, we attempt to fill this gap. We want to evaluate the overall prevalence of neonatal thrombocytopenia, its severity, and the incidence of hemorrhage in infants with thrombocytopenia born from mothers with immune thrombocytopenic purpura. Methods: Adhering to PRISMA guidelines, we systematically scanned four academic databases including EMBASE, CENTRAL, Scopus, and MEDLINE to identify relevant literature. We performed a meta-analysis to summarize thrombocytopenia incidence rate and severity in newborn infants of mothers with immune thrombocytopenic purpura. Results: We identified 21 eligible studies involving 1951 mothers and 1844 neonates. Meta-analysis showed high prevalence for neonatal thrombocytopenia (24%). Within these, severe cases were the most prevalent (41.2%), followed by moderate (37.7%) and mild (17.6%) cases. Hemorrhage was only reported in 4.1% of the observed neonatal thrombocytopenia cases. Conclusion:This review provides preliminary evidence that neonatal thrombocytopenia incidence is high in infants born to mothers with immune thrombocytopenic purpura. This study further reports that the largest proportion of these cases are severe.

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Prophylactic Splenectomy

Bayramov

Mammadov

Gahramanova

2021

Prophylactic Surgery

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RETRACTED ARTICLE: Improved pregnancy outcome following earlier splenectomy in women with immune thrombocytopenia: a 5-year observational study

Abstract: Earlier splenectomy in patients with ITP may have a beneficial impact on obstetric outcome and should be explained to patients wishing to get pregnant. Further larger multicenter studies are warranted to confirm or refute our findings.

Cited by 12 publications

References 12 publications

Bleeding Complications Associated with Pregnancy with Primary Immune Thrombocytopenia: A Meta-Analysis

Bleeding Complications Associated with Pregnancy with Primary Immune Thrombocytopenia: A Meta-Analysis

A meta‐analysis of neonatal outcomes in pregnant women with immune thrombocytopenic purpura

Prophylactic Splenectomy

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