RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN

Wang, Bin; Wu, Zhisheng; Lou, Ping Yang; Chai, Chang; Han, Shuang; Ning, Jian; Li, Ming

doi:10.1007/s13402-019-00461-z

Cited by 43 publications

(35 citation statements)

References 44 publications

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“…1). В частности, имеются указания на стимулирующие регенерацию эффекты при ишемическом и ишемическом/реперфузионном повреждении клеток миокарда [2][3][4][5][6][7][8][9][10][11][12], на противоопухолевую эффективность внутриклеточных везикул [13][14][15][16][17], а также эффективность при терапии осложнений сахарного диабета [18][19][20]. Имеются данные о проостеогенном потенциале внутриклеточных везикул, что может найти применение при замещении костных дефектов [21][22][23][24].…”

Section: потенциальные цели терапевтического применения ввunclassified

“…На клетках гепатоцеллюлярной карциномы [15], глиобластомы [13,15], глиомы [14], а также аденокарциномы [17], показано, что ВВ способны переносить агенты, подавляющие рост и инвазивность клеток опухолей. Таковыми являются: микроРНК-335-5p [15], микроРНК-34a [13], мик -роРНК-145-5p (сайленсинг Smad3) [17], микроРНК-145, микроРНК-200b и микроРНК-200c [16]. Добавление везикул к клеточным линиям глиобластомы увеличивало их чувствительность к темозоломиду, т. к. он действует на фракцию покоящихся клеток [13].…”

Section: таблица 1 продолжениеunclassified

“…Таковыми являются: микроРНК-335-5p [15], микроРНК-34a [13], мик -роРНК-145-5p (сайленсинг Smad3) [17], микроРНК-145, микроРНК-200b и микроРНК-200c [16]. Добавление везикул к клеточным линиям глиобластомы увеличивало их чувствительность к темозоломиду, т. к. он действует на фракцию покоящихся клеток [13].…”

Section: таблица 1 продолжениеunclassified

“…При эксперименте с глиобластомой выявлены дополнительные эффекты -везикулы, нагруженные микроРНК-34a, увеличивали чувствительность клеток опухоли к химиопрепаратам [13]. Это может быть связано как с сайленсингом онкогена MYCN, так и с уменьшением пролиферации клеток опухолипротив таких клеток наиболее эффективен применявшийся темозоламид.…”

Section: In Vivo исследованияunclassified

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Extracellular vesicles therapy: opportunities, mechanisms and perspectives

Великонивцев¹,

Головкин²

2020

Russ J Cardiol

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Extracellular vesicles are biological membrane-coated objects with size less then 1000 nm. They can contain variety of biologically active molecules (such as proteins, miRNA, mRNA, DNA etc.) and also are able to provide intercellular communications and implement lots if biological functions. Now possibilities of using extracellular vesicles for therapeutic approaches against various diseases and pathological conditions are rapidly discovered. In the most of cases mesenchymal stem cells are the sources of extracellular vesicles and miRNAs which vesicles transport are considered to be causable agents of their activities. In-vitro studies show that extracellular vesicles provide anti-inflammatory, anti-apoptotic activities and can stimulate angiogenesis and regeneration. Performed studies which were analyzed and structurized by us in this review demonstrate current perspectives for clinical use of extracellular vesicles in the therapy of such clinical conditions as oxidative stress, ischemia-reperfusion injury, tumor growth etc.

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Section: потенциальные цели терапевтического применения ввunclassified

Section: таблица 1 продолжениеunclassified

Section: In Vivo исследованияunclassified

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Extracellular vesicles therapy: opportunities, mechanisms and perspectives

Великонивцев¹,

Головкин²

2020

Russ J Cardiol

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“…25 Notably, MYCN is a direct target of miR-34a and MYCN overexpression could ameliorate GBM development. 26 However, its relationship with miR-449b-5p in GBM has not explored.…”

Section: Introductionmentioning

confidence: 99%

SNHG7 Facilitates Glioblastoma Progression by Functioning as a Molecular Sponge for MicroRNA-449b-5p and Thereby Increasing MYCN Expression

Chen

Yuan

Ning

et al. 2020

Technol Cancer Res Treat

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Background and Aims: Long noncoding RNA (small nucleolar RNA host gene 7) has been reported to be involved in multiple malignancies and acts as an oncogene. However, the potential mechanism of small nucleolar RNA host gene 7 in glioblastoma is rarely known. In this study, we attempted to elucidate the biological effects of small nucleolar RNA host gene 7 and the possible molecular mechanism in glioblastoma. Methods: The expression level of small nucleolar RNA host gene 7 in glioblastoma tissues and corresponding tumor cell lines was evaluated by using quantitative real-time polymerase chain reaction. Bioinformatics analyses and dual-luciferase reporter gene assay were conducted to verify the correlation among small nucleolar RNA host gene 7, miR-449b-5p, and MYCN. The role of small nucleolar RNA host gene 7 on cell viability, migration, and invasion was measured. Results: Small nucleolar RNA host gene 7 expression was markedly increased in glioblastoma tumor tissue. Small nucleolar RNA host gene 7 can sponge miR-449b-5p and negatively regulate miR-449b-5p expression. MiR-449b-5p was remarkably repressed in glioblastoma tissues. Reduction of miR-449b-5p reversed the repressive effects of small nucleolar RNA host gene 7 knockdown on cellular behaviors in glioblastoma. In addition, miR-449b-5p can directly bind with MYCN. Compared with normal samples, MYCN expression was increased. The MYCN expression was negatively related to miR-449b-5p expression while positively related to small nucleolar RNA host gene 7 expression. Rescue experiments revealed that MYCN overexpression reversed the repressive role of small nucleolar RNA host gene 7 knockdown on viability, migration, and invasion of U251 cells. Conclusion: In summary, our results demonstrated that small nucleolar RNA host gene 7 regulates glioblastoma proliferation, migration, and invasion via regulating miR-449b-5p and its target gene MYCN, thereby providing a potential therapeutic target for glioblastoma.

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Cancer Biomarkers in Body Fluids

Dakubo

2019

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RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN

Cited by 43 publications

References 44 publications

Extracellular vesicles therapy: opportunities, mechanisms and perspectives

Extracellular vesicles therapy: opportunities, mechanisms and perspectives

SNHG7 Facilitates Glioblastoma Progression by Functioning as a Molecular Sponge for MicroRNA-449b-5p and Thereby Increasing MYCN Expression

Cancer Biomarkers in Body Fluids

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