RETRACTED ARTICLE: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet

Abstract

BackgroundHypercholesterolemia is associated with an increased risk of heart disease. In this study, we investigated the antihyperlipidemic effects of garlic (Allium sativum L.) in rat models of hypercholesterolemic.MethodsWistar male rats were randomly divided into 4 diet groups with garlic supplementation. Male Wistar rats were fed by standard pellet diet (group I), standard diet supplemented with 4 % garlic (group II), lipogenic diet (containing sunflower oil, cholesterol and ethanol) equivalent to 200 mg raw garlic/kg body weight (raw) (group III) and lipogenic diet equivalent to 400 mg raw garlic/kg body weight (raw) (group IV).ResultsRats fed 400 g/kg garlic extract(GE), had a significantly lower concentration of serum low-density lipoprotein cholesterol (LDL-C) cholesterol and elevated HDL –C cholesterol at day 28 (P < 0.05).In addition,serum levels of LDL-C was lower in the III and IV group than those in the IV group (P < 0.001 for each). However, cholesterol efflux capacity was positively correlated with HDL cholesterol concentration (P < 0 · 0001). It was also directly correlated with garlic supplementation (P < 0 · 0001).ConclusionTogether Taken, the results are clearly indicative of the beneficial effects of garlic in reducing lateral side effects of hyperlipidemia. Our data demonstrate that GE has protective effects on HDL in rats with high LDL intake. Therefore, it could be used to remedy hypercholesterolemia with help reduce risk of coronary heart diseaseVirtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1834155749171141

Retraction Note: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet

“…The Editor-in-Chief and Publisher have retracted this article [1] because the scientific integrity of the content cannot be guaranteed. An investigation by the Publisher found it to be one of a group of articles we have identified as showing evidence suggestive of attempts to subvert the peer review and publication system to inappropriately obtain or allocate authorship.…”

Effect of Allium Sativum Essential Oil on the Glycemic Control and Hyperlipidemia in Type 2 Diabetes Mellitus Subjects

“…[8,9] Efficacy of AS as antihyperlipidemic agent has been debated owing to diverging views of previous studies [10][11][12][13][14][15] in the CAD and PAD. However, recently published studies [10][11][12] have reported positive efficacy of AS against the CAD by cutting down the elevated blood cholesterol and lipids. Data from developing countries is lacking although AS is frequently used as food additive even in Pakistan.…”

“…Data from developing countries is lacking although AS is frequently used as food additive even in Pakistan. [11,13] Previous studies [13,14] had applauded its anti-hypertensive effects of ASE. A previous study [15] reported that the AS essential oil (ASEO) was effective in mobilizing the fat from fatty liver.…”

“…[32,33] Interventional studies have similarly shown anti hyperlipidemic effects of total plasma lipids in humans. [34][35][36] The strength of study lies in its participants who showed regular follow ups, regular use of drug and prospective study design. Side effects of ASEO were not observed in the present study.…”

“…ASEO has anti hyperlipidemic effects, is proved in the present similar to previously reported studies. [11][12][13][14] The ASEO may be prescribed for the prevention of atherogenesis in its earlier stages. How the ASE reduces LDLc and increases HDLc.…”