RETRACTED ARTICLE: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Zhang, Haiyang; Deng, Ting; Ge, Shaohua; Liu, Ying; Bai, Ming; Zhu, Kegan; Fan, Qian; Li, Jialu; Ning, Tao; Tian, Fei; Liu, Hongli; Sun, Wei; Ying, Guoguang; Ba, Yi

doi:10.1038/s41388-018-0619-z

Cited by 271 publications

(217 citation statements)

References 39 publications

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“…Notably, regarding the role of exosomal circRNA in cancer, exosomes containing circRNAs may function to promote or inhibit cancer progression. Exosomal circRNAs promote the progression (proliferation and invasiveness) of cancer, the generation of premetastatic niches and the occurrence of metastasis (33,34). By contrast, exosomal circRNAs also regulate tumour immunity and immunotherapy and play a role in cancer treatment (35,36).…”

Section: Exosomal Circular Rna Sorting Mechanisms and Their Functionmentioning

confidence: 99%

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

et al. 2020

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Exosomes are nanoscale phospholipid bilayer vesicles that can be artificially engineered into vectors for the treatment of cancer. Circular RNA (circRNA), a type of non-coding RNA, has crucial regulatory functions in various aspects of cancer, such as tumorigenesis, apoptosis, proliferation, invasion, metastasis and chemo-and radiotherapeutic resistance, as well as in cancer prognosis. Notably, the exosomal transfer of circRNAs may function to both promote and inhibit cancer. Numerous studies have addressed the importance of circRNAs in cancer and non-coding RNAs (such as microRNAs and long non-coding RNAs) in exosomes. However, little research has focussed on a class of RNAs called exosomal circRNAs. The present review discusses current studies regarding exosomal circRNAs, including their biogenesis and biological functions, their abundance in exosomes and possible sorting mechanisms and their potential roles in both promoting and inhibiting cancer. It is predicted that in the next five years there will be increasing research exploring the functional mechanisms of exosomal circRNA in various diseases, in particular their roles in cancer genesis and progression.

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Section: Exosomal Circular Rna Sorting Mechanisms and Their Functionmentioning

confidence: 99%

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

et al. 2020

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“…Increasing studies have verified that circRNAs can exert their functions by acting as ceRNAs to sponge miRNAs [16][17][18]. Considering the cytoplasmic localization of circFMN2 in CRC cells, we investigated whether circFMN2 exerted function in CRC in an miRNA-mRNA-dependent manner.…”

Section: Circfmn2 Promoted Crc Progression By Sponging Mir-1182mentioning

confidence: 99%

“…It has been well established that exosomes originate from multivesicular endosomes (multivesicular bodies) by inverse budding to form multivesicular bodies, and are released into the extracellular space when the multivesicular body fuses with cell membrane exosomes [17]. Exosomes can regulate the physiological and pathological functions of various cancers as message transmitters in intercellular communication because they contain a variety of proteins, lipids, circRNAs, and microRNAs [18]. Recent studies have demonstrated that circRNAs are abundant and stable in exosomes, however, there is little evidence for the expression profile and potential function of secreted circRNAs in CRC.…”

Section: Introductionmentioning

confidence: 99%

A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways

Chang-feng

et al. 2019

Clinical Science

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Background: Circular RNAs (circRNAs) are a class of non-coding RNAs broadly expressed in cells of various species. However, the molecular mechanisms that link circRNAs with colorectal cancer (CRC) are not well understood. In the present study, we attempted to provide novel basis for targeted therapy for CRC from the aspect of circRNA–microRNA (miRNA)–mRNA interaction. Methods: We investigated the expression of circRNAs in five paired CRC tissues and adjacent non-tumor tissues by microarray analysis. Differentially expressed circRNAs were identified between CRC tissues and non-cancerous matched tissues. We focused on hsa_circ_0005100, which is located on chromosome 1 and derived from FMN2, and thus we named it as circFMN2. The expression of circFMN2 was detected in 88 CRC tissues and cell lines by quantitative real-time PCR. Functional assays were performed to evaluate the effects of circFMN2 on proliferation in vitro, and on tumorigenesis in vivo. The relationship between circFMN2 and miR-1182 was confirmed by luciferase reporter assay. Results: circFMN2 was found to be significantly up-regulated in CRC tissues and cell lines. Moreover, knockdown of circFMN2 significantly inhibited cell proliferation and migration in vitro. Bioinformatics analysis predicted that there is a circFMN2/miR-1182/hTERT axis in CRC progression. Dual-luciferase reporter system validated the direct interaction of circFMN2, miR-1182, hTERT. Western blot verified that inhibition of circFMN2 decreased hTERT expression. Importantly, we demonstrated that circFMN2 was up-regulated in serum exosomes from CRC patients. Conclusion: In conclusion, circFMN2 is a central component linking circRNAs to progression of CRC via an miR-1182/hTERT axis.

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“…Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme and a high level of USP7 is frequently found in HCC tissues. circ-DB absorbs miR-34a, which targets USP7 mRNA and promotes the expression of USP7 (Zhang et al, 2019a). Interestingly, exosomal circRNAs derived from gastric cancer (GC) cells also function as sponges for miRNA.…”

Section: Regulations Of Circrnas Circrnas In Exosomesmentioning

confidence: 99%

Structure, Regulation, and Function of Linear and Circular Long Non-Coding RNAs

Qin

Zhang

2020

Front. Genet.

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Long non-coding RNAs (lncRNAs), including linear lncRNAs and circular RNAs (circRNAs), exhibit a surprising range of structures. Linear lncRNAs and circRNAs are generated by different pathways. Linear lncRNAs perform functions that depend on their specific sequences, transcription, and DNA elements of their gene loci. In some cases, linear lncRNAs contain a short open reading frame encoding a peptide. circRNAs are covalently closed RNAs with tissue-specific and cell-specific expression patterns that have recently been extensively investigated. Pioneering work focusing on their biogenesis and functional characterization indicates that circRNAs regulate cell development via multiple mechanisms and play critical roles in the immune system. Furthermore, circRNAs in exosomes function on target cells. As with linear lncRNAs, specific circRNAs can also be translated. In this review, we summarize current understanding and highlight the diverse structure, regulation, and function of linear lncRNAs and circRNAs.

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RETRACTED ARTICLE: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Cited by 271 publications

References 39 publications

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways

Structure, Regulation, and Function of Linear and Circular Long Non-Coding RNAs

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