RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

Abstract

BackgroundSquamous cell carcinomas (SCCs) are uncommon, high-grade tumors, predominantly composed of round cells in the prepuce. The aim of this study is to better define the clinicopathologic features of this neoplasm.Case reportWe conducted cyto-histopathologic analysis on the manifestations of the prepuce SCC by H & E staining in a terrier mix dog. Grossly, tumor was large, multiple erythematous patch, and ulcerated masses frequently affecting the prepuce and deeply invading to distal prepuce out from the ventro-lateral of penis and the tumor covered by a necrotic discharge. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the prepuce comprised of round nuclei, coarse chromatin pattern, distinct nucleoli and nuclear pleomorphism. Furthermore, the neoplastic cells were pleomorphic, round to caudate in shape, exhibiting prominent anisokaryosis and anisocytosis with rare mitotic features. Microscopically, the lesions were predominantly composed of atypical round cells disposed in interlacing fascicles. Frequent findings include keratin formation, horn pearls, mitoses and cellular atypia. The cells showed distinct borders, ranged from polygonal to round or elongate and had moderate amounts of eosinophilic cytoplasm.ConclusionThe histopathologic features coupled with the cytopathology findings led to a diagnosis of squamous cell carcinoma. To the authors’ knowledge, this is the first time that multiple erythematous plaques have undergone malignant transformation in a terrier mix dog.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5748771971272873

Management of squamous cell carcinoma on the thigh of a Nigerian Albino horse

“…In the present case, the histopathological features observed were focal areas of keratin (keratin pearls), concentric aggregation of cornified squamous epithelial cells (horn pearl), massive undifferentiated tumour cells at different stages of mitosis (anisocytosis and anisokaryosis) and presence of inflammatory cells (Plate II). These are typical findings in metastatic tumour of squamous cells in horses as described for preputial sheath SCC case in mixed breed dog by Manesh et al (2014). This, therefore, confirms the diagnosis of SCC.…”

Retraction note: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

“…The Editor-in-Chief and Publisher have retracted this article [1] because the scientific integrity of the content cannot be guaranteed. An investigation by the Publisher found it to be one of a group of articles we have identified as showing evidence suggestive of attempts to subvert the peer review and publication system to inappropriately obtain or allocate authorship.…”

Tubular adenocarcinoma with squamous differentiation areas in a feline foreskin (Felis catus): A report of clinical-surgical, pathological, and therapeutic approach

“…However, there are reports of adenocarcinoma affecting the feline mammary glands (Amorim et al, 2004), intestine (Queiroz et al, 2017), apocrine/salivary glands (Fujiwara-Igarashi et al, 2017), prostate (Tursi et al, 2008), and uterus (Saraiva et al, 2015). In addition, there are also reports of neoplasms affecting the foreskin of dogs (Yaghoobi Yeganeh Manesh et al, 2014;Auler et al, 2014) and horses (Chacur et al, 2014).…”

“…Cytology is a fast, relatively inexpensive, and non-invasive diagnostic examination, but only some types of tumors, such as lipomas and melanomas, can be diagnosed cytological analysis without any other methodologies (Alencar & Campos, 2017). Histopathological examination is essential to establish a definitive diagnosis and provide information regarding the extent of the neoplasia in deeper tissues (Yaghoobi Yeganeh Manesh et al, 2014).…”