RETRACTED ARTICLE: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model

Lu, Jiafeng; Xue, Ying; Wang, Yuhang; Ding, Yang; Zou, Qinyan; Pan, Min; Qiao, Longwei; Zhang, Chunhua; Ge, Qinyu; Wang, Ting; Li, Hong

doi:10.1007/s00441-020-03187-9

Cited by 17 publications

(12 citation statements)

References 36 publications

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“…The function of ciRs-126 has only been studied in acute kidney injury and polycystic ovarian syndrome[ 13 , 15 ]. It was observed that ciRs-126 was significantly overexpressed in patients with acute kidney injury and could sponge miR-126-5p to participate in disease progression[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…It was observed that ciRs-126 was significantly overexpressed in patients with acute kidney injury and could sponge miR-126-5p to participate in disease progression[ 13 ]. In polycystic ovarian syndrome, ciRs-126 is downregulated and targets miR-21-PDCD4-ROS axis to suppress ovarian granulosa cell proliferation[ 15 ]. This study, for the first time, reported the upregulation of ciRs-126 in H/R.…”

Section: Discussionmentioning

confidence: 99%

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Circular RNA ciRs-126 promotes hypoxia/reoxygenation cardiac injury possibly through miR-21

Tan

Yuan

et al. 2022

Thrombosis J

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Background This study aimed to analyze the role of circular RNA ciRs-126 in hypoxia/reoxygenation cardiac injury (H/R). Methods Expression of ciRs-126 and miR-21 in plasma samples from patients with H/R and healthy controls was determined by RT-qPCR. Correlations were analyzed by linear regression. Overexpression of ciRs-126 and miR-21 was achieved in cardiomyocytes to explore their crosstalk. The roles of ciRs-126 and miR-21 in H/R-induced apoptosis of cardiomyocytes were analyzed using cell apoptosis assay. Results CiRs-126 was upregulated and miR-21 was downregulated in H/R patients. They were inversely correlated across plasma samples from H/R patients. In H/R cardiomyocytes, ciRs-126 was upregulated and miR-21 was downregulated. In cardiomyocytes, ciRs-126 overexpression decreased miR-21 level and reduced the inhibitory effects of miR-21 overexpression on H/R-induced cell apoptosis. Conclusions Circular RNA ciRs-126 may suppress miR-21 expression to promote H/R cardiac injury.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Circular RNA ciRs-126 promotes hypoxia/reoxygenation cardiac injury possibly through miR-21

Tan

Yuan

et al. 2022

Thrombosis J

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“…In the study of Liu et al, overexpression of circPSMC3 was proved to decrease the insulin release and increase the number of granulosa cells in PCOS model mice by sponging miR-296-3p and then regulating PTEN expression. 18 Additionally, in vitro studies implied ciRS-126 19 and circASPH 20 regulated the proliferation and apoptosis of ovarian granulosa cells by targeting the miR-21-programmed cell death 4-reactive oxygen species and miR-375/mitogen-activated protein kinase kinase 6 axis, respectively. However, PCOS-associated circRNAs remain rarely reported.…”

Section: Introductionmentioning

confidence: 99%

WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs

Li¹,

Zeng²,

Zhang³

et al. 2021

IJGM

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“…CircRNA expression profiles have been studied in detail in PCOS (Che et al, 2019;Wang et al, 2019;. Lu et al (2020) found that CiRS-126 acts as a sponge for miR-21 to inhibit ovarian granulosa cell viability. Deng et al (2020) reported that circPUM1 regulates PCOS development by interacting with miR-760.…”

Section: Introductionmentioning

confidence: 99%

SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells

Duan¹,

Cai²,

Huang³

et al. 2021

Front. Genet.

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Polycystic ovary syndrome (PCOS), one of the most common types of endocrine diseases, is characterized by a high prevalence among women of reproductive-age. However, its pathogenesis and molecular mechanisms remain unclear. CircMTO1 has been reported to participate in numerous biological processes, but, its role in PCOS progression remains unknown. In the current study, we elucidated the expression and circRNA characterization of circMTO1 in human granulosa-like tumor cells. We found that circMTO1 knockdown promoted human granulosa-like tumor cell proliferation and inhibited its apoptosis rate. Next, we explored the underlying molecular mechanisms by using a series of experiments. Our results revealed the effect of the novel circMTO1/miR-320b/MCL1 axis in human granulosa-like tumor cells. Furthermore, we found that the expression of circMTO1 was induced by Snail family transcriptional repressor 2 (SNAI2) in human granulosa-like tumor cells. Our results may provide potential targets for PCOS research and a novel direction for the diagnosis and treatment of PCOS.

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RETRACTED ARTICLE: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model

Cited by 17 publications

References 36 publications

Circular RNA ciRs-126 promotes hypoxia/reoxygenation cardiac injury possibly through miR-21

Circular RNA ciRs-126 promotes hypoxia/reoxygenation cardiac injury possibly through miR-21

WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs

SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells

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