SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells

Duan, Jie; Cai, Hongning; Huang, Yanming; Shi, Liangyan

doi:10.3389/fgene.2021.689916

Cited by 4 publications

(2 citation statements)

References 49 publications

(47 reference statements)

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“…Further investigations confirmed that circPSMC3 exerted its function by sponging miR-296-3p to regulate PTEN expression. CircMTO1 significantly influenced proliferation and apoptosis rate of GCs through miR-320b, which directly targeted MCL1 in PCOS [55]. Similarly, the expression of circ_RANBP9 was closely associated with GC proliferation and apoptosis; subsequent studies revealed that circ_RANBP9 functioned via the miR-136-5p/XIAP axis in PCOS [56].…”

Section: Circular Rnas and Ovarian Dysfunction In Pcosmentioning

confidence: 94%

Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome

Jing,

Wu,

Wan

et al. 2023

Biomolecules

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Polycystic ovary syndrome (PCOS) is a prevalent metabolic and reproductive disorder that causes low fertility in females. Despite its detrimental effects on women’s health, care for PCOS has been impeded by its undefined pathogenesis. Thus, there is an urgent need to explore novel biomarkers and therapeutic targets for the diagnosis and treatment of PCOS. Circular RNAs (circRNAs) are a class of noncoding RNAs with covalently closed cyclic structures, present in high abundance, and show development-stage specific expression patterns. Recent studies have demonstrated that circRNAs participate in PCOS progression by modulating various biological functions, including cell proliferation, apoptosis, and steroidogenesis. In addition, circRNAs are widely present in the follicular fluid of women with PCOS, indicating their potential as diagnostic biomarkers and therapeutic targets for PCOS. This review provides the current knowledge of circRNAs in PCOS, including their regulatory functions and molecular mechanisms, and explores their potential as diagnostic biomarkers and therapeutic targets.

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Section: Circular Rnas and Ovarian Dysfunction In Pcosmentioning

confidence: 94%

Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome

Jing,

Wu,

Wan

et al. 2023

Biomolecules

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“…CircMTO1 was found to mediate the progression of human granulosa-like tumor cells through the miR-320b/MCL1 axis, promoted by increased transcription of SNAI2. Thus, Duan et al concluded that a SNAI2/circMTO1/miR-320b/MCL1 axis is a promoter of human granulosa-like tumor cells in PCOS [108].…”

Section: Role In Pcos Referencesmentioning

confidence: 99%

The Role of MicroRNA, Long Non-Coding RNA and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review

Nasser,

Altahoo,

Almosawi

et al. 2024

IJMS

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Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disease in females of reproductive age, affecting 4–20% of pre-menopausal women worldwide. MicroRNAs (miRNAs) are endogenous, single-stranded, non-coding, regulatory ribonucleic acid molecules found in eukaryotic cells. Abnormal miRNA expression has been associated with several diseases and could possibly explain their underlying pathophysiology. MiRNAs have been extensively studied for their potential diagnostic, prognostic, and therapeutic uses in many diseases, such as type 2 diabetes, obesity, cardiovascular disease, PCOS, and endometriosis. In women with PCOS, miRNAs were found to be abnormally expressed in theca cells, follicular fluid, granulosa cells, peripheral blood leukocytes, serum, and adipose tissue when compared to those without PCOS, making miRNAs a useful potential biomarker for the disease. Key pathways involved in PCOS, such as folliculogenesis, steroidogenesis, and cellular adhesion, are regulated by miRNA. This also highlights their importance as potential prognostic markers. In addition, recent evidence suggests a role for miRNAs in regulating the circadian rhythm (CR). CR is crucial for regulating reproduction through the various functions of the hypothalamic-pituitary-gonadal (HPG) axis and the ovaries. A disordered CR affects reproductive outcomes by inducing insulin resistance, oxidative stress, and systemic inflammation. Moreover, miRNAs were demonstrated to interact with lncRNA and circRNAs, which are thought to play a role in the pathogenesis of PCOS. This review discusses what is currently understood about miRNAs in PCOS, the cellular pathways involved, and their potential role as biomarkers and therapeutic targets.

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Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome

Ahmadi,

Fathi,

Malmir

et al. 2024

Mol Biol Rep

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SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells

Cited by 4 publications

References 49 publications

Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome

Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome

The Role of MicroRNA, Long Non-Coding RNA and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review

Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome

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