RETRACTED ARTICLE: Autism-like symptoms by exposure to air pollution and valproic acid–induced in male rats

Imam, Bahran; Rahmatinia, Masoumeh; Shahsavani, Abbas; Khodagholi, Fariba; Hopke, Philip K.; Bazazzpour, Shahriyar; Hadei, Mostafa; Yarahmadi, Maryam; Abdollahifar, Mohammad‐Amin; Torkmahalleh, Mehdi Amouei; Kermani, Majid; Ilkhani, Saba; Mirbehbahani, Seyed Hamidreza

doi:10.1007/s11356-022-19865-w

Cited by 3 publications

(3 citation statements)

References 107 publications

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“…66 As shown in Figure 5, our results demonstrated the impact of the "OXTR-PKMξ" pathway on LTP/synaptic plasticity. Consistent with other studies, 37,67,68 the decreased levels of OXTR in a mouse model in this study supported the association between OXTR and autism. Furthermore, exposure to lowdose O 3 has exacerbated this downward trend, suggesting the function of environmentally relevant air pollutants on the severity of autism.…”

Section: Aggravated Phenotypes In a Mouse Model Of Autism Under Chron...supporting

confidence: 93%

“…Previous studies have investigated the induction of autism-like behaviors in mice offspring through exposure to gaseous pollutants and individual VPA. Prenatal exposure to a high concentration of mixed gases (average concentrations of CO, NO 2 , SO 2 , and O 3 were 13.5 ± 2.5, 0.341 ± 0.100, 0.275 ± 0.07, and 0.135 ± 0.010 ppm, respectively) has shown potential to cause autism-like symptoms in offspring. , However, it remains unclear whether a single gas pollutant is capable of inducing similar symptoms. Based on our results focusing on O 3 exposure alone, it can be inferred that O 3 at this dosage did not lead to adverse consequences comparable with VPA in mice.…”

Section: Discussionmentioning

confidence: 99%

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Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model

Ling,

Ren,

Wang

et al. 2023

Environ. Sci. Technol.

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Although there is evidence that exposure to groundlevel ozone (O 3 ) may cause an increased risk of neurological disorders (e.g., autistic spectrum disorder), low-dose chronic ozone exposure and its adverse effects on the nervous system have not been fully understood. Here, we evaluated the potential neurotoxic effects of long-term exposure to environmentally relevant O 3 concentration (200 μg/m 3 via a whole-body inhalation system, 12 h/day for 5 days/week) using a susceptible mouse model of autism induced by valproic acid. Various indicators of oxidative stress, mitochondria, and synapse in the brain tissues were then measured to determine the overall damage of O 3 to the mouse brain. The results showed an aggravated risk of autism in mice offspring, which was embodied in decreased antioxidant contents, disturbed energy generation in mitochondria, as well as reduced expressions of protein kinase Mζ (PKMζ) and synaptic proteins [e.g., Synapsin 1 (SYN 1), postsynaptic density protein-95 (PSD-95)]. Overall, our study indicates that prenatal exposure to environmentally relevant O 3 may exacerbate the symptoms of autism, shedding light on possible molecular mechanisms and providing valuable insights into the pathogenesis of autism, especially concerning low-dose levels of those pollutants.

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Section: Aggravated Phenotypes In a Mouse Model Of Autism Under Chron...supporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model

Ling,

Ren,

Wang

et al. 2023

Environ. Sci. Technol.

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show abstract

“…Beta-carotene has been proved could rescue autistic-like social behavior in BALB/c and BTBR mice through enhancing brain oxytocin, oxytocin receptor gene expression and serum oxytocin levels (Bales et al, 2014;Avraham et al, 2019Avraham et al, , 2021. Decreased oxytocin receptor (OXTR) and serum oxytocin levels were also reported in valproic acid (VPA) induced ASD models, and administration of oxytocin improved social behavior in these induced anminals (Hidema et al, 2020;Tsuji et al, 2021;Imam et al, 2022).…”

Section: Neural Activity Changes In Autism Spectrum Disorder Brain Re...mentioning

confidence: 99%

Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior

Zhang

Wang

et al. 2022

Front. Neurosci.

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Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance.

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Neurodevelopmental consequences of gestational exposure to particulate matter 10: Ultrasonic vocalizations and gene expression analysis using a bayesian approach

Ruiz-Sobremazas,

Ruiz Coca,

Morales-Navas

et al. 2024

Environmental Research

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RETRACTED ARTICLE: Autism-like symptoms by exposure to air pollution and valproic acid–induced in male rats

Cited by 3 publications

References 107 publications

Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model

Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model

Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior

Neurodevelopmental consequences of gestational exposure to particulate matter 10: Ultrasonic vocalizations and gene expression analysis using a bayesian approach

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